Prolactin (PRL) release-inhibiting properties of the α 2 adrenergic receptor antagonist Idazoxan: Comparison with yohimbine

The effects of the α 2 adrenergic receptor antagonists yohimbine (YOH) and Idazoxan (ID) on secretion of PRL were compared in nonanesthetized male rats bearing permanent intraatrial cannulae for i.v. drug delivery and serial blood sampling. YOH induced a dose-related elevation of basal plasma PRL le...

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Veröffentlicht in:	Life sciences (1973) 1989, Vol.44 (12), p.809-818
Hauptverfasser:	Krulich, Ladislav, Jur̀čovičová, Jana, Le, Thuy
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - pharmacology Adrenergic alpha-Antagonists Animals Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide - pharmacology Clonidine - pharmacology Dioxanes - administration & dosage Dioxanes - pharmacology Dioxins - pharmacology Growth Hormone - metabolism Idazoxan Kinetics Male Morphine - pharmacology Norepinephrine - biosynthesis Prazosin - pharmacology Prolactin - metabolism Quipazine - pharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - physiology Restraint, Physical Space life sciences Yohimbine - administration & dosage Yohimbine - pharmacology
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