Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell
Electrophysiological, clinical and histological techniques were used to monitor the time course of events related to experimental allergic neuritis (EAN) in 48 Lewis rats. The primary lesion was found to be paranodal demyelination without cellular infiltration. Endoneural phagocytes derive from hema...
Gespeichert in:
| Veröffentlicht in: | Acta neuropathologica 1989-01, Vol.77 (4), p.412-419 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 419 |
|---|---|
| container_issue | 4 |
| container_start_page | 412 |
| container_title | Acta neuropathologica |
| container_volume | 77 |
| creator | Stevens, A Schabet, M Schott, K Wiethölter, H |
| description | Electrophysiological, clinical and histological techniques were used to monitor the time course of events related to experimental allergic neuritis (EAN) in 48 Lewis rats. The primary lesion was found to be paranodal demyelination without cellular infiltration. Endoneural phagocytes derive from hematogenous ED1+ED2- monocytes and possibly from resident ED1-ED2+ monocytic cells, not from Schwann cells and fibroblasts. We demonstrate a population of monocytic Ia-bearing, ED1-ED2+ spindle-shaped cells residing in normal peripheral nerve and provide evidence for their transformation into macrophages in the course of EAN. |
| doi_str_mv | 10.1007/BF00687376 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78953944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78953944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c313t-4e56aa139270d852dcb66629c6b9ca8bdc545592b6e466ee52dc06af8a3e67343</originalsourceid><addsrcrecordid>eNqFkc1LxDAQxYMo67p68S7k5EGo5qNJ2qMurgoLgui5pOl0N9I2NWnB_e9N2UWPnoYZfu8xvIfQJSW3lBB197AiRGaKK3mE5jTlLCGC82M0J4TQRHLGTtFZCJ9xYyoVMzRjKhOcyTlq31wD2NUYusp1MHrdYANNE7DtMHz34G0L3RCvumnAb6zBE2UHG7DuKmy22mszRCzowbpustLYQ7BVlOF-qzfO7IYom1zP0UmtmwAXh7lAH6vH9-Vzsn59elnerxPDKR-SFITUmvKcKVJlglWmlFKy3MgyNzorKyNSIXJWSkilBJgIInWdaQ5S8ZQv0PXet_fua4QwFK0N0wO6AzeGQmW54Hn6P0gFJzmPaS7QzR403oXgoS76mIz2u4KSYiqh-CshwlcH17FsofpFD6nzHwIygo8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15309305</pqid></control><display><type>article</type><title>Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Stevens, A ; Schabet, M ; Schott, K ; Wiethölter, H</creator><creatorcontrib>Stevens, A ; Schabet, M ; Schott, K ; Wiethölter, H</creatorcontrib><description>Electrophysiological, clinical and histological techniques were used to monitor the time course of events related to experimental allergic neuritis (EAN) in 48 Lewis rats. The primary lesion was found to be paranodal demyelination without cellular infiltration. Endoneural phagocytes derive from hematogenous ED1+ED2- monocytes and possibly from resident ED1-ED2+ monocytic cells, not from Schwann cells and fibroblasts. We demonstrate a population of monocytic Ia-bearing, ED1-ED2+ spindle-shaped cells residing in normal peripheral nerve and provide evidence for their transformation into macrophages in the course of EAN.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/BF00687376</identifier><identifier>PMID: 2785326</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Electrophysiology ; Female ; Immunohistochemistry ; Neuritis, Autoimmune, Experimental - pathology ; Neuritis, Autoimmune, Experimental - physiopathology ; Neurons - physiology ; Phagocytes - pathology ; Phagocytes - physiology ; Rats ; Rats, Inbred Lew ; Sciatic Nerve - pathology ; Sciatic Nerve - physiopathology</subject><ispartof>Acta neuropathologica, 1989-01, Vol.77 (4), p.412-419</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-4e56aa139270d852dcb66629c6b9ca8bdc545592b6e466ee52dc06af8a3e67343</citedby><cites>FETCH-LOGICAL-c313t-4e56aa139270d852dcb66629c6b9ca8bdc545592b6e466ee52dc06af8a3e67343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2785326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stevens, A</creatorcontrib><creatorcontrib>Schabet, M</creatorcontrib><creatorcontrib>Schott, K</creatorcontrib><creatorcontrib>Wiethölter, H</creatorcontrib><title>Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>Electrophysiological, clinical and histological techniques were used to monitor the time course of events related to experimental allergic neuritis (EAN) in 48 Lewis rats. The primary lesion was found to be paranodal demyelination without cellular infiltration. Endoneural phagocytes derive from hematogenous ED1+ED2- monocytes and possibly from resident ED1-ED2+ monocytic cells, not from Schwann cells and fibroblasts. We demonstrate a population of monocytic Ia-bearing, ED1-ED2+ spindle-shaped cells residing in normal peripheral nerve and provide evidence for their transformation into macrophages in the course of EAN.