Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures
Purpose. The purpose of the study was to compare the efficacy and cost of two antibiotic regimens for prophylaxis of compound mandible fractures: 1 gm/day ceftriaxone and 2 million U penicillin G every 4 hours. Design. A prospective study of 90 patients with compound mandible fractures was performed...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1997-04, Vol.83 (4), p.423-426 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Heit, James M Stevens, Mark R Jeffords, Keith |
| description | Purpose.
The purpose of the study was to compare the efficacy and cost of two antibiotic regimens for prophylaxis of compound mandible fractures: 1 gm/day ceftriaxone and 2 million U penicillin G every 4 hours.
Design.
A prospective study of 90 patients with compound mandible fractures was performed. The patients were randomized to the two antibiotic regimens. The surgical procedures were performed by oral/maxillofacial surgery residents at a large urban training center. Standard treatment consisted of open reduction with either bone plates or wires, with all patients receiving 6 weeks of maxillomandibular fixation. The patients were monitored at 2-week intervals for 8 weeks by two of the authors, who were blinded to which antibiotic regimen the patient was assigned.
Results.
Two patients in each group had postoperative infections within the first 2 weeks of treatment. The infections resolved with local wound care, removal of internal fixation devices, and oral antibiotics. After resolution of the infection each patient had a malunion, which was managed without additional complications. The cost difference between the two treatment regimens was approximately $350 per day.
Conclusion.
Ceftriaxone was noted to be an efficacious and cost-effective treatment alternative to penicillin G for compound mandible fracture antibiotic prophylaxis. |
| doi_str_mv | 10.1016/S1079-2104(97)90139-6 |
| format | Article |
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The purpose of the study was to compare the efficacy and cost of two antibiotic regimens for prophylaxis of compound mandible fractures: 1 gm/day ceftriaxone and 2 million U penicillin G every 4 hours.
Design.
A prospective study of 90 patients with compound mandible fractures was performed. The patients were randomized to the two antibiotic regimens. The surgical procedures were performed by oral/maxillofacial surgery residents at a large urban training center. Standard treatment consisted of open reduction with either bone plates or wires, with all patients receiving 6 weeks of maxillomandibular fixation. The patients were monitored at 2-week intervals for 8 weeks by two of the authors, who were blinded to which antibiotic regimen the patient was assigned.
Results.
Two patients in each group had postoperative infections within the first 2 weeks of treatment. The infections resolved with local wound care, removal of internal fixation devices, and oral antibiotics. After resolution of the infection each patient had a malunion, which was managed without additional complications. The cost difference between the two treatment regimens was approximately $350 per day.
Conclusion.
Ceftriaxone was noted to be an efficacious and cost-effective treatment alternative to penicillin G for compound mandible fracture antibiotic prophylaxis.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/S1079-2104(97)90139-6</identifier><identifier>PMID: 9127371</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Antibiotic Prophylaxis - economics ; Biological and medical sciences ; Ceftriaxone - therapeutic use ; Cephalosporins - therapeutic use ; Child ; Dentistry ; Drug Costs ; Ent. Stomatology ; Female ; Fracture Fixation, Internal ; Fractures, Open - surgery ; Humans ; Male ; Mandibular Fractures - surgery ; Medical sciences ; Middle Aged ; Penicillin G - therapeutic use ; Penicillins - therapeutic use ; Pharmacology. Drug treatments ; Prospective Studies ; Single-Blind Method ; Surgical Wound Infection - prevention & control</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1997-04, Vol.83 (4), p.423-426</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-f37cf42c4d40eeb3db817563493eb8270915b988127cfdb1abd1f2b59beba2503</citedby><cites>FETCH-LOGICAL-c436t-f37cf42c4d40eeb3db817563493eb8270915b988127cfdb1abd1f2b59beba2503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1079-2104(97)90139-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2642132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9127371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heit, James M</creatorcontrib><creatorcontrib>Stevens, Mark R</creatorcontrib><creatorcontrib>Jeffords, Keith</creatorcontrib><title>Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Purpose.
The purpose of the study was to compare the efficacy and cost of two antibiotic regimens for prophylaxis of compound mandible fractures: 1 gm/day ceftriaxone and 2 million U penicillin G every 4 hours.
Design.
A prospective study of 90 patients with compound mandible fractures was performed. The patients were randomized to the two antibiotic regimens. The surgical procedures were performed by oral/maxillofacial surgery residents at a large urban training center. Standard treatment consisted of open reduction with either bone plates or wires, with all patients receiving 6 weeks of maxillomandibular fixation. The patients were monitored at 2-week intervals for 8 weeks by two of the authors, who were blinded to which antibiotic regimen the patient was assigned.
Results.
Two patients in each group had postoperative infections within the first 2 weeks of treatment. The infections resolved with local wound care, removal of internal fixation devices, and oral antibiotics. After resolution of the infection each patient had a malunion, which was managed without additional complications. The cost difference between the two treatment regimens was approximately $350 per day.
Conclusion.
