Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

It is not known how the protein Bcl-2 inhibits cell death induced by calcium signalling and growth-factor withdrawal 1–3 . Here we report that Bcl-2 forms a tight complex with calcineurin, resulting in the targeting of calcineurin to Bcl-2 sites on cytoplasmic membranes, and show that this interacti...

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Veröffentlicht in:	Nature (London) 1997-04, Vol.386 (6626), p.728-731
Hauptverfasser:	Shibasaki, Futoshi, Kondo, Eisaku, Akagi, Tadaatsu, McKeon, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Amino Acid Sequence Animals B-Lymphocytes - metabolism bcl-2-Associated X Protein Binding Sites Biochemistry Biological and medical sciences Biological Transport Calcineurin Calmodulin-Binding Proteins - metabolism Cell Line Cell Nucleus - metabolism Cell physiology Cellular biology Consensus Sequence Cricetinae DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Humans Intracellular Membranes - metabolism letter Molecular and cellular biology Molecular Sequence Data multidisciplinary NFATC Transcription Factors Nuclear Proteins Phosphoprotein Phosphatases - metabolism Protein Binding Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Science Science (multidisciplinary) Sequence Alignment Signal Transduction T-Lymphocytes - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Translocation
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