Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism
Objective: To evaluate whether ovarian function might have an influence on the adrenal hyperandrogenism present in patients with functional ovarian hyperandrogenism. Design: Controlled clinical study. Setting: Tertiary institutional hospital. Patient(s): Twenty-nine hirsute women with functional ova...
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| Veröffentlicht in: | Fertility and sterility 1997-04, Vol.67 (4), p.654-662 |
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| creator | Escobar-Morreale, Héctor F. Serrano-Gotarredona, Joaquin Garcia-Robles, Rafael Sancho, JoséM. Varela, César |
| description | Objective: To evaluate whether ovarian function might have an influence on the adrenal hyperandrogenism present in patients with functional ovarian hyperandrogenism.
Design: Controlled clinical study.
Setting: Tertiary institutional hospital.
Patient(s): Twenty-nine hirsute women with functional ovarian hyperandrogenism and 12 normal controls.
Intervention(s): The ACTH and GnRH tests were performed before and during triptorelininduced ovarian suppression in patients. The normal women served as controls for the ACTH test.
Main Outcome Measure(s): Basal and ACTH-stimulated steroid values.
Result(s): All patients presented elevated T and free androgen index, which normalized after triptorelin. Patients with functional ovarian hyperandrogenism and adrenal hyperandrogenism, defined by elevated basal DHEAS (n = 10), presented enhanced
Δ
4-17,20-lyase activity, which persisted during ovarian suppression.
Δ
4-17,20-lyase activity was normal in the functional ovarian hyperandrogenism patients without adrenal hyperandrogenism (n = 19). No correlation was observed between the any of the indexes of the adrenal enzymatic activities evaluated and plasma E
2 or T.
Conclusion(s): Increased adrenal Δ
4-17,20-lyase activity is present in functional ovarian hyperandrogenism women with adrenal hyperandrogenism. No influence of the excess ovarian androgens or estrogens was found on any of the adrenal enzymatic pathways explored. |
| doi_str_mv | 10.1016/S0015-0282(97)81362-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78936662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028297813623</els_id><sourcerecordid>78936662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-9b036f23006317ba105e5403fcc44bebf77bb2618bb9e62250cc25c4e8e4df9b3</originalsourceid><addsrcrecordid>eNqFUctO3DAUtaoimNJ-AlIWqIJFih-xE68qhKCtNBIL2rVlO9cdt4k9tRMQ38BP43kw266u7PO49jkInRH8hWAirh4wJrzGtKMXsr3sCBO0Zu_QgnAuai44e48WB8oJ-pDzH4yxIC09RscSS0YkXqCXpbZ_q-gqHar4qJMv083BTj6Gygc3zBAsVOUwraBc2AQ6Q1_pPkHQQ5H1Kf6GUGUo0Fa1TpAhTIVcPcWxQE9-Wh1Mi-Ztz-p5DenNwOfxIzpyesjwaT9P0a-725833-vl_bcfN9fL2jaCT7U0mAlHWfkMI63RBHPgDWbO2qYxYFzbGkMF6YyRICjl2FrKbQMdNL2Thp2izzvfdYr_ZsiTGn22MAw6QJyzajvJhBC0EPmOaFPMOYFT6-RHnZ4VwWpTgtqWoDYJK9mqbQmKFd3ZfsFsRugPqn3qBT_f4zpbPbgSgvX5QKOCiVY0hfZ1R4MSxqOHpLL1mzp6n8BOqo_-Pw95Bf0VpqM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78936662</pqid></control><display><type>article</type><title>Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Escobar-Morreale, Héctor F. ; Serrano-Gotarredona, Joaquin ; Garcia-Robles, Rafael ; Sancho, JoséM. ; Varela, César</creator><creatorcontrib>Escobar-Morreale, Héctor F. ; Serrano-Gotarredona, Joaquin ; Garcia-Robles, Rafael ; Sancho, JoséM. ; Varela, César</creatorcontrib><description>Objective: To evaluate whether ovarian function might have an influence on the adrenal hyperandrogenism present in patients with functional ovarian hyperandrogenism.
