Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells
Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells. Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10–300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorb...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1989-03, Vol.159 (3), p.1435-1440 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 159 |
| creator | Kurihara, Hiroki Yoshizumi, Masao Sugiyama, Takao Takaku, Fumimaro Yanagisawa, Masashi Masaki, Tomoh Hamaoki, Masaru Kato, Hirohisa Yazaki, Yoshio |
| description | Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells. Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10–300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-β1. These results suggest that TGF-β1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells. |
| doi_str_mv | 10.1016/0006-291X(89)92270-5 |
| format | Article |
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Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10–300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-β1. 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Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10–300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-β1. These results suggest that TGF-β1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells.</description><subject>Animals</subject><subject>Aorta, Thoracic</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>Endothelins</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. 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Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10–300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-β1. These results suggest that TGF-β1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2649101</pmid><doi>10.1016/0006-291X(89)92270-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1989-03, Vol.159 (3), p.1435-1440 |
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| subjects | Animals Aorta, Thoracic Biological and medical sciences Cell physiology Cells, Cultured Endothelins Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Kinetics Molecular and cellular biology Peptides - genetics Responses to growth factors, tumor promotors, other factors RNA, Messenger - drug effects RNA, Messenger - genetics Swine Transcription, Genetic - drug effects Transforming Growth Factors - pharmacology |
| title | Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells |
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