Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus
Mating behavior in male hamsters is initiated by pheromones, detected by two chemosensory systems which converge on the medial nucleus of the amygdala and the bed nucleus of the stria terminalis. Neurons in these areas project to the medial preoptic nucleus. All three of these areas contain androgen...
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| Veröffentlicht in: | Brain research 1997-03, Vol.750 (1), p.189-194 |
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| creator | Swann, Jennifer M |
| description | Mating behavior in male hamsters is initiated by pheromones, detected by two chemosensory systems which converge on the medial nucleus of the amygdala and the bed nucleus of the stria terminalis. Neurons in these areas project to the medial preoptic nucleus. All three of these areas contain androgen receptors. Using Fos as a marker of stimulation we have found that pheromones stimulate neurons in all three areas in intact males but fail to stimulate the magnocellular division of the medial preoptic nucleus of castrates. As this area plays a critical role in the regulation of male mating behavior our results suggest that steroids regulate mating by maintaining the responsiveness of the magnocellular division of the medial preoptic nucleus to pheromones. |
| doi_str_mv | 10.1016/S0006-8993(96)01348-0 |
| format | Article |
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Neurons in these areas project to the medial preoptic nucleus. All three of these areas contain androgen receptors. Using Fos as a marker of stimulation we have found that pheromones stimulate neurons in all three areas in intact males but fail to stimulate the magnocellular division of the medial preoptic nucleus of castrates. As this area plays a critical role in the regulation of male mating behavior our results suggest that steroids regulate mating by maintaining the responsiveness of the magnocellular division of the medial preoptic nucleus to pheromones.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(96)01348-0</identifier><identifier>PMID: 9098544</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Bed nucleus of the stria terminalis ; Biomarkers ; Brain Mapping ; Copulation ; Cricetinae ; Female ; Fos ; Male ; Mating behavior ; Medial nucleus of the amygdala ; Medial preoptic area ; Mesocricetus ; Models, Neurological ; Models, Psychological ; Neurons - drug effects ; Neurons - physiology ; Olfactory Bulb - physiology ; Orchiectomy ; Pheromones - metabolism ; Pheromones - pharmacology ; Preoptic Area - drug effects ; Preoptic Area - physiology ; Proto-Oncogene Proteins c-fos - biosynthesis ; Sexual Behavior, Animal - physiology ; Testosterone ; Testosterone - pharmacology ; Vagina - metabolism</subject><ispartof>Brain research, 1997-03, Vol.750 (1), p.189-194</ispartof><rights>1997 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-22056b45d83b324ed62e1691ace00bdb45eadc7f94818ffdd61fc8d063f21e943</citedby><cites>FETCH-LOGICAL-c391t-22056b45d83b324ed62e1691ace00bdb45eadc7f94818ffdd61fc8d063f21e943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(96)01348-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9098544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swann, Jennifer M</creatorcontrib><title>Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Mating behavior in male hamsters is initiated by pheromones, detected by two chemosensory systems which converge on the medial nucleus of the amygdala and the bed nucleus of the stria terminalis. Neurons in these areas project to the medial preoptic nucleus. All three of these areas contain androgen receptors. Using Fos as a marker of stimulation we have found that pheromones stimulate neurons in all three areas in intact males but fail to stimulate the magnocellular division of the medial preoptic nucleus of castrates. As this area plays a critical role in the regulation of male mating behavior our results suggest that steroids regulate mating by maintaining the responsiveness of the magnocellular division of the medial preoptic nucleus to pheromones.