Design: Controlled clinical study.
Setting: Tertiary institutional hospital.
Patient(s): Twenty-nine hirsute women with functional ovarian hyperandrogenism and 12 normal controls.
Intervention(s): The ACTH and GnRH tests were performed before and during triptorelininduced ovarian suppression in patients. The normal women served as controls for the ACTH test.
Main Outcome Measure(s): Basal and ACTH-stimulated steroid values.
Result(s): All patients presented elevated T and free androgen index, which normalized after triptorelin. Patients with functional ovarian hyperandrogenism and adrenal hyperandrogenism, defined by elevated basal DHEAS (n = 10), presented enhanced
Δ
4-17,20-lyase activity, which persisted during ovarian suppression.
Δ
4-17,20-lyase activity was normal in the functional ovarian hyperandrogenism patients without adrenal hyperandrogenism (n = 19). No correlation was observed between the any of the indexes of the adrenal enzymatic activities evaluated and plasma E
2 or T.
Conclusion(s): Increased adrenal Δ
4-17,20-lyase activity is present in functional ovarian hyperandrogenism women with adrenal hyperandrogenism. No influence of the excess ovarian androgens or estrogens was found on any of the adrenal enzymatic pathways explored.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(97)81362-3</identifier><identifier>PMID: 9093190</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>20-lyase ovary ; Adolescent ; adrenal ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adrenocortical Hyperfunction - blood ; Adrenocortical Hyperfunction - enzymology ; adrenocorticotropin stimulation test ; Adult ; Androgens - metabolism ; Biological and medical sciences ; Cohort Studies ; Cosyntropin - administration & dosage ; cytochrome P450c17α ; Delayed-Action Preparations ; Endocrinopathies ; Female ; Follicular Phase - drug effects ; Follicular Phase - physiology ; Gonadotropin-Releasing Hormone - administration & dosage ; Gonadotropin-releasing hormone agonist ; hirsutism ; Humans ; hyperandrogenism ; Hyperandrogenism - blood ; Hyperandrogenism - enzymology ; Luteolytic Agents - administration & dosage ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Ovarian Diseases - blood ; Ovarian Diseases - enzymology ; Reference Values ; Steroid 17-alpha-Hydroxylase - blood ; Steroid 17-alpha-Hydroxylase - drug effects ; Steroids - blood ; Triptorelin Pamoate - administration & dosage</subject><ispartof>Fertility and sterility, 1997-04, Vol.67 (4), p.654-662</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-9b036f23006317ba105e5403fcc44bebf77bb2618bb9e62250cc25c4e8e4df9b3</citedby><cites>FETCH-LOGICAL-c465t-9b036f23006317ba105e5403fcc44bebf77bb2618bb9e62250cc25c4e8e4df9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028297813623$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3536,23910,23911,25119,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2636764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9093190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Escobar-Morreale, Héctor F.</creatorcontrib><creatorcontrib>Serrano-Gotarredona, Joaquin</creatorcontrib><creatorcontrib>Garcia-Robles, Rafael</creatorcontrib><creatorcontrib>Sancho, JoséM.</creatorcontrib><creatorcontrib>Varela, César</creatorcontrib><title>Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To evaluate whether ovarian function might have an influence on the adrenal hyperandrogenism present in patients with functional ovarian hyperandrogenism.
Design: Controlled clinical study.
Setting: Tertiary institutional hospital.
Patient(s): Twenty-nine hirsute women with functional ovarian hyperandrogenism and 12 normal controls.
Intervention(s): The ACTH and GnRH tests were performed before and during triptorelininduced ovarian suppression in patients. The normal women served as controls for the ACTH test.
Main Outcome Measure(s): Basal and ACTH-stimulated steroid values.
