Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo
Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the...
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| Veröffentlicht in: | Blood 1997-04, Vol.89 (8), p.2635-2643 |
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| creator | SGADARI, C FARBER, J. M ANGIOLILLO, A. L LIAO, F TERUYA-FELDSTEIN, J BURD, P. R YAO, L GUPTA, G KANEGANE, C TOSATO, G |
| description | Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, murine Mig RNA was found to be expressed at higher levels in regressing Burkitt's lymphoma tumors established in nude mice compared with progressively growing tumors. Daily inoculations of purified recombinant human Mig into Burkitt's tumors growing subcutaneously in nude mice consistently caused tumor necrosis associated with extensive vascular damage. These effects were indistinguishable from those produced by intratumor inoculations of Burkitt's tumors with IP-10. These results support the notion that Mig, like IP-10, has antitumor activity in vivo. |
| doi_str_mv | 10.1182/blood.v89.8.2635 |
| format | Article |
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M ; ANGIOLILLO, A. L ; LIAO, F ; TERUYA-FELDSTEIN, J ; BURD, P. R ; YAO, L ; GUPTA, G ; KANEGANE, C ; TOSATO, G</creator><creatorcontrib>SGADARI, C ; FARBER, J. M ; ANGIOLILLO, A. L ; LIAO, F ; TERUYA-FELDSTEIN, J ; BURD, P. R ; YAO, L ; GUPTA, G ; KANEGANE, C ; TOSATO, G</creatorcontrib><description>Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, murine Mig RNA was found to be expressed at higher levels in regressing Burkitt's lymphoma tumors established in nude mice compared with progressively growing tumors. Daily inoculations of purified recombinant human Mig into Burkitt's tumors growing subcutaneously in nude mice consistently caused tumor necrosis associated with extensive vascular damage. These effects were indistinguishable from those produced by intratumor inoculations of Burkitt's tumors with IP-10. These results support the notion that Mig, like IP-10, has antitumor activity in vivo.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.v89.8.2635</identifier><identifier>PMID: 9108380</identifier><language>eng</language><publisher>Washington, DC: The Americain Society of Hematology</publisher><subject>Animals ; Antineoplastic agents ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Blood Vessels - pathology ; Burkitt Lymphoma - drug therapy ; Burkitt Lymphoma - pathology ; Chemokine CXCL10 ; Chemokine CXCL9 ; Chemokines - biosynthesis ; Chemokines - genetics ; Chemokines - pharmacology ; Chemokines - therapeutic use ; Chemokines, CXC ; CHO Cells ; Cricetinae ; Cricetulus ; Cytokines - biosynthesis ; Cytokines - genetics ; Cytokines - pharmacology ; Drug Screening Assays, Antitumor ; Gene Expression Regulation, Neoplastic ; Humans ; Immunotherapy ; Intercellular Signaling Peptides and Proteins ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Necrosis ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Neoplasm Transplantation ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Recombinant Proteins - pharmacology ; Recombinant Proteins - therapeutic use ; Tumor Cells, Cultured</subject><ispartof>Blood, 1997-04, Vol.89 (8), p.2635-2643</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-669a9a0befc1faf69c10602099495bf6a168544f70707e3c9cac9e6c6d62c2263</citedby><cites>FETCH-LOGICAL-c365t-669a9a0befc1faf69c10602099495bf6a168544f70707e3c9cac9e6c6d62c2263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2638037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9108380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SGADARI, C</creatorcontrib><creatorcontrib>FARBER, J. M</creatorcontrib><creatorcontrib>ANGIOLILLO, A. L</creatorcontrib><creatorcontrib>LIAO, F</creatorcontrib><creatorcontrib>TERUYA-FELDSTEIN, J</creatorcontrib><creatorcontrib>BURD, P. R</creatorcontrib><creatorcontrib>YAO, L</creatorcontrib><creatorcontrib>GUPTA, G</creatorcontrib><creatorcontrib>KANEGANE, C</creatorcontrib><creatorcontrib>TOSATO, G</creatorcontrib><title>Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo</title><title>Blood</title><addtitle>Blood</addtitle><description>Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, murine Mig RNA was found to be expressed at higher levels in regressing Burkitt's lymphoma tumors established in nude mice compared with progressively growing tumors. Daily inoculations of purified recombinant human Mig into Burkitt's tumors growing subcutaneously in nude mice consistently caused tumor necrosis associated with extensive vascular damage. These effects were indistinguishable from those produced by intratumor inoculations of Burkitt's tumors with IP-10. These results support the notion that Mig, like IP-10, has antitumor activity in vivo.