Long‐term follow‐up of proton irradiated malignant melanoma by glucose‐fructose enhanced magnetic resonance imaging
. MR imaging is frequently used to diagnose uveal melanomas due to the characteristic short T2 relaxation time. T2 may be significantly prolonged within 2 h after ingestion of glucose and fructose due to changed water distribution in the melanoma. This method is used to follow melanomas for up to 6...
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| Veröffentlicht in: | Acta ophthalmologica Scandinavica 1997-02, Vol.75 (1), p.17-21 |
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| creator | Thuomas, Karl‐Äke Naeser, Peter |
| description | . MR imaging is frequently used to diagnose uveal melanomas due to the characteristic short T2 relaxation time. T2 may be significantly prolonged within 2 h after ingestion of glucose and fructose due to changed water distribution in the melanoma. This method is used to follow melanomas for up to 6 years after proton beam irradiation. In the tumours, T2 was shortened in parallel in all the lesions during the first 9 months. After this, T2 increased only in tumours which showed recurrence. T2 determination and histopathological examination revealed no signs of recurrence in eyes which were enucleated due to neovasular glaucoma. It is concluded that MR imaging performed with carbohydrate loading, registers metabolic changes induced in the tumour, giving this method great validity in the follow‐up of choroidal malignant melanoma after irradiation. Eighteen patients treated with proton beam for uveal melanoma at the cyclotron in Uppsala, Sweden, were followed. |
| doi_str_mv | 10.1111/j.1600-0420.1997.tb00242.x |
| format | Article |
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MR imaging is frequently used to diagnose uveal melanomas due to the characteristic short T2 relaxation time. T2 may be significantly prolonged within 2 h after ingestion of glucose and fructose due to changed water distribution in the melanoma. This method is used to follow melanomas for up to 6 years after proton beam irradiation. In the tumours, T2 was shortened in parallel in all the lesions during the first 9 months. After this, T2 increased only in tumours which showed recurrence. T2 determination and histopathological examination revealed no signs of recurrence in eyes which were enucleated due to neovasular glaucoma. It is concluded that MR imaging performed with carbohydrate loading, registers metabolic changes induced in the tumour, giving this method great validity in the follow‐up of choroidal malignant melanoma after irradiation. 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MR imaging is frequently used to diagnose uveal melanomas due to the characteristic short T2 relaxation time. T2 may be significantly prolonged within 2 h after ingestion of glucose and fructose due to changed water distribution in the melanoma. This method is used to follow melanomas for up to 6 years after proton beam irradiation. In the tumours, T2 was shortened in parallel in all the lesions during the first 9 months. After this, T2 increased only in tumours which showed recurrence. T2 determination and histopathological examination revealed no signs of recurrence in eyes which were enucleated due to neovasular glaucoma. It is concluded that MR imaging performed with carbohydrate loading, registers metabolic changes induced in the tumour, giving this method great validity in the follow‐up of choroidal malignant melanoma after irradiation. Eighteen patients treated with proton beam for uveal melanoma at the cyclotron in Uppsala, Sweden, were followed.</description><subject>Administration, Oral</subject><subject>carbohydrates</subject><subject>Choroid Neoplasms - diagnosis</subject><subject>Choroid Neoplasms - metabolism</subject><subject>Choroid Neoplasms - radiotherapy</subject><subject>Cyclotrons</subject><subject>eye</subject><subject>Follow-Up Studies</subject><subject>fructose</subject><subject>Fructose - administration & dosage</subject><subject>glucose</subject><subject>Glucose - administration & dosage</subject><subject>Humans</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - radiotherapy</subject><subject>metabolism</subject><subject>Neoplasm Recurrence, Local</subject><subject>proton irradiation</subject><subject>Protons</subject><subject>Radiotherapy, High-Energy - methods</subject><subject>Retrospective Studies</subject><subject>Sweden</subject><subject>Time