Warfarin Resistance and Enteral Feedings
Nutritional support via enteral feeding tubes may interfere with the response to medications by a number of mechanisms. A 31-year-old, white man was admitted after sustaining a gunshot wound to the chest and mandible. Subsequently, the patient developed pulmonary emboli documented by angiography. At...
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| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 1989-03, Vol.13 (2), p.206-208 |
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| container_title | JPEN. Journal of parenteral and enteral nutrition |
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| creator | Martin, Jill E. Lutomski, Dave M. |
| description | Nutritional support via enteral feeding tubes may interfere with the response to medications by a number of mechanisms. A 31-year-old, white man was admitted after sustaining a gunshot wound to the chest and mandible. Subsequently, the patient developed pulmonary emboli documented by angiography. Attempts at anticoagulation with oral warfarin were unsuccessful while the patient was receiving 50-100 ml/ hr of Osmolite through an Entriflex feeding tube and intermittent oral Ensure Plus supplements. Discontinuation of the Osmolite resulted in a prompt prolongation of the prothrombin time. The Ensure Plus was continued and adequate prothrombin times were achieved on 7.5 to 10 mg of warfarin daily. The total amount of vitamin K received from the enteral feedings ranged from 50 to 115 μg/day, which is less than the normal daily intake of 300 to 500 μg. Previous reports of warfarin resistance implicated older enteral feeding products with a much higher vitamin K content. Difficulty with anticoagulation may still be experienced with the newer formulations. It is unknown whether the vitamin K content or malabsorption of warfarin is the mechanism of resistance. (Journal of Parenteral and Enteral Nutrition
13:206-208, 1989) |
| doi_str_mv | 10.1177/0148607189013002206 |
| format | Article |
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13:206-208, 1989)</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Drug Administration Routes</subject><subject>Drug Resistance</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Enteral Nutrition - adverse effects</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prothrombin Time</subject><subject>Pulmonary Embolism - drug therapy</subject><subject>Vitamin K - administration & dosage</subject><subject>Warfarin - administration & dosage</subject><subject>Warfarin - pharmacology</subject><subject>Wounds, Gunshot - therapy</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1Lw0AQhhdRaq3-AhFyEPESnc1uspujlNYPiooUPC67m0lJSdO62yD9925N8CTiaQ7zvO8MDyHnFG4oFeIWKJcZCCpzoAwgSSA7IEOacxonnPNDMtwT8R45JifeLwGAZQADMkh4niUpHZLrd-1K7aomekNf-a1uLEa6KaJJs0Wn62iKWFTNwp-So1LXHs_6OSLz6WQ-fohnL_eP47tZbHm4H1OGRSFlyqCwJdMiNzzRmSxSCyXPkGqN3DBqcuAmUMIUlhkrmUmZDFk2Ildd7catP1r0W7WqvMW61g2uW6-EzLlknAeQdaB1a-8dlmrjqpV2O0VB7fWoX_SE1EVf35oVFj-Z3kfYX_Z77a2uSxd8VP4HEzQV2XdN3mGfVY27_1xWT6-TZ-hegC7r9QLVct26Jvj88-svEZWH-Q</recordid><startdate>198903</startdate><enddate>198903</enddate><creator>Martin, Jill E.</creator><creator>Lutomski, Dave M.</creator><general>Sage Publications</general><general>SAGE Publications</general><general>ASPEN</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198903</creationdate><title>Warfarin Resistance and Enteral Feedings</title><author>Martin, Jill E. ; Lutomski, Dave M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4206-13edd88530dcf3a79b42a68d5c0f46e1aae4b31b904b8537bdc3bc83b53813e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Drug Administration Routes</topic><topic>Drug Resistance</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Enteral Nutrition - adverse effects</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prothrombin Time</topic><topic>Pulmonary Embolism - drug therapy</topic><topic>Vitamin K - administration & dosage</topic><topic>Warfarin - administration & dosage</topic><topic>Warfarin - pharmacology</topic><topic>Wounds, Gunshot - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Jill E.</creatorcontrib><creatorcontrib>Lutomski, Dave M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Jill E.</au><au>Lutomski, Dave M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Warfarin Resistance and Enteral Feedings</atitle><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle><addtitle>JPEN J Parenter Enteral Nutr</addtitle><date>1989-03</date><risdate>1989</risdate><volume>13</volume><issue>2</issue><spage>206</spage><epage>208</epage><pages>206-208</pages><issn>0148-6071</issn><eissn>1941-2444</eissn><coden>JPENDU</coden><abstract>Nutritional support via enteral feeding tubes may interfere with the response to medications by a number of mechanisms. A 31-year-old, white man was admitted after sustaining a gunshot wound to the chest and mandible. Subsequently, the patient developed pulmonary emboli documented by angiography. Attempts at anticoagulation with oral warfarin were unsuccessful while the patient was receiving 50-100 ml/ hr of Osmolite through an Entriflex feeding tube and intermittent oral Ensure Plus supplements. Discontinuation of the Osmolite resulted in a prompt prolongation of the prothrombin time. The Ensure Plus was continued and adequate prothrombin times were achieved on 7.5 to 10 mg of warfarin daily. The total amount of vitamin K received from the enteral feedings ranged from 50 to 115 μg/day, which is less than the normal daily intake of 300 to 500 μg. Previous reports of warfarin resistance implicated older enteral feeding products with a much higher vitamin K content. Difficulty with anticoagulation may still be experienced with the newer formulations. It is unknown whether the vitamin K content or malabsorption of warfarin is the mechanism of resistance. (Journal of Parenteral and Enteral Nutrition
13:206-208, 1989)</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>2496251</pmid><doi>10.1177/0148607189013002206</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0148-6071 |
| ispartof | JPEN. Journal of parenteral and enteral nutrition, 1989-03, Vol.13 (2), p.206-208 |
| issn | 0148-6071 1941-2444 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Drug Administration Routes Drug Resistance Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Enteral Nutrition - adverse effects Humans Intensive care medicine Male Medical sciences Prothrombin Time Pulmonary Embolism - drug therapy Vitamin K - administration & dosage Warfarin - administration & dosage Warfarin - pharmacology Wounds, Gunshot - therapy |
| title | Warfarin Resistance and Enteral Feedings |
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