A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant

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Veröffentlicht in:	Journal of medicinal chemistry 1989-05, Vol.32 (5), p.937-940
Hauptverfasser:	Inglese, James, Blatchly, Richard A, Benkovic, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - antagonists & inhibitors Antineoplastic Agents - pharmacology Chemistry Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Hydroxymethyl and Formyl Transferases Molecular Conformation Organic chemistry Phosphoribosylglycinamide Formyltransferase Preparations and properties Purines - biosynthesis Ribonucleotides - chemical synthesis Ribonucleotides - metabolism Ribonucleotides - pharmacology
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