Tetracycline inhibits Porphyromonas gingivalis lipopolysaccharide-induced lesions in vivo and TNFα processing in vitro

Lipopolysaccharides (LPS) are considered one of the more important virulence factors related to the pathogenesis of periodontal diseases. Based on tetracycline (TTC) ability to bind divalent metal ions, the present study was designed to examine the effect of TTC on P. gingivalis LPS‐induced lesions...

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Veröffentlicht in:	Journal of periodontal research 1997-01, Vol.32 (1), p.183-188
Hauptverfasser:	Shapira, L., Houri, Y., Barak, V., Soskolne, W. A., Halabi, A., Stabholz, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents - pharmacology Biological and medical sciences Dentistry Ent. Stomatology Female Humans lipopolysaccharide Lipopolysaccharides - antagonists & inhibitors Medical sciences Mice Mice, Inbred BALB C Monocytes - metabolism periodontal disease-therapy Pharmacology. Drug treatments Porphyromonas gingivalis - chemistry tetracycline Tetracycline - pharmacology TNFα Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis
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