Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system
The ontogenetic expression of chromogranin A (CgA) and its derived peptides, WE-14 and pancreastatin (PST), was studied in the rat neuroendocrine system employing immunohistochemical analysis of fetal and neonatal specimens from 12.5-day embryos (E12.5), to 42-day postnatal (P42) rats. CgA immunosta...
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| Veröffentlicht in: | Histochemistry and cell biology 1997-03, Vol.107 (3), p.251-257 |
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| description | The ontogenetic expression of chromogranin A (CgA) and its derived peptides, WE-14 and pancreastatin (PST), was studied in the rat neuroendocrine system employing immunohistochemical analysis of fetal and neonatal specimens from 12.5-day embryos (E12.5), to 42-day postnatal (P42) rats. CgA immunostaining was first detected in endocrine cells of the pancreas, stomach, intestine, adrenal gland and thyroid at E13.5, E14.5, E15.5, E15.5 and E18.5, respectively. PST-like immunoreactivity was detected in endocrine cells of the pancreas at E13.5, stomach, intestine at E15.5, adrenal gland at E17.5 and thyroid at E18.5. WE-14 immunoreactivity was first observed in the immature pancreas at E15.5, mucosal cells of the stomach at E15.5, scattered chromaffin cells in the immature adrenal gland and mucosal cells of the intestine at E17.5 and thyroid parafollicular cells at E18.5. These data confirm that the translation of the CgA gene is regulated differentially in various neuroendocrine tissues and, moreover, suggests that the post-translational processing of the molecule is developmentally controlled. |
| doi_str_mv | 10.1007/s004180050110 |
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CgA immunostaining was first detected in endocrine cells of the pancreas, stomach, intestine, adrenal gland and thyroid at E13.5, E14.5, E15.5, E15.5 and E18.5, respectively. PST-like immunoreactivity was detected in endocrine cells of the pancreas at E13.5, stomach, intestine at E15.5, adrenal gland at E17.5 and thyroid at E18.5. WE-14 immunoreactivity was first observed in the immature pancreas at E15.5, mucosal cells of the stomach at E15.5, scattered chromaffin cells in the immature adrenal gland and mucosal cells of the intestine at E17.5 and thyroid parafollicular cells at E18.5. These data confirm that the translation of the CgA gene is regulated differentially in various neuroendocrine tissues and, moreover, suggests that the post-translational processing of the molecule is developmentally controlled.</description><identifier>ISSN: 0948-6143</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/s004180050110</identifier><identifier>PMID: 9105896</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adrenal glands ; Adrenal Medulla - embryology ; Adrenal Medulla - metabolism ; Animals ; C cells ; Central Nervous System - embryology ; Central Nervous System - metabolism ; CGA gene ; Chromaffin cells ; Chromogranin A ; Chromogranins - metabolism ; Digestive System - embryology ; Digestive System - metabolism ; Embryos ; Female ; Fetuses ; Immune Sera ; Immunoreactivity ; Immunosorbent Techniques ; Intestine ; Mucosa ; Neonates ; Neoplasm Proteins - metabolism ; Neuroendocrine system ; Neurosecretory Systems - embryology ; Neurosecretory Systems - metabolism ; Ontogeny ; Pancreas ; Pancreas - embryology ; Pancreas - metabolism ; Pancreatic Hormones - metabolism ; Peptides ; Pregnancy ; Rats ; Rats, Wistar ; Stomach ; Thyroid ; Thyroid gland ; Thyroid Gland - embryology ; Thyroid Gland - metabolism</subject><ispartof>Histochemistry and cell biology, 1997-03, Vol.107 (3), p.251-257</ispartof><rights>Springer-Verlag Berlin Heidelberg 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-452a16a32d490a4e01c75b03bf077f4e00db8b9e38d85532a03c8636988b9643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9105896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barkatullah, S C</creatorcontrib><creatorcontrib>Curry, W