Pathways for the synthesis of sorbitol from 13C-labeled hexoses, pentose, and glycerol in renal papillary tissue

Suspensions of rabbit renal papillary tissue were incubated with D‐[ 6‐13C]glucose, D‐[1‐13C]fructose, D‐[1‐13C] ribose, and [2‐13C]glycerol. The perchloric acid extracts of the above incubations were investigated with 13C NMR spectroscopy. All 13C‐labeled substrates give rise to 13C‐labeled D‐sorbi...

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Veröffentlicht in:Magnetic resonance in medicine 1989-03, Vol.9 (3), p.419-422
Hauptverfasser: Jans, A. W. H., Grunewald, R.-W., Kinne, R. K. H.
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creator Jans, A. W. H.
Grunewald, R.-W.
Kinne, R. K. H.
description Suspensions of rabbit renal papillary tissue were incubated with D‐[ 6‐13C]glucose, D‐[1‐13C]fructose, D‐[1‐13C] ribose, and [2‐13C]glycerol. The perchloric acid extracts of the above incubations were investigated with 13C NMR spectroscopy. All 13C‐labeled substrates give rise to 13C‐labeled D‐sorbitol. D‐[6‐13C]Glucose and D[1‐13C]fructose are converted directly into D‐sorbitol via the aldose reductase and sorbitol dehydrogenase pathway, respectively, whereas D‐[1‐13C] ribose and [2‐13C]glycerol give rise to labeling of the D‐glyceraldehyde pool which on its turn causes a labeling of D‐sorbitol. Label exchanges observed from incubations with glycerol and D‐ribose indicate that the pentose shunt plays a role in this synthesis of D‐sorbitol. © 1989 Academic Press, Inc.
doi_str_mv 10.1002/mrm.1910090315
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W. H.</creatorcontrib><creatorcontrib>Grunewald, R.-W.</creatorcontrib><creatorcontrib>Kinne, R. K. H.</creatorcontrib><title>Pathways for the synthesis of sorbitol from 13C-labeled hexoses, pentose, and glycerol in renal papillary tissue</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Suspensions of rabbit renal papillary tissue were incubated with D‐[ 6‐13C]glucose, D‐[1‐13C]fructose, D‐[1‐13C] ribose, and [2‐13C]glycerol. The perchloric acid extracts of the above incubations were investigated with 13C NMR spectroscopy. All 13C‐labeled substrates give rise to 13C‐labeled D‐sorbitol. D‐[6‐13C]Glucose and D[1‐13C]fructose are converted directly into D‐sorbitol via the aldose reductase and sorbitol dehydrogenase pathway, respectively, whereas D‐[1‐13C] ribose and [2‐13C]glycerol give rise to labeling of the D‐glyceraldehyde pool which on its turn causes a labeling of D‐sorbitol. 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Psychology</subject><subject>Glucose - metabolism</subject><subject>Glycerol - metabolism</subject><subject>In Vitro Techniques</subject><subject>Kidney Medulla - metabolism</subject><subject>L-Iditol 2-Dehydrogenase - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Other biological molecules</subject><subject>Pentose Phosphate Pathway</subject><subject>Rabbits</subject><subject>Ribose - metabolism</subject><subject>Sorbitol - biosynthesis</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1vEzEQxS0EKqFw5YbkA-LULf5cr480ogWRAEKgHi2vPUsM3g_sjdr973GVKD3NjN7vjUbzEHpNySUlhL3vU39JdWk14VQ-QSsqGauY1OIpWhElSMWpFs_Ri5z_kEJpJc7QGRO6Zo1Yoem7nXd3dsm4GxOed4DzMpSSQ8Zjh_OY2jCPEXdp7DHl6yraFiJ4vIP7MUO-wBMMc-kusB08_h0XB6nwYcAJBhvxZKcQo00LnkPOe3iJnnU2Znh1rOfo1_XHn-tP1ebbzef1h00VqCKyUrV1naydt0r5hnuptWfSKwdOEG1tK7RqvKMtY9BQpXWjOWtaRpQVDfU1P0fvDnunNP7bQ55NH7KDcsoA4z4b1WjBa_kAvjmC-7YHb6YU-nKuOb6o6G-Pus3Oxi7ZwYV8wuqaKKJ4wfQBuwsRlpNMiXmIyZSYzGNMZvtj-zgVb3XwhjzD_clr019TK66kuf16Y9Qt2V5vNl_MFf8PUhGVxw</recordid><startdate>198903</startdate><enddate>198903</enddate><creator>Jans, A. 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Psychology</topic><topic>Glucose - metabolism</topic><topic>Glycerol - metabolism</topic><topic>In Vitro Techniques</topic><topic>Kidney Medulla - metabolism</topic><topic>L-Iditol 2-Dehydrogenase - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Other biological molecules</topic><topic>Pentose Phosphate Pathway</topic><topic>Rabbits</topic><topic>Ribose - metabolism</topic><topic>Sorbitol - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jans, A. W. H.</creatorcontrib><creatorcontrib>Grunewald, R.-W.</creatorcontrib><creatorcontrib>Kinne, R. K. 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Med</addtitle><date>1989-03</date><risdate>1989</risdate><volume>9</volume><issue>3</issue><spage>419</spage><epage>422</epage><pages>419-422</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Suspensions of rabbit renal papillary tissue were incubated with D‐[ 6‐13C]glucose, D‐[1‐13C]fructose, D‐[1‐13C] ribose, and [2‐13C]glycerol. The perchloric acid extracts of the above incubations were investigated with 13C NMR spectroscopy. All 13C‐labeled substrates give rise to 13C‐labeled D‐sorbitol. D‐[6‐13C]Glucose and D[1‐13C]fructose are converted directly into D‐sorbitol via the aldose reductase and sorbitol dehydrogenase pathway, respectively, whereas D‐[1‐13C] ribose and [2‐13C]glycerol give rise to labeling of the D‐glyceraldehyde pool which on its turn causes a labeling of D‐sorbitol. Label exchanges observed from incubations with glycerol and D‐ribose indicate that the pentose shunt plays a role in this synthesis of D‐sorbitol. © 1989 Academic Press, Inc.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2496284</pmid><doi>10.1002/mrm.1910090315</doi><tpages>4</tpages></addata></record>
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subjects Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Carbohydrates
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Glycerol - metabolism
In Vitro Techniques
Kidney Medulla - metabolism
L-Iditol 2-Dehydrogenase - metabolism
Magnetic Resonance Spectroscopy
Male
Other biological molecules
Pentose Phosphate Pathway
Rabbits
Ribose - metabolism
Sorbitol - biosynthesis
title Pathways for the synthesis of sorbitol from 13C-labeled hexoses, pentose, and glycerol in renal papillary tissue
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