Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals

In this paper we describe the effect of activated protein C (APC) on thrombin generation initiated in platelet-poor plasma via the extrinsic or the intrinsic pathway. Thrombin was determined with a specific chromogenic substrate and quantitated by calculating the time integral of the thrombin genera...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 1997-01, Vol.8 (1), p.28-38
Hauptverfasser:	Nicolaes, G A. F, Thomassen, M C. L. G. D, Tans, G, Rosing, J, Hemker, H C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug Resistance - genetics Female Hematologic and hematopoietic diseases Hematology Heterozygote Homozygote Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet diseases and coagulopathies Pregnancy Protein C - pharmacology Thrombin - biosynthesis Thrombin - genetics Thrombin Time
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