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - pathology</subject><subject>Burkitt Lymphoma - drug therapy</subject><subject>Burkitt Lymphoma - pathology</subject><subject>Chemokine CXCL10</subject><subject>Chemokine CXCL9</subject><subject>Chemokines - biosynthesis</subject><subject>Chemokines - genetics</subject><subject>Chemokines - pharmacology</subject><subject>Chemokines - therapeutic use</subject><subject>Chemokines, CXC</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Cytokines - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Necrosis</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Transplantation</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Tumor Cells, Cultured</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EKqWwZ4PkBWLVBDsPx16iipcoYgNsLccZQyCJwU4q9bv4D74Jl0bVLGakOXN15yJ0SklMKU8uy8baKl5xEfM4YWm-h6Y0T3hESEL20ZQQwqJMFPQQHXn_QQjN0iSfoImghKecTNHDY_02x_074NZ29rPuANddNWiocLkOYw_OgLNd9Pszx1_OtrYHj_uhtQ53oJ31tQ8YXtUre4wOjGo8nIx9hl5urp8Xd9Hy6fZ-cbWMdMryPmJMKKFICUZTowwTmhIW_AqRibw0TFHG8ywzBQkFqRZaaQFMs4olOglfztDFVjf4-R7A97KtvYamUR3YwcuCiywtmAgg2YIbn96BkV-ubpVbS0rkJj_5n5985UJyuckvnJyN2kPZQrU7GAML-_Nxr7xWjXGq07XfYUEjQEX6B0j1ei4</recordid><startdate>19970415</startdate><enddate>19970415</enddate><creator>SGADARI, C</creator><creator>FARBER, J. M</creator><creator>ANGIOLILLO, A. L</creator><creator>LIAO, F</creator><creator>TERUYA-FELDSTEIN, J</creator><creator>BURD, P. R</creator><creator>YAO, L</creator><creator>GUPTA, G</creator><creator>KANEGANE, C</creator><creator>TOSATO, G</creator><general>The Americain Society of Hematology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970415</creationdate><title>Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo</title><author>SGADARI, C ; FARBER, J. M ; ANGIOLILLO, A. L ; LIAO, F ; TERUYA-FELDSTEIN, J ; BURD, P. R ; YAO, L ; GUPTA, G ; KANEGANE, C ; TOSATO, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-669a9a0befc1faf69c10602099495bf6a168544f70707e3c9cac9e6c6d62c2263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - pathology</topic><topic>Burkitt Lymphoma - drug therapy</topic><topic>Burkitt Lymphoma - pathology</topic><topic>Chemokine CXCL10</topic><topic>Chemokine CXCL9</topic><topic>Chemokines - biosynthesis</topic><topic>Chemokines - genetics</topic><topic>Chemokines - pharmacology</topic><topic>Chemokines - therapeutic use</topic><topic>Chemokines, CXC</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Cytokines - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Necrosis</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Transplantation</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SGADARI, C</creatorcontrib><creatorcontrib>FARBER, J. M</creatorcontrib><creatorcontrib>ANGIOLILLO, A. L</creatorcontrib><creatorcontrib>LIAO, F</creatorcontrib><creatorcontrib>TERUYA-FELDSTEIN, J</creatorcontrib><creatorcontrib>BURD, P. R</creatorcontrib><creatorcontrib>YAO, L</creatorcontrib><creatorcontrib>GUPTA, G</creatorcontrib><creatorcontrib>KANEGANE, C</creatorcontrib><creatorcontrib>TOSATO, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SGADARI, C</au><au>FARBER, J. M</au><au>ANGIOLILLO, A. L</au><au>LIAO, F</au><au>TERUYA-FELDSTEIN, J</au><au>BURD, P. R</au><au>YAO, L</au><au>GUPTA, G</au><au>KANEGANE, C</au><au>TOSATO, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1997-04-15</date><risdate>1997</risdate><volume>89</volume><issue>8</issue><spage>2635</spage><epage>2643</epage><pages>2635-2643</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, murine Mig RNA was found to be expressed at higher levels in regressing Burkitt's lymphoma tumors established in nude mice compared with progressively growing tumors. Daily inoculations of purified recombinant human Mig into Burkitt's tumors growing subcutaneously in nude mice consistently caused tumor necrosis associated with extensive vascular damage. These effects were indistinguishable from those produced by intratumor inoculations of Burkitt's tumors with IP-10. These results support the notion that Mig, like IP-10, has antitumor activity in vivo.</abstract><cop>Washington, DC</cop><pub>The Americain Society of Hematology</pub><pmid>9108380</pmid><doi>10.1182/blood.v89.8.2635</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Blood Vessels - pathology Burkitt Lymphoma - drug therapy Burkitt Lymphoma - pathology Chemokine CXCL10 Chemokine CXCL9 Chemokines - biosynthesis Chemokines - genetics Chemokines - pharmacology Chemokines - therapeutic use Chemokines, CXC CHO Cells Cricetinae Cricetulus Cytokines - biosynthesis Cytokines - genetics Cytokines - pharmacology Drug Screening Assays, Antitumor Gene Expression Regulation, Neoplastic Humans Immunotherapy Intercellular Signaling Peptides and Proteins Medical sciences Mice Mice, Inbred BALB C Mice, Nude Necrosis Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Transplantation Pharmacology. Drug treatments Polymerase Chain Reaction Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Tumor Cells, Cultured |
| title | Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo |
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