Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors

The multi-functional protein calreticulin (CRT) is normally found within the lumen of the endoplasmic reticulum (ER). However, some of its proposed functions require it to be located within the nucleus, where its presence is contentious. We have investigated this in live COS7, HeLa and LM(TK−) cells...

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Veröffentlicht in:	FEBS letters 1997-03, Vol.405 (2), p.181-185
Hauptverfasser:	Roderick, H.Llewelyn, Campbell, Anthony K, Llewellyn, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Calreticulin Cell Compartmentation Cell Nucleus - metabolism Confocal microscopy COS Cells Dexamethasone - pharmacology Endoplasmic reticulum Endoplasmic Reticulum - metabolism GFP (green fluorescent protein) Glucocorticoid receptor Glucocorticoids - pharmacology Green Fluorescent Proteins HeLa Cells Humans Immunohistochemistry Luminescent Proteins - genetics Nucleus Oligopeptides - genetics Oligopeptides - metabolism Protein Sorting Signals - genetics Protein Sorting Signals - metabolism Receptors, Glucocorticoid - metabolism Recombinant Fusion Proteins - genetics Ribonucleoproteins - genetics Ribonucleoproteins - metabolism
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