Improvements in automated PNA synthesis using Boc/Z monomers

An optimized automated PNA synthesis protocol is reported. Under optimal conditions the product yield of a test 17‐mer PNA is approximately 90%. The average coupling yield is 99.4%. The synthesis strategy is Boc/Z and the deprotected amine is neutralized in situ. The monomers are added in molar exce...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The journal of peptide research 1997-01, Vol.49 (1), p.80-88
Hauptverfasser:	KOCH, TROELS, HANSEN, HENRIK F., ANDERSEN, PETER, LARSEN, TINNA, BATZ, HANS G., OTTESON, KENNETH, ØRUM, HENRIK
Format:	Artikel
Sprache:	eng
Schlagworte:	5 μmol synthesis scale Biopolymers Boc Z-synthesis strategy Chromatography, High Pressure Liquid Glycine - analogs & derivatives Glycine - chemistry heteroselective solvation Nucleic Acids - chemical synthesis optimized protocol Peptides - chemical synthesis Piperidines - chemistry Purines - chemistry Pyrimidinones - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!