Control of hepatic gluconeogenesis: Role of fatty acid oxidation

Octanoate has been found to activate the gluconeogenic pathway in perfused isolated rat liver. Whether a net increase in the production of glucose is observed is a function of the relative concentrations of the glucose precursor and the fatty acid. The kinetics of octanoate interaction with the gluc...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1989-05, Vol.271 (1), p.1-9
Hauptverfasser:	González-Manchón, Consuelo, Ayuso, Matilde S., Parrilla, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport - drug effects Caprylates - pharmacology Cell metabolism, cell oxidation Cell physiology Dose-Response Relationship, Drug fatty acids Fundamental and applied biological sciences. Psychology gluconeogenesis Gluconeogenesis - drug effects Glucose - biosynthesis Ketones - biosynthesis Kinetics Lactates - pharmacology Liver - drug effects Liver - metabolism Male Mitochondria, Liver - metabolism Molecular and cellular biology NAD - metabolism Oxidation-Reduction Oxygen Consumption - drug effects Perfusion Pyruvates - metabolism Rats Rats, Inbred Strains
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