Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism

We investigated the effect of in , vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-03, Vol.159 (2), p.755-762
Hauptverfasser:	DeCherney, G.Stephen, Gesundheit, Neil, Gyves, Peter W., Showalter, Claudia R., Weintraub, Bruce D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological and medical sciences Carbohydrate Conformation Cell physiology Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Hormonal regulation Hypothyroidism - metabolism Hypothyroidism - physiopathology Male Mice Mice, Inbred Strains Molecular and cellular biology Oligosaccharides - metabolism Sialic Acids - metabolism Sulfates - metabolism thyroid thyrotropin Thyrotropin - metabolism
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