J</creatorcontrib><creatorcontrib>Johnston, C F</creatorcontrib><creatorcontrib>Hutton, J C</creatorcontrib><creatorcontrib>Buchanan, K D</creatorcontrib><title>Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system</title><title>Histochemistry and cell biology</title><addtitle>Histochem Cell Biol</addtitle><description>The ontogenetic expression of chromogranin A (CgA) and its derived peptides, WE-14 and pancreastatin (PST), was studied in the rat neuroendocrine system employing immunohistochemical analysis of fetal and neonatal specimens from 12.5-day embryos (E12.5), to 42-day postnatal (P42) rats. CgA immunostaining was first detected in endocrine cells of the pancreas, stomach, intestine, adrenal gland and thyroid at E13.5, E14.5, E15.5, E15.5 and E18.5, respectively. PST-like immunoreactivity was detected in endocrine cells of the pancreas at E13.5, stomach, intestine at E15.5, adrenal gland at E17.5 and thyroid at E18.5. WE-14 immunoreactivity was first observed in the immature pancreas at E15.5, mucosal cells of the stomach at E15.5, scattered chromaffin cells in the immature adrenal gland and mucosal cells of the intestine at E17.5 and thyroid parafollicular cells at E18.5. These data confirm that the translation of the CgA gene is regulated differentially in various neuroendocrine tissues and, moreover, suggests that the post-translational processing of the molecule is developmentally controlled.</description><subject>Adrenal glands</subject><subject>Adrenal Medulla - embryology</subject><subject>Adrenal Medulla - metabolism</subject><subject>Animals</subject><subject>C cells</subject><subject>Central Nervous System - embryology</subject><subject>Central Nervous System - metabolism</subject><subject>CGA gene</subject><subject>Chromaffin cells</subject><subject>Chromogranin A</subject><subject>Chromogranins - metabolism</subject><subject>Digestive System - embryology</subject><subject>Digestive System - metabolism</subject><subject>Embryos</subject><subject>Female</subject><subject>Fetuses</subject><subject>Immune Sera</subject><subject>Immunoreactivity</subject><subject>Immunosorbent Techniques</subject><subject>Intestine</subject><subject>Mucosa</subject><subject>Neonates</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neuroendocrine system</subject><subject>Neurosecretory Systems - embryology</subject><subject>Neurosecretory Systems - metabolism</subject><subject>Ontogeny</subject><subject>Pancreas</subject><subject>Pancreas - embryology</subject><subject>Pancreas - metabolism</subject><subject>Pancreatic Hormones - metabolism</subject><subject>Peptides</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stomach</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - embryology</subject><subject>Thyroid Gland - metabolism</subject><issn>0948-6143</issn><issn>1432-119X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc1LHTEUxUOx6NN22WUhIHTltDcfk0mWIlYFwY3Q7oZMckcjb5IxyUiF_vGd6qNgV5d77u8eDhxCPjH4ygC6bwVAMg3QAmPwjmyYFLxhzPzcIxswUjdqVQ7IYSkPAKw1nO-TfcOg1UZtyO-bWNMdRqzBUfw1ZywlpEjTSN19TlO6yzaGSE-pjZ6GWqjHHJ7Q0xnnGjyWE_rjvGHy5T7b6DLaUm0N8YSuf_UeabaVRlxywuiTyyEiLc-l4vSBvB_ttuDH3Twit9_Pb88um-ubi6uz0-vGCaZqI1tumbKCe2nASgTmunYAMYzQdeO6gx_0YFBor9tWcAvCaSWU0auqpDgiX15t55weFyy1n0JxuN3aiGkpfacN75TqVvD4P_AhLTmu0XouoWtBcNAr1bxSLqdSMo79nMNk83PPoP9bSf-mkpX_vHNdhgn9P3rXgfgD4E6FzQ</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Barkatullah, S C</creator><creator>Curry, W J</creator><creator>Johnston, C F</creator><creator>Hutton, J C</creator><creator>Buchanan, K D</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system</title><author>Barkatullah, S C ; Curry, W J ; Johnston, C F ; Hutton, J C ; Buchanan, K D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-452a16a32d490a4e01c75b03bf077f4e00db8b9e38d85532a03c8636988b9643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenal glands</topic><topic>Adrenal Medulla - embryology</topic><topic>Adrenal Medulla - metabolism</topic><topic>Animals</topic><topic>C cells</topic><topic>Central