Factors</subject><issn>1395-3907</issn><issn>1600-0420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUMFO3DAUtCoQUOgnIFkcuGXr2MnG5oCEVtBWWokDcLZs5znNKrEXO9GSG5_Qb-RL6nRX3OvLG8-8eX4ehK5yssjT-b5Z5EtCMlLQRAhRLQZNCC3o4u0LOvuUjhJmosyYINUp-hrjhhAiCKcn6CQVzkRxhqa1d83H-58BQo-t7zq_S7dxi73F2-AH73AbgqpbNUCNe9W1jVNuwD10yvleYT3hphuNj5B8NoxmSBCD-62c-edoHAytwQGidzOH28S1rrlAx1Z1Eb4d6jl6ebh_Xv3M1o8_fq3u1plhS0EzXpWEgQXDSlaYWhTaaAqWlVWpLDWcq0qLShhds1ozDrysleU5M2pJtc0Ldo6u93PTd15HiIPs22igS_uDH6OsuKBVQWlqvNk3muBjDGDlNqRdwyRzIufc5UbO4co5XDnnLg-5y7dkvjy8Muoe6k_rIeik3-71XdvB9B-T5d3jUwLsLwq9mT4</recordid><startdate>199702</startdate><enddate>199702</enddate><creator>Thuomas, Karl‐Äke</creator><creator>Naeser, Peter</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199702</creationdate><title>Long‐term follow‐up of proton irradiated malignant melanoma by glucose‐fructose enhanced magnetic resonance imaging</title><author>Thuomas, Karl‐Äke ; Naeser, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3692-87503efec3534cd94bcb2ef3575af2c88a7b979cbd3db38e85daf813ca62bf143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Oral</topic><topic>carbohydrates</topic><topic>Choroid Neoplasms - diagnosis</topic><topic>Choroid Neoplasms - metabolism</topic><topic>Choroid Neoplasms - radiotherapy</topic><topic>Cyclotrons</topic><topic>eye</topic><topic>Follow-Up Studies</topic><topic>fructose</topic><topic>Fructose - administration & dosage</topic><topic>glucose</topic><topic>Glucose - administration & dosage</topic><topic>Humans</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>melanoma</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - radiotherapy</topic><topic>metabolism</topic><topic>Neoplasm Recurrence, Local</topic><topic>proton irradiation</topic><topic>Protons</topic><topic>Radiotherapy, High-Energy - methods</topic><topic>Retrospective Studies</topic><topic>Sweden</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Thuomas, Karl‐Äke</creatorcontrib><creatorcontrib>Naeser, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thuomas, Karl‐Äke</au><au>Naeser, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term follow‐up of proton irradiated malignant melanoma by glucose‐fructose enhanced magnetic resonance imaging</atitle><jtitle>Acta ophthalmologica Scandinavica</jtitle><addtitle>Acta Ophthalmol Scand</addtitle><date>1997-02</date><risdate>1997</risdate><volume>75</volume><issue>1</issue><spage>17</spage><epage>21</epage><pages>17-21</pages><issn>1395-3907</issn><eissn>1600-0420</eissn><abstract>. MR imaging is frequently used to diagnose uveal melanomas due to the characteristic short T2 relaxation time. T2 may be significantly prolonged within 2 h after ingestion of glucose and fructose due to changed water distribution in the melanoma. This method is used to follow melanomas for up to 6 years after proton beam irradiation. In the tumours, T2 was shortened in parallel in all the lesions during the first 9 months. After this, T2 increased only in tumours which showed recurrence. T2 determination and histopathological examination revealed no signs of recurrence in eyes which were enucleated due to neovasular glaucoma. It is concluded that MR imaging performed with carbohydrate loading, registers metabolic changes induced in the tumour, giving this method great validity in the follow‐up of choroidal malignant melanoma after irradiation. Eighteen patients treated with proton beam for uveal melanoma at the cyclotron in Uppsala, Sweden, were followed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9088394</pmid><doi>10.1111/j.1600-0420.1997.tb00242.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1395-3907 |
| ispartof | Acta ophthalmologica Scandinavica, 1997-02, Vol.75 (1), p.17-21 |
| issn | 1395-3907 1600-0420 |
| language | eng |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Administration, Oral carbohydrates Choroid Neoplasms - diagnosis Choroid Neoplasms - metabolism Choroid Neoplasms - radiotherapy Cyclotrons eye Follow-Up Studies fructose Fructose - administration & dosage glucose Glucose - administration & dosage Humans magnetic resonance imaging Magnetic Resonance Imaging - methods melanoma Melanoma - diagnosis Melanoma - metabolism Melanoma - radiotherapy metabolism Neoplasm Recurrence, Local proton irradiation Protons Radiotherapy, High-Energy - methods Retrospective Studies Sweden Time Factors |
| title | Long‐term follow‐up of proton irradiated malignant melanoma by glucose‐fructose enhanced magnetic resonance imaging |
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