Wortmannin blocks goldfish retinal phosphatidylinositol 3-kinase and neurite outgrowth

The goldfish retina has been used extensively for the study of nerve regeneration. A role for phosphatidylinositol 3-kinase (PI3K) in neurite outgrowth from goldfish retinal explants has been examined by means of wortmannin (WT), a selective inhibitor of the enzyme. The presence of PI3K in retinal e...

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Veröffentlicht in:	Neurochemical research 1997-04, Vol.22 (4), p.373-378
Hauptverfasser:	LAVIE, Y, DYBOWSKI, J, AGRANOFF, B. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Biological and medical sciences Blotting, Western Carassius auratus Enzyme Inhibitors - pharmacology Eye and associated structures. Visual pathways and centers. Vision Freshwater Fundamental and applied biological sciences. Psychology Goldfish Immunosorbent Techniques Nerve Regeneration Neurites - drug effects Neurites - physiology Neurons Optic Nerve - physiology Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Proteins Retina - drug effects Retina - enzymology Retina - ultrastructure Vertebrates: nervous system and sense organs Wortmannin
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