Result(s): All patients presented elevated T and free androgen index, which normalized after triptorelin. Patients with functional ovarian hyperandrogenism and adrenal hyperandrogenism, defined by elevated basal DHEAS (n = 10), presented enhanced
Δ
4-17,20-lyase activity, which persisted during ovarian suppression.
Δ
4-17,20-lyase activity was normal in the functional ovarian hyperandrogenism patients without adrenal hyperandrogenism (n = 19). No correlation was observed between the any of the indexes of the adrenal enzymatic activities evaluated and plasma E
2 or T.
Conclusion(s): Increased adrenal Δ
4-17,20-lyase activity is present in functional ovarian hyperandrogenism women with adrenal hyperandrogenism. No influence of the excess ovarian androgens or estrogens was found on any of the adrenal enzymatic pathways explored.</description><subject>20-lyase ovary</subject><subject>Adolescent</subject><subject>adrenal</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adrenocortical Hyperfunction - blood</subject><subject>Adrenocortical Hyperfunction - enzymology</subject><subject>adrenocorticotropin stimulation test</subject><subject>Adult</subject><subject>Androgens - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Cosyntropin - administration & dosage</subject><subject>cytochrome P450c17α</subject><subject>Delayed-Action Preparations</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follicular Phase - drug effects</subject><subject>Follicular Phase - physiology</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Gonadotropin-releasing hormone agonist</subject><subject>hirsutism</subject><subject>Humans</subject><subject>hyperandrogenism</subject><subject>Hyperandrogenism - blood</subject><subject>Hyperandrogenism - enzymology</subject><subject>Luteolytic Agents - administration & dosage</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Ovarian Diseases - blood</subject><subject>Ovarian Diseases - enzymology</subject><subject>Reference Values</subject><subject>Steroid 17-alpha-Hydroxylase - blood</subject><subject>Steroid 17-alpha-Hydroxylase - drug effects</subject><subject>Steroids - blood</subject><subject>Triptorelin Pamoate - administration & dosage</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctO3DAUtaoimNJ-AlIWqIJFih-xE68qhKCtNBIL2rVlO9cdt4k9tRMQ38BP43kw266u7PO49jkInRH8hWAirh4wJrzGtKMXsr3sCBO0Zu_QgnAuai44e48WB8oJ-pDzH4yxIC09RscSS0YkXqCXpbZ_q-gqHar4qJMv083BTj6Gygc3zBAsVOUwraBc2AQ6Q1_pPkHQQ5H1Kf6GUGUo0Fa1TpAhTIVcPcWxQE9-Wh1Mi-Ztz-p5DenNwOfxIzpyesjwaT9P0a-725833-vl_bcfN9fL2jaCT7U0mAlHWfkMI63RBHPgDWbO2qYxYFzbGkMF6YyRICjl2FrKbQMdNL2Thp2izzvfdYr_ZsiTGn22MAw6QJyzajvJhBC0EPmOaFPMOYFT6-RHnZ4VwWpTgtqWoDYJK9mqbQmKFd3ZfsFsRugPqn3qBT_f4zpbPbgSgvX5QKOCiVY0hfZ1R4MSxqOHpLL1mzp6n8BOqo_-Pw95Bf0VpqM</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Escobar-Morreale, Héctor F.</creator><creator>Serrano-Gotarredona, Joaquin</creator><creator>Garcia-Robles, Rafael</creator><creator>Sancho, JoséM.</creator><creator>Varela, César</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism</title><author>Escobar-Morreale, Héctor F. ; Serrano-Gotarredona, Joaquin ; Garcia-Robles, Rafael ; Sancho, JoséM. ; Varela, César</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-9b036f23006317ba105e5403fcc44bebf77bb2618bb9e62250cc25c4e8e4df9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>20-lyase ovary</topic><topic>Adolescent</topic><topic>adrenal</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adrenocortical Hyperfunction - blood</topic><topic>Adrenocortical Hyperfunction - enzymology</topic><topic>adrenocorticotropin stimulation test</topic><topic>Adult</topic><topic>Androgens - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Cosyntropin - administration & dosage</topic><topic>cytochrome P450c17α</topic><topic>Delayed-Action Preparations</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Follicular Phase - drug effects</topic><topic>Follicular Phase - physiology</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Gonadotropin-releasing hormone agonist</topic><topic>hirsutism</topic><topic>Humans</topic><topic>hyperandrogenism</topic><topic>Hyperandrogenism - blood</topic><topic>Hyperandrogenism - enzymology</topic><topic>Luteolytic Agents - administration & dosage</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Ovarian Diseases - blood</topic><topic>Ovarian Diseases - enzymology</topic><topic>Reference Values</topic><topic>Steroid 17-alpha-Hydroxylase - blood</topic><topic>Steroid 17-alpha-Hydroxylase - drug effects</topic><topic>Steroids - blood</topic><topic>Triptorelin Pamoate - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escobar-Morreale, Héctor F.</creatorcontrib><creatorcontrib>Serrano-Gotarredona, Joaquin</creatorcontrib><creatorcontrib>Garcia-Robles, Rafael</creatorcontrib><creatorcontrib>Sancho, JoséM.</creatorcontrib><creatorcontrib>Varela, César</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escobar-Morreale, Héctor F.</au><au>Serrano-Gotarredona, Joaquin</au><au>Garcia-Robles, Rafael</au><au>Sancho, JoséM.</au><au>Varela, César</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>67</volume><issue>4</issue><spage>654</spage><epage>662</epage><pages>654-662</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To evaluate whether ovarian function might have an influence on the adrenal hyperandrogenism present in patients with functional ovarian hyperandrogenism.
Design: Controlled clinical study.
Setting: Tertiary institutional hospital.
Patient(s): Twenty-nine hirsute women with functional ovarian hyperandrogenism and 12 normal controls.
Intervention(s): The ACTH and GnRH tests were performed before and during triptorelininduced ovarian suppression in patients. The normal women served as controls for the ACTH test.
Main Outcome Measure(s): Basal and ACTH-stimulated steroid values.
Result(s): All patients presented elevated T and free androgen index, which normalized after triptorelin. Patients with functional ovarian hyperandrogenism and adrenal hyperandrogenism, defined by elevated basal DHEAS (n = 10), presented enhanced
Δ
4-17,20-lyase activity, which persisted during ovarian suppression.
Δ
4-17,20-lyase activity was normal in the functional ovarian hyperandrogenism patients without adrenal hyperandrogenism (n = 19). No correlation was observed between the any of the indexes of the adrenal enzymatic activities evaluated and plasma E
2 or T.
Conclusion(s): Increased adrenal Δ
4-17,20-lyase activity is present in functional ovarian hyperandrogenism women with adrenal hyperandrogenism. No influence of the excess ovarian androgens or estrogens was found on any of the adrenal enzymatic pathways explored.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9093190</pmid><doi>10.1016/S0015-0282(97)81362-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1997-04, Vol.67 (4), p.654-662 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 20-lyase ovary Adolescent adrenal Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adrenocortical Hyperfunction - blood Adrenocortical Hyperfunction - enzymology adrenocorticotropin stimulation test Adult Androgens - metabolism Biological and medical sciences Cohort Studies Cosyntropin - administration & dosage cytochrome P450c17α Delayed-Action Preparations Endocrinopathies Female Follicular Phase - drug effects Follicular Phase - physiology Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-releasing hormone agonist hirsutism Humans hyperandrogenism Hyperandrogenism - blood Hyperandrogenism - enzymology Luteolytic Agents - administration & dosage Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Ovarian Diseases - blood Ovarian Diseases - enzymology Reference Values Steroid 17-alpha-Hydroxylase - blood Steroid 17-alpha-Hydroxylase - drug effects Steroids - blood Triptorelin Pamoate - administration & dosage |
| title | Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism |
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