Regulation of ciprofloxacin uptake in human promyelocytic leukemia cells and polymorphonuclear leukocytes

Polymorphonuclear leukocytes (PMNs) actively internalize ciprofloxacin, a capability that can enhance killing of intracellular bacteria and facilitate delivery of the antimicrobial agent to infection sites by migrating PMNs. In this study we investigated mechanisms for upregulation of this process....

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Veröffentlicht in:	Journal of leukocyte biology 1997-05, Vol.61 (5), p.619-623
Hauptverfasser:	Loo, Kwor C., Cario, Anthony C., Zhang, Fanjie, Walters, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - blood Anti-Infective Agents - pharmacokinetics antimicrobial delivery Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cells, Cultured Ciprofloxacin - blood Ciprofloxacin - pharmacokinetics Enzyme Inhibitors - pharmacology Flavonoids - pharmacology fluoroquinolone HL-60 Cells - enzymology HL-60 Cells - metabolism Humans infection mitogen‐activated protein kinase myeloid maturation N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophil Activation - drug effects Neutrophils - enzymology Neutrophils - metabolism protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism
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