Dynamics and thermodynamics of the counterion effect in 7H-pyridocarbazole dimer (ditercalinium). Hypothesis of a nonbisintercalative binding mode to calf thymus DNA at high drug base ratio

Ditercalinium, a 7H-pyridocarbazole dimer designed to bisintercalate into DNA, forms tight ion pairs in water with inorganic and organic anions. The thermodynamics and kinetics of the acetate-ditercalinium pairing has been investigated by means of T-jump spectroscopy. The formation of the pair has a...

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Veröffentlicht in:	Journal of medicinal chemistry 1989-05, Vol.32 (5), p.1127-1134
1. Verfasser:	Dodin, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbazoles - metabolism Carbazoles - pharmacology Chemistry DNA - metabolism Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Hydrogen-Ion Concentration Intercalating Agents - metabolism Kinetics Organic chemistry Preparations and properties Thermodynamics
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