Alpha 2-antiplasmin causes thrombi to resist fibrinolysis induced by tissue plasminogen activator in experimental pulmonary embolism

In patients with pulmonary embolism, thrombi resist fibrinolysis induced by plasminogen activators. Because the molecular basis of this thrombus resistance is poorly understood, we used a potent inhibitor to examine the potential role of alpha 2-antiplasmin (alpha 2AP) in experimental pulmonary embo...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1997-04, Vol.95 (7), p.1886-1891
Hauptverfasser:	Butte, A N, Houng, A K, Jang, I K, Reed, G L
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-2-Antiplasmin - pharmacology Animals Drug Resistance Ferrets Fibrinolysis - drug effects Heparin - pharmacology Humans Male Mice Mice, Inbred BALB C Plasminogen Activators - pharmacology Plasminogen Activators - therapeutic use Pulmonary Embolism - drug therapy Pulmonary Embolism - physiopathology Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Tissue Plasminogen Activator - pharmacology Tissue Plasminogen Activator - therapeutic use
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