</description><subject>Animals</subject><subject>Bed nucleus of the stria terminalis</subject><subject>Biomarkers</subject><subject>Brain Mapping</subject><subject>Copulation</subject><subject>Cricetinae</subject><subject>Female</subject><subject>Fos</subject><subject>Male</subject><subject>Mating behavior</subject><subject>Medial nucleus of the amygdala</subject><subject>Medial preoptic area</subject><subject>Mesocricetus</subject><subject>Models, Neurological</subject><subject>Models, Psychological</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Olfactory Bulb - physiology</subject><subject>Orchiectomy</subject><subject>Pheromones - metabolism</subject><subject>Pheromones - pharmacology</subject><subject>Preoptic Area - drug effects</subject><subject>Preoptic Area - physiology</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Testosterone</subject><subject>Testosterone - pharmacology</subject><subject>Vagina - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFP3DAQha0KBMu2PwHJp4oeUuw48dqnqloVWgmpB-BsOfaka5SNU4-ziH-Pl11x5TSaed_MSO8RcsnZd864vL5njMlKaS2utPzGuGhUxT6RBVerupJ1w07I4h05JxeIT6UVQrMzcqaZVm3TLMjzbRyttwPFDCkGjzTBv3mwGWgHG7sLMRUxAU5xRECaI502hdzGsXTdC7UuhyLROFJLce582AUsExp7mjdAt-BDuTAliFMOjo6zG2DGz-S0twPCl2NdksebXw_r39Xd39s_6593lROa56quWSu7pvVKdKJuwMsauNTcOmCs80UB692q143iqu-9l7x3yjMp-pqDbsSSfD3cnVL8PwNmsw3oYBjsCHFGs1JaqFVx7yOQt0rptmYFbA-gSxExQW-mFLY2vRjOzD4Z85aM2dtutDRvyZj93uXxwdwVU963jlEU_cdBh2LHLkAy6AKMrviXwGXjY_jgwyuRqaBF</recordid><startdate>19970307</startdate><enddate>19970307</enddate><creator>Swann, Jennifer M</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19970307</creationdate><title>Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus</title><author>Swann, Jennifer M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-22056b45d83b324ed62e1691ace00bdb45eadc7f94818ffdd61fc8d063f21e943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Bed nucleus of the stria terminalis</topic><topic>Biomarkers</topic><topic>Brain Mapping</topic><topic>Copulation</topic><topic>Cricetinae</topic><topic>Female</topic><topic>Fos</topic><topic>Male</topic><topic>Mating behavior</topic><topic>Medial nucleus of the amygdala</topic><topic>Medial preoptic area</topic><topic>Mesocricetus</topic><topic>Models, Neurological</topic><topic>Models, Psychological</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Olfactory Bulb - physiology</topic><topic>Orchiectomy</topic><topic>Pheromones - metabolism</topic><topic>Pheromones - pharmacology</topic><topic>Preoptic Area - drug effects</topic><topic>Preoptic Area - physiology</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Testosterone</topic><topic>Testosterone - pharmacology</topic><topic>Vagina - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swann, Jennifer M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swann, Jennifer M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1997-03-07</date><risdate>1997</risdate><volume>750</volume><issue>1</issue><spage>189</spage><epage>194</epage><pages>189-194</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Mating behavior in male hamsters is initiated by pheromones, detected by two chemosensory systems which converge on the medial nucleus of the amygdala and the bed nucleus of the stria terminalis. Neurons in these areas project to the medial preoptic nucleus. All three of these areas contain androgen receptors. Using Fos as a marker of stimulation we have found that pheromones stimulate neurons in all three areas in intact males but fail to stimulate the magnocellular division of the medial preoptic nucleus of castrates. As this area plays a critical role in the regulation of male mating behavior our results suggest that steroids regulate mating by maintaining the responsiveness of the magnocellular division of the medial preoptic nucleus to pheromones.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9098544</pmid><doi>10.1016/S0006-8993(96)01348-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1997-03, Vol.750 (1), p.189-194 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Bed nucleus of the stria terminalis Biomarkers Brain Mapping Copulation Cricetinae Female Fos Male Mating behavior Medial nucleus of the amygdala Medial preoptic area Mesocricetus Models, Neurological Models, Psychological Neurons - drug effects Neurons - physiology Olfactory Bulb - physiology Orchiectomy Pheromones - metabolism Pheromones - pharmacology Preoptic Area - drug effects Preoptic Area - physiology Proto-Oncogene Proteins c-fos - biosynthesis Sexual Behavior, Animal - physiology Testosterone Testosterone - pharmacology Vagina - metabolism |
| title | Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus |
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