Antitumor Imide Derivatives of 7-Oxabicyclo[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic Acid
The imide and methylimide derivatives of 7-oxobicyclo-[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic acid were synthesized and shown to have antitumor inhibitory activity (growth inhibition) against the KB cell line. The compounds were prepared according to standard procedures. Interest in the respect...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1989-01, Vol.78 (1), p.66-67 |
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| container_end_page | 67 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 78 |
| creator | Walter, Wilbert G. |
| description | The imide and methylimide derivatives of 7-oxobicyclo-[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic acid were synthesized and shown to have antitumor inhibitory activity (growth inhibition) against the KB cell line. The compounds were prepared according to standard procedures. Interest in the respective imide derivatives stemmed from their structural relationship to antitumor-active derivatives of 7-oxobicyclo[2.2.1]heptane-2,3-dicarboxylic acid which lacked 2,3-dimethyl substituents or which were derivatives of isoindolines and lacked the carbonyl groups. |
| doi_str_mv | 10.1002/jps.2600780117 |
| format | Article |
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The compounds were prepared according to standard procedures. Interest in the respective imide derivatives stemmed from their structural relationship to antitumor-active derivatives of 7-oxobicyclo[2.2.1]heptane-2,3-dicarboxylic acid which lacked 2,3-dimethyl substituents or which were derivatives of isoindolines and lacked the carbonyl groups.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600780117</identifier><identifier>PMID: 2709322</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Biological and medical sciences ; Cantharidin - analogs & derivatives ; Cantharidin - analysis ; Cantharidin - chemical synthesis ; Cantharidin - pharmacology ; Cell Line ; General aspects ; Humans ; Imides ; Isoindoles ; KB Cells ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of pharmaceutical sciences, 1989-01, Vol.78 (1), p.66-67</ispartof><rights>1989 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1988 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4567-b2e370dac35988c77029d7def2aee7bcb7782602fa0a9780f0bfa698ff97b5c13</citedby><cites>FETCH-LOGICAL-c4567-b2e370dac35988c77029d7def2aee7bcb7782602fa0a9780f0bfa698ff97b5c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600780117$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600780117$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7292352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2709322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walter, Wilbert G.</creatorcontrib><title>Antitumor Imide Derivatives of 7-Oxabicyclo[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic Acid</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The imide and methylimide derivatives of 7-oxobicyclo-[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic acid were synthesized and shown to have antitumor inhibitory activity (growth inhibition) against the KB cell line. The compounds were prepared according to standard procedures. Interest in the respective imide derivatives stemmed from their structural relationship to antitumor-active derivatives of 7-oxobicyclo[2.2.1]heptane-2,3-dicarboxylic acid which lacked 2,3-dimethyl substituents or which were derivatives of isoindolines and lacked the carbonyl groups.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Biological and medical sciences</subject><subject>Cantharidin - analogs & derivatives</subject><subject>Cantharidin - analysis</subject><subject>Cantharidin - chemical synthesis</subject><subject>Cantharidin - pharmacology</subject><subject>Cell Line</subject><subject>General aspects</subject><subject>Humans</subject><subject>Imides</subject><subject>Isoindoles</subject><subject>KB Cells</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAQxS0EKkvLlRtSDogTCf6oM_FxtbRLq0JBgHoAZDnOWHVJNls7u2z-e7JKtIgD6mk0mt-bmfcIecFoxijlb-_WMeM5pVBQxuARmTHJaZpTBo_JbAB4KuSpekqexXhHKc2plEfkiANVgvMZ-TFfdb7bNG1ILhpfYfIOg9-azm8xJq1LIL3emdLb3tbtd57xjP28xXVnVpjyNyKtfIPdbV9PjTWhbHd97W0yt746IU-cqSM-n-ox-XZ-9nXxPr26Xl4s5lepPZU5pCVHAbQyVkhVFBaAclVBhY4bRChtCVAMFrkz1KjBp6OlM7kqnFNQSsvEMXk97l2H9n6DsdONjxbreniz3UQNhZIihz2YjaANbYwBnV4H35jQa0b1Pk49xKn_xjkIXk6bN2WD1QGf8hvmr6a5idbULpiV9fGAAVdcyD2mRuy3r7F_4Ki-_PTlnxfSUetjh7uD1oRfOgcBUt98XGp-82Fxvvx8qfOBL0Yeh8S3HoOO1uPKYuUD2k5Xrf-f2z9sR66B</recordid><startdate>198901</startdate><enddate>198901</enddate><creator>Walter, Wilbert G.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198901</creationdate><title>Antitumor Imide Derivatives of 7-Oxabicyclo[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic Acid</title><author>Walter, Wilbert G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4567-b2e370dac35988c77029d7def2aee7bcb7782602fa0a9780f0bfa698ff97b5c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Biological and medical sciences</topic><topic>Cantharidin - analogs & derivatives</topic><topic>Cantharidin - analysis</topic><topic>Cantharidin - chemical synthesis</topic><topic>Cantharidin - pharmacology</topic><topic>Cell Line</topic><topic>General aspects</topic><topic>Humans</topic><topic>Imides</topic><topic>Isoindoles</topic><topic>KB Cells</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walter, Wilbert G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walter, Wilbert G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor Imide Derivatives of 7-Oxabicyclo[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic Acid</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1989-01</date><risdate>1989</risdate><volume>78</volume><issue>1</issue><spage>66</spage><epage>67</epage><pages>66-67</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>The imide and methylimide derivatives of 7-oxobicyclo-[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic acid were synthesized and shown to have antitumor inhibitory activity (growth inhibition) against the KB cell line. The compounds were prepared according to standard procedures. Interest in the respective imide derivatives stemmed from their structural relationship to antitumor-active derivatives of 7-oxobicyclo[2.2.1]heptane-2,3-dicarboxylic acid which lacked 2,3-dimethyl substituents or which were derivatives of isoindolines and lacked the carbonyl groups.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>2709322</pmid><doi>10.1002/jps.2600780117</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1989-01, Vol.78 (1), p.66-67 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic agents Antineoplastic Agents - chemical synthesis Biological and medical sciences Cantharidin - analogs & derivatives Cantharidin - analysis Cantharidin - chemical synthesis Cantharidin - pharmacology Cell Line General aspects Humans Imides Isoindoles KB Cells Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments |
| title | Antitumor Imide Derivatives of 7-Oxabicyclo[2.2.1]heptane-2,3-dimethyl-2,3-dicarboxylic Acid |
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