</description><subject>Animals</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Immunohistochemistry</subject><subject>Neuritis, Autoimmune, Experimental - pathology</subject><subject>Neuritis, Autoimmune, Experimental - physiopathology</subject><subject>Neurons - physiology</subject><subject>Phagocytes - pathology</subject><subject>Phagocytes - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Sciatic Nerve - pathology</subject><subject>Sciatic Nerve - physiopathology</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LxDAQxYMo67p68S7k5EGo5qNJ2qMurgoLgui5pOl0N9I2NWnB_e9N2UWPnoYZfu8xvIfQJSW3lBB197AiRGaKK3mE5jTlLCGC82M0J4TQRHLGTtFZCJ9xYyoVMzRjKhOcyTlq31wD2NUYusp1MHrdYANNE7DtMHz34G0L3RCvumnAb6zBE2UHG7DuKmy22mszRCzowbpustLYQ7BVlOF-qzfO7IYom1zP0UmtmwAXh7lAH6vH9-Vzsn59elnerxPDKR-SFITUmvKcKVJlglWmlFKy3MgyNzorKyNSIXJWSkilBJgIInWdaQ5S8ZQv0PXet_fua4QwFK0N0wO6AzeGQmW54Hn6P0gFJzmPaS7QzR403oXgoS76mIz2u4KSYiqh-CshwlcH17FsofpFD6nzHwIygo8</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Stevens, A</creator><creator>Schabet, M</creator><creator>Schott, K</creator><creator>Wiethölter, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell</title><author>Stevens, A ; Schabet, M ; Schott, K ; Wiethölter, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-4e56aa139270d852dcb66629c6b9ca8bdc545592b6e466ee52dc06af8a3e67343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Immunohistochemistry</topic><topic>Neuritis, Autoimmune, Experimental - pathology</topic><topic>Neuritis, Autoimmune, Experimental - physiopathology</topic><topic>Neurons - physiology</topic><topic>Phagocytes - pathology</topic><topic>Phagocytes - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Sciatic Nerve - pathology</topic><topic>Sciatic Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stevens, A</creatorcontrib><creatorcontrib>Schabet, M</creatorcontrib><creatorcontrib>Schott, K</creatorcontrib><creatorcontrib>Wiethölter, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stevens, A</au><au>Schabet, M</au><au>Schott, K</au><au>Wiethölter, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>77</volume><issue>4</issue><spage>412</spage><epage>419</epage><pages>412-419</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><abstract>Electrophysiological, clinical and histological techniques were used to monitor the time course of events related to experimental allergic neuritis (EAN) in 48 Lewis rats. The primary lesion was found to be paranodal demyelination without cellular infiltration. Endoneural phagocytes derive from hematogenous ED1+ED2- monocytes and possibly from resident ED1-ED2+ monocytic cells, not from Schwann cells and fibroblasts. We demonstrate a population of monocytic Ia-bearing, ED1-ED2+ spindle-shaped cells residing in normal peripheral nerve and provide evidence for their transformation into macrophages in the course of EAN.</abstract><cop>Germany</cop><pmid>2785326</pmid><doi>10.1007/BF00687376</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6322 |
| ispartof | Acta neuropathologica, 1989-01, Vol.77 (4), p.412-419 |
| issn | 0001-6322 1432-0533 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78953944 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Electrophysiology Female Immunohistochemistry Neuritis, Autoimmune, Experimental - pathology Neuritis, Autoimmune, Experimental - physiopathology Neurons - physiology Phagocytes - pathology Phagocytes - physiology Rats Rats, Inbred Lew Sciatic Nerve - pathology Sciatic Nerve - physiopathology |
| title | Role of endoneural cells in experimental allergic neuritis and characterisation of a resident phagocytic cell |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T18%3A45%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20endoneural%20cells%20in%20experimental%20allergic%20neuritis%20and%20characterisation%20of%20a%20resident%20phagocytic%20cell&rft.jtitle=Acta%20neuropathologica&rft.au=Stevens,%20A&rft.date=1989-01-01&rft.volume=77&rft.issue=4&rft.spage=412&rft.epage=419&rft.pages=412-419&rft.issn=0001-6322&rft.eissn=1432-0533&rft_id=info:doi/10.1007/BF00687376&rft_dat=%3Cproquest_cross%3E78953944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15309305&rft_id=info:pmid/2785326&rfr_iscdi=true |