Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells

Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells. Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10–300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorb...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-03, Vol.159 (3), p.1435-1440
Hauptverfasser:	Kurihara, Hiroki, Yoshizumi, Masao, Sugiyama, Takao, Takaku, Fumimaro, Yanagisawa, Masashi, Masaki, Tomoh, Hamaoki, Masaru, Kato, Hirohisa, Yazaki, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic Biological and medical sciences Cell physiology Cells, Cultured Endothelins Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Kinetics Molecular and cellular biology Peptides - genetics Responses to growth factors, tumor promotors, other factors RNA, Messenger - drug effects RNA, Messenger - genetics Swine Transcription, Genetic - drug effects Transforming Growth Factors - pharmacology
Online-Zugang:	Volltext
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