Inotropic responses to cyclic nucleotide phosphodiesterase inhibitors in immature and adult rabbit myocardium

Contractile dose-response relationships for amrinone, milrinone, piroximone, and sulmazole were compared in right ventricular papillary muscles isolated from adult and 14-16-day-old immature rabbits. These drugs were effective inotropic agents in immature myocardium as evidenced by substantial incre...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1989, Vol.13 (1), p.146-154
Hauptverfasser:	ARTMAN, M, KITHAS, P. A, WIKE, J. S, CRUMP, D. B, STRADA, S. J
Format:	Artikel
Sprache:	eng
Schlagworte:	2',3'-Cyclic-Nucleotide Phosphodiesterases - antagonists & inhibitors 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism Aging - metabolism Animals Biological and medical sciences Cardiotonic agents Cardiovascular system Cytosol - enzymology Female In Vitro Techniques Male Medical sciences Myocardial Contraction - drug effects Myocardium - enzymology Papillary Muscles - drug effects Papillary Muscles - enzymology Papillary Muscles - metabolism Pharmacology. Drug treatments Rabbits
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