The conformation of Ld induced by beta 2-microglobulin is fixed during de novo synthesis and irreversible by exchange or dissociation

Data are presented that support the hypothesis that beta 2m controls the folding of the ligand binding site of newly synthesized class I molecules. This conclusion was indicated by comparisons of two antigenic forms of the Ld molecule separated by sequential immunoprecipitation. Whereas, mAb 30-5-7+...

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Veröffentlicht in:	The Journal of immunology (1950) 1989-04, Vol.142 (8), p.2751-2758
Hauptverfasser:	Myers, NB, Lie, WR, Nett, M, Rubocki, RJ, Hansen, TH
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - metabolism beta 2-Microglobulin - pharmacology Biological Transport Epitopes - analysis Genes, MHC Class I Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Mice Mice, Inbred BALB C Oligosaccharides - metabolism Precipitin Tests Protein Conformation
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