Nervous System - embryology</topic><topic>Central Nervous System - metabolism</topic><topic>CGA gene</topic><topic>Chromaffin cells</topic><topic>Chromogranin A</topic><topic>Chromogranins - metabolism</topic><topic>Digestive System - embryology</topic><topic>Digestive System - metabolism</topic><topic>Embryos</topic><topic>Female</topic><topic>Fetuses</topic><topic>Immune Sera</topic><topic>Immunoreactivity</topic><topic>Immunosorbent Techniques</topic><topic>Intestine</topic><topic>Mucosa</topic><topic>Neonates</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neuroendocrine system</topic><topic>Neurosecretory Systems - embryology</topic><topic>Neurosecretory Systems - metabolism</topic><topic>Ontogeny</topic><topic>Pancreas</topic><topic>Pancreas - embryology</topic><topic>Pancreas - metabolism</topic><topic>Pancreatic Hormones - metabolism</topic><topic>Peptides</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stomach</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - embryology</topic><topic>Thyroid Gland - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barkatullah, S C</creatorcontrib><creatorcontrib>Curry, W J</creatorcontrib><creatorcontrib>Johnston, C F</creatorcontrib><creatorcontrib>Hutton, J C</creatorcontrib><creatorcontrib>Buchanan, K D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Histochemistry and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barkatullah, S C</au><au>Curry, W J</au><au>Johnston, C F</au><au>Hutton, J C</au><au>Buchanan, K D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system</atitle><jtitle>Histochemistry and cell biology</jtitle><addtitle>Histochem Cell Biol</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>107</volume><issue>3</issue><spage>251</spage><epage>257</epage><pages>251-257</pages><issn>0948-6143</issn><eissn>1432-119X</eissn><abstract>The ontogenetic expression of chromogranin A (CgA) and its derived peptides, WE-14 and pancreastatin (PST), was studied in the rat neuroendocrine system employing immunohistochemical analysis of fetal and neonatal specimens from 12.5-day embryos (E12.5), to 42-day postnatal (P42) rats. CgA immunostaining was first detected in endocrine cells of the pancreas, stomach, intestine, adrenal gland and thyroid at E13.5, E14.5, E15.5, E15.5 and E18.5, respectively. PST-like immunoreactivity was detected in endocrine cells of the pancreas at E13.5, stomach, intestine at E15.5, adrenal gland at E17.5 and thyroid at E18.5. WE-14 immunoreactivity was first observed in the immature pancreas at E15.5, mucosal cells of the stomach at E15.5, scattered chromaffin cells in the immature adrenal gland and mucosal cells of the intestine at E17.5 and thyroid parafollicular cells at E18.5. These data confirm that the translation of the CgA gene is regulated differentially in various neuroendocrine tissues and, moreover, suggests that the post-translational processing of the molecule is developmentally controlled.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>9105896</pmid><doi>10.1007/s004180050110</doi><tpages>7</tpages></addata></record> |
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| subjects | Adrenal glands Adrenal Medulla - embryology Adrenal Medulla - metabolism Animals C cells Central Nervous System - embryology Central Nervous System - metabolism CGA gene Chromaffin cells Chromogranin A Chromogranins - metabolism Digestive System - embryology Digestive System - metabolism Embryos Female Fetuses Immune Sera Immunoreactivity Immunosorbent Techniques Intestine Mucosa Neonates Neoplasm Proteins - metabolism Neuroendocrine system Neurosecretory Systems - embryology Neurosecretory Systems - metabolism Ontogeny Pancreas Pancreas - embryology Pancreas - metabolism Pancreatic Hormones - metabolism Peptides Pregnancy Rats Rats, Wistar Stomach Thyroid Thyroid gland Thyroid Gland - embryology Thyroid Gland - metabolism |
| title | Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system |
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