Platinum concentrations and DNA adduct levels in tumors and organs of cisplatin-treated LOU/M rats inoculated with cisplatin-sensitive or -resistant immunoglobulin M immunocytoma

Female LOU/M rats, bearing either a cisplatin (cisDDP)-sensitive or -resistant IgM immunocytoma, were sacrificed at 1 or 24 h after cisDDP administration (i.v., 10 mg/kg of body weight). Platinum levels, determined with atomic absorption spectroscopy, were in the order kidney much greater than liver...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-06, Vol.49 (11), p.2862-2867
Hauptverfasser:	FICHTINGER-SCHEPMAN, A. M. J, VENDRIK, C. P. J, SCHORNAGEL, J. H, BERENDS, F, VAN DIJK-KNIJNENBURG, W. C. M, DE JONG, W. H, VAN DER MINNEN, A. C. E, CLAESSEN, A. M. E, VAN DER VELDE-VISSER, S. D, DE GROOT, G, WUBS, K. L, STEERENBERG, P. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cisplatin - pharmacokinetics DNA, Neoplasm - metabolism Female General aspects Kidney - metabolism Liver - metabolism Medical sciences Pharmacology. Drug treatments Platinum - pharmacokinetics Rats Spleen - metabolism Time Factors Tissue Distribution
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