Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse
We established four cell lines, from the liver cells of a transgenic mouse, constructed with hepatitis B virus DNA that had an inverted repeat structure. The integrated DNA patterns of the four established cell lines were different from one another and from the original pattern. These data show that...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1989-02, Vol.37 (2), p.273-278 |
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| container_end_page | 278 |
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| container_issue | 2 |
| container_start_page | 273 |
| container_title | Cancer genetics and cytogenetics |
| container_volume | 37 |
| creator | Hino, Okio Nomura, Kimie Ohtake, Keiko Kawaguchi, Tokuich Sugano, Haruo Kitagawa, Tomoyuki |
| description | We established four cell lines, from the liver cells of a transgenic mouse, constructed with hepatitis B virus DNA that had an inverted repeat structure. The integrated DNA patterns of the four established cell lines were different from one another and from the original pattern. These data show that the instability of integrated hepatitis B virus DNA would also occur in somatic cells during replication, apart from meiosis, which was previously reported. |
| doi_str_mv | 10.1016/0165-4608(89)90059-9 |
| format | Article |
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The integrated DNA patterns of the four established cell lines were different from one another and from the original pattern. These data show that the instability of integrated hepatitis B virus DNA would also occur in somatic cells during replication, apart from meiosis, which was previously reported.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(89)90059-9</identifier><identifier>PMID: 2702627</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biotechnology ; Cell Line ; Chromosome Aberrations ; Chromosome Inversion ; DNA, Viral - analysis ; Fundamental and applied biological sciences. Psychology ; Gene Rearrangement ; Genetic engineering ; Genetic technics ; Hepatitis B virus - genetics ; Methods. Procedures. 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The integrated DNA patterns of the four established cell lines were different from one another and from the original pattern. These data show that the instability of integrated hepatitis B virus DNA would also occur in somatic cells during replication, apart from meiosis, which was previously reported.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cell Line</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Inversion</subject><subject>DNA, Viral - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Rearrangement</subject><subject>Genetic engineering</subject><subject>Genetic technics</subject><subject>Hepatitis B virus - genetics</subject><subject>Methods. Procedures. 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Psychology</topic><topic>Gene Rearrangement</topic><topic>Genetic engineering</topic><topic>Genetic technics</topic><topic>Hepatitis B virus - genetics</topic><topic>Methods. Procedures. 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| fulltext | fulltext |
| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 1989-02, Vol.37 (2), p.273-278 |
| issn | 0165-4608 1873-4456 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78923347 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Biotechnology Cell Line Chromosome Aberrations Chromosome Inversion DNA, Viral - analysis Fundamental and applied biological sciences. Psychology Gene Rearrangement Genetic engineering Genetic technics Hepatitis B virus - genetics Methods. Procedures. Technologies Mice Mice, Transgenic Transgenic animals Transgenic animals and transgenic plants |
| title | Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse |
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