Morelloflavone, a novel biflavonoid inhibitor of human secretory phospholipase A2 with anti-inflammatory activity

The flavanonylflavone morelloflavone inhibited secretory phospholipase A2 (PLA2) in vitro, with a high potency on the human recombinant synovial and bee venom enzymes (IC50 = 0.9 and 0.6 microM, respectively). The inhibition was apparently irreversible. In contrast, the compound was inactive on cyto...

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Veröffentlicht in:	Biochemical pharmacology 1997-03, Vol.53 (5), p.733-740
Hauptverfasser:	GIL, B, SANZ, M. J, TERENCIO, M. C, GUNASEGARAN, R, PAYA, M, ALCARAZ, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Biflavonoids Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Flavonoids - pharmacology Humans Luminescent Measurements Medical sciences Mice Pharmacology. Drug treatments Phospholipases A - antagonists & inhibitors Phospholipases A2
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