Reduction potentials of anthelmintic drugs: Possible relationship to activity
Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminuquinones, and nitroheterocytes. Reductions usually were in the favorable range of +0.2 to −0.7 V versus normal hydrogen electrode. The drug...
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| Veröffentlicht in: | Free radical biology & medicine 1989, Vol.6 (2), p.131-139 |
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| container_end_page | 139 |
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| container_title | Free radical biology & medicine |
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| creator | Kovacic, Peter Ames, James R. Rector, Douglas L. Jawdosiuk, Mikolaj Ryan, Michael D. |
| description | Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminuquinones, and nitroheterocytes. Reductions usually were in the favorable range of +0.2 to −0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed. |
| doi_str_mv | 10.1016/0891-5849(89)90110-X |
| format | Article |
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Reductions usually were in the favorable range of +0.2 to −0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/0891-5849(89)90110-X</identifier><identifier>PMID: 2707616</identifier><identifier>CODEN: FRBMEH</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anthelmintic action ; Anthelmintics - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimony ; Antiparasitic agents ; Arsenic - pharmacology ; Benzimidazoles - pharmacology ; Biguanides - pharmacology ; Biological and medical sciences ; Carbon Tetrachloride - pharmacology ; Chemical Phenomena ; Chemistry ; Coloring Agents - pharmacology ; Electrochemistry ; Helminths - drug effects ; Hydrazones - pharmacology ; Iminium ions ; Medical sciences ; Metal derivatives and chelators ; Nitro Compounds - pharmacology ; Nitroheterocycles ; Oxidation-Reduction ; Peroxides - pharmacology ; Pharmacology. Drug treatments ; Phenothiazines - pharmacology ; Pyridines - pharmacology ; Quinones ; Quinones - pharmacology ; Structure-Activity Relationship</subject><ispartof>Free radical biology & medicine, 1989, Vol.6 (2), p.131-139</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-fc7924ae2536645a5f6dbbebff0ae8998d5b71a23afdb3657451af0e8ae4678d3</citedby><cites>FETCH-LOGICAL-c387t-fc7924ae2536645a5f6dbbebff0ae8998d5b71a23afdb3657451af0e8ae4678d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/089158498990110X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19553638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2707616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kovacic, Peter</creatorcontrib><creatorcontrib>Ames, James R.</creatorcontrib><creatorcontrib>Rector, Douglas L.</creatorcontrib><creatorcontrib>Jawdosiuk, Mikolaj</creatorcontrib><creatorcontrib>Ryan, Michael D.</creatorcontrib><title>Reduction potentials of anthelmintic drugs: Possible relationship to activity</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminuquinones, and nitroheterocytes. Reductions usually were in the favorable range of +0.2 to −0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed.</description><subject>Animals</subject><subject>Anthelmintic action</subject><subject>Anthelmintics - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimony</subject><subject>Antiparasitic agents</subject><subject>Arsenic - pharmacology</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biguanides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbon Tetrachloride - pharmacology</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Coloring Agents - pharmacology</subject><subject>Electrochemistry</subject><subject>Helminths - drug effects</subject><subject>Hydrazones - pharmacology</subject><subject>Iminium ions</subject><subject>Medical sciences</subject><subject>Metal derivatives and chelators</subject><subject>Nitro Compounds - pharmacology</subject><subject>Nitroheterocycles</subject><subject>Oxidation-Reduction</subject><subject>Peroxides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenothiazines - pharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Quinones</subject><subject>Quinones - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LHDEUhkOp6Gr7D1qYG0UvxiYz-fRCEPELViylBe9CJjnRyOzMmmSE_ffNdhe961Ug53lfznkQ-kbwKcGE_8BSkZpJqo6lOlGYEFw_fkIzIkVbU6b4ZzR7R_bQfkovGGPKWrmLdhuBBSd8hu5_gZtsDuNQLccMQw6mT9XoKzPkZ-gXofzYysXpKZ1VP8eUQtdDFaE360x6Dssqj5UpDW8hr76gHV_y8HX7HqA_11e_L2_r-cPN3eXFvLatFLn2VqiGGmhYyzllhnnuug4677EBqZR0rBPENK3xrms5E5QR4zFIA5QL6doDdLTpXcbxdYKU9SIkC31vBhinpIVUrMG0KSDdgDaW3SN4vYxhYeJKE6zXFvVakV4r0lLpfxb1Y4l93_ZP3QLce2irrcwPt3OTrOl9NIMN6aNbsXJZKwt3vuGgyHgLEHWyAQYLLkSwWbsx_H-Rv3k2kBQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Kovacic, Peter</creator><creator>Ames, James R.</creator><creator>Rector, Douglas L.</creator><creator>Jawdosiuk, Mikolaj</creator><creator>Ryan, Michael D.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Reduction potentials of anthelmintic drugs: Possible relationship to activity</title><author>Kovacic, Peter ; Ames, James R. ; Rector, Douglas L. ; Jawdosiuk, Mikolaj ; Ryan, Michael D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-fc7924ae2536645a5f6dbbebff0ae8998d5b71a23afdb3657451af0e8ae4678d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Anthelmintic action</topic><topic>Anthelmintics - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimony</topic><topic>Antiparasitic agents</topic><topic>Arsenic - pharmacology</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biguanides - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbon Tetrachloride - pharmacology</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Coloring Agents - pharmacology</topic><topic>Electrochemistry</topic><topic>Helminths - drug effects</topic><topic>Hydrazones - pharmacology</topic><topic>Iminium ions</topic><topic>Medical sciences</topic><topic>Metal derivatives and chelators</topic><topic>Nitro Compounds - pharmacology</topic><topic>Nitroheterocycles</topic><topic>Oxidation-Reduction</topic><topic>Peroxides - pharmacology</topic><topic>Pharmacology. 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| identifier | ISSN: 0891-5849 |
| ispartof | Free radical biology & medicine, 1989, Vol.6 (2), p.131-139 |
| issn | 0891-5849 1873-4596 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anthelmintic action Anthelmintics - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimony Antiparasitic agents Arsenic - pharmacology Benzimidazoles - pharmacology Biguanides - pharmacology Biological and medical sciences Carbon Tetrachloride - pharmacology Chemical Phenomena Chemistry Coloring Agents - pharmacology Electrochemistry Helminths - drug effects Hydrazones - pharmacology Iminium ions Medical sciences Metal derivatives and chelators Nitro Compounds - pharmacology Nitroheterocycles Oxidation-Reduction Peroxides - pharmacology Pharmacology. Drug treatments Phenothiazines - pharmacology Pyridines - pharmacology Quinones Quinones - pharmacology Structure-Activity Relationship |
| title | Reduction potentials of anthelmintic drugs: Possible relationship to activity |
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