Ceftriaxone was noted to be an efficacious and cost-effective treatment alternative to penicillin G for compound mandible fracture antibiotic prophylaxis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibiotic Prophylaxis - economics</subject><subject>Biological and medical sciences</subject><subject>Ceftriaxone - therapeutic use</subject><subject>Cephalosporins - therapeutic use</subject><subject>Child</subject><subject>Dentistry</subject><subject>Drug Costs</subject><subject>Ent. Stomatology</subject><subject>Female</subject><subject>Fracture Fixation, Internal</subject><subject>Fractures, Open - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Mandibular Fractures - surgery</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Penicillin G - therapeutic use</subject><subject>Penicillins - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Single-Blind Method</subject><subject>Surgical Wound Infection - prevention & control</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrFjEUhgdRalv9CYUsRHQxmsvMZLIS-fAGBRcquAu5nNAjM8mYzNT235vvYreuEnifc87L0zRXjL5hlA1vvzEqVcsZ7V4p-VpRJlQ7PGrOWc_HVqj-5-P6_4c8bS5K-UUpHYRSZ82ZYlwKyc4bv0vzYjKWFEkKxEFYM5q7FIH8wfWGLBDR4TRhJCFlYuKKFtOKjiw5LTf3k7nDcohcXZS26Mlsokc7AQnZuHXLUJ41T4KZCjw_vZfNj48fvu8-t9dfP33Zvb9uXSeGtQ1CutBx1_mOAljh7chkP4hOCbAjl1Sx3qpxrN1d8JYZ61ngtlcWrOE9FZfNy-Pe2u33BmXVMxYH02QipK1oOaqOKsor2B9Bl1MpGYJeMs4m32tG9d6uPtjVe3VaSX2wq4c6d3U6sNkZ_MPUSWfNX5xyU5yZqoDosDxgfOg4E_vz744YVBm3CFkXhxAdeMzgVu0T_qfIXytTmOI</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Heit, James M</creator><creator>Stevens, Mark R</creator><creator>Jeffords, Keith</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures</title><author>Heit, James M ; Stevens, Mark R ; Jeffords, Keith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-f37cf42c4d40eeb3db817563493eb8270915b988127cfdb1abd1f2b59beba2503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibiotic Prophylaxis - economics</topic><topic>Biological and medical sciences</topic><topic>Ceftriaxone - therapeutic use</topic><topic>Cephalosporins - therapeutic use</topic><topic>Child</topic><topic>Dentistry</topic><topic>Drug Costs</topic><topic>Ent. Stomatology</topic><topic>Female</topic><topic>Fracture Fixation, Internal</topic><topic>Fractures, Open - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Mandibular Fractures - surgery</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Penicillin G - therapeutic use</topic><topic>Penicillins - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Single-Blind Method</topic><topic>Surgical Wound Infection - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heit, James M</creatorcontrib><creatorcontrib>Stevens, Mark R</creatorcontrib><creatorcontrib>Jeffords, Keith</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heit, James M</au><au>Stevens, Mark R</au><au>Jeffords, Keith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>83</volume><issue>4</issue><spage>423</spage><epage>426</epage><pages>423-426</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Purpose.
The purpose of the study was to compare the efficacy and cost of two antibiotic regimens for prophylaxis of compound mandible fractures: 1 gm/day ceftriaxone and 2 million U penicillin G every 4 hours.
Design.
A prospective study of 90 patients with compound mandible fractures was performed. The patients were randomized to the two antibiotic regimens. The surgical procedures were performed by oral/maxillofacial surgery residents at a large urban training center. Standard treatment consisted of open reduction with either bone plates or wires, with all patients receiving 6 weeks of maxillomandibular fixation. The patients were monitored at 2-week intervals for 8 weeks by two of the authors, who were blinded to which antibiotic regimen the patient was assigned.
Results.
Two patients in each group had postoperative infections within the first 2 weeks of treatment. The infections resolved with local wound care, removal of internal fixation devices, and oral antibiotics. After resolution of the infection each patient had a malunion, which was managed without additional complications. The cost difference between the two treatment regimens was approximately $350 per day.
Conclusion.
Ceftriaxone was noted to be an efficacious and cost-effective treatment alternative to penicillin G for compound mandible fracture antibiotic prophylaxis.</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>9127371</pmid><doi>10.1016/S1079-2104(97)90139-6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-2104 |
| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1997-04, Vol.83 (4), p.423-426 |
| issn | 1079-2104 1528-395X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78940902 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Antibiotic Prophylaxis - economics Biological and medical sciences Ceftriaxone - therapeutic use Cephalosporins - therapeutic use Child Dentistry Drug Costs Ent. Stomatology Female Fracture Fixation, Internal Fractures, Open - surgery Humans Male Mandibular Fractures - surgery Medical sciences Middle Aged Penicillin G - therapeutic use Penicillins - therapeutic use Pharmacology. Drug treatments Prospective Studies Single-Blind Method Surgical Wound Infection - prevention & control |
| title | Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures |
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