Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism
We investigated the effect of in , vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1989-03, Vol.159 (2), p.755-762 |
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| container_title | Biochemical and biophysical research communications |
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| creator | DeCherney, G.Stephen Gesundheit, Neil Gyves, Peter W. Showalter, Claudia R. Weintraub, Bruce D. |
| description | We investigated the effect of
in
,
vivo
hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both α and β subunits. Aging
per
,
se
had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously. |
| doi_str_mv | 10.1016/0006-291X(89)90059-4 |
| format | Article |
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in
,
vivo
hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both α and β subunits. Aging
per
,
se
had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(89)90059-4</identifier><identifier>PMID: 2930540</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Aging ; Animals ; Biological and medical sciences ; Carbohydrate Conformation ; Cell physiology ; Chromatography, High Pressure Liquid ; Fundamental and applied biological sciences. Psychology ; Hormonal regulation ; Hypothyroidism - metabolism ; Hypothyroidism - physiopathology ; Male ; Mice ; Mice, Inbred Strains ; Molecular and cellular biology ; Oligosaccharides - metabolism ; Sialic Acids - metabolism ; Sulfates - metabolism ; thyroid ; thyrotropin ; Thyrotropin - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1989-03, Vol.159 (2), p.755-762</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-4ee3b61e93c9f66d7b5c29983ff10e12cbd6fe5913d49c2c069386fc70a522793</citedby><cites>FETCH-LOGICAL-c483t-4ee3b61e93c9f66d7b5c29983ff10e12cbd6fe5913d49c2c069386fc70a522793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(89)90059-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6820099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2930540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeCherney, G.Stephen</creatorcontrib><creatorcontrib>Gesundheit, Neil</creatorcontrib><creatorcontrib>Gyves, Peter W.</creatorcontrib><creatorcontrib>Showalter, Claudia R.</creatorcontrib><creatorcontrib>Weintraub, Bruce D.</creatorcontrib><title>Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>We investigated the effect of
in
,
vivo
hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both α and β subunits. Aging
per
,
se
had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously.</description><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Conformation</subject><subject>Cell physiology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormonal regulation</subject><subject>Hypothyroidism - metabolism</subject><subject>Hypothyroidism - physiopathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Molecular and cellular biology</subject><subject>Oligosaccharides - metabolism</subject><subject>Sialic Acids - metabolism</subject><subject>Sulfates - metabolism</subject><subject>thyroid</subject><subject>thyrotropin</subject><subject>Thyrotropin - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGLFDEQhYO4rOPqP1Dog4geWivpJNN1WVgWdRcWvCh4C5mkwka6O2PSszD_3sxMM0eFQEje94qqV4y94fCJA9efAUC3AvmvDz1-RACFrXzGVhwQWsFBPmerM_KCvSzlNwDnUuMluxTYgZKwYv5mmCnbOaapNHFq5kdqSrTDfjj-NXbyTdkN4fRKoSnkMs3kmzHtClV-n9Oc07Z669nmONq8bx7323SUoo9lfMUugh0KvV7uK_bz65cft3ftw_dv97c3D62TfTe3kqjbaE7YOQxa-_VGOYHYdyFwIC7cxutACnnnJTrhQGPX6-DWYJUQa-yu2PtT3W1Of3ZUZjPG4mgY7ES1W7PuUVaL-i_IlVAcVV9BeQJdTqVkCmaZ0HAwhy2YQ8TmELHp0Ry3YGS1vV3q7zYj-bNpib3q7xbdFmeHkO3kYjljuhcAeJjn-oRRDe0pUjbFRZoc-ZjJzcan-O8-_gJHnaVK</recordid><startdate>19890315</startdate><enddate>19890315</enddate><creator>DeCherney, G.Stephen</creator><creator>Gesundheit, Neil</creator><creator>Gyves, Peter W.</creator><creator>Showalter, Claudia R.</creator><creator>Weintraub, Bruce D.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19890315</creationdate><title>Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism</title><author>DeCherney, G.Stephen ; Gesundheit, Neil ; Gyves, Peter W. ; Showalter, Claudia R. ; Weintraub, Bruce D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-4ee3b61e93c9f66d7b5c29983ff10e12cbd6fe5913d49c2c069386fc70a522793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Conformation</topic><topic>Cell physiology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fundamental and applied biological sciences. 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in
,
vivo
hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both α and β subunits. Aging
per
,
se
had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2930540</pmid><doi>10.1016/0006-291X(89)90059-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 1989-03, Vol.159 (2), p.755-762 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aging Animals Biological and medical sciences Carbohydrate Conformation Cell physiology Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Hormonal regulation Hypothyroidism - metabolism Hypothyroidism - physiopathology Male Mice Mice, Inbred Strains Molecular and cellular biology Oligosaccharides - metabolism Sialic Acids - metabolism Sulfates - metabolism thyroid thyrotropin Thyrotropin - metabolism |
| title | Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism |
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