Design and development of pilus vaccines for Haemophilus influenzae diseases
The authors study the roles of pili in adhesion, colonization, virulence and immunity with a focus on their utility as vaccine components. Their concepts and methods of vaccine development have been proved by the continued field success of two pilus vaccines developed in their laboratory: an Escheri...
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| Veröffentlicht in: | The Pediatric infectious disease journal 1989-01, Vol.8 (1 Suppl), p.S54-S61 |
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| container_end_page | S61 |
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| container_issue | 1 Suppl |
| container_start_page | S54 |
| container_title | The Pediatric infectious disease journal |
| container_volume | 8 |
| creator | Brinton, Jr, C C Carter, M J Derber, D B Kar, S Kramarik, J A To, A C To, S C Wood, S W |
| description | The authors study the roles of pili in adhesion, colonization, virulence and immunity with a focus on their utility as vaccine components. Their concepts and methods of vaccine development have been proved by the continued field success of two pilus vaccines developed in their laboratory: an Escherichia coli pilus vaccine for neonatal diarrhea in pigs and a Moraxella bovis pilus vaccine for infectious bovine keratoconjunctivitis (pinkeye) in cattle. These vaccines contain intact pilus rods as the active ingredients. Protection against disease was pilus-specific and, for broad protection, required that the most frequently occurring families and serotypes of pili in the natural population of pathogens be included in the vaccines. |
| doi_str_mv | 10.1097/00006454-198901001-00021 |
| format | Article |
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Their concepts and methods of vaccine development have been proved by the continued field success of two pilus vaccines developed in their laboratory: an Escherichia coli pilus vaccine for neonatal diarrhea in pigs and a Moraxella bovis pilus vaccine for infectious bovine keratoconjunctivitis (pinkeye) in cattle. These vaccines contain intact pilus rods as the active ingredients. 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Their concepts and methods of vaccine development have been proved by the continued field success of two pilus vaccines developed in their laboratory: an Escherichia coli pilus vaccine for neonatal diarrhea in pigs and a Moraxella bovis pilus vaccine for infectious bovine keratoconjunctivitis (pinkeye) in cattle. These vaccines contain intact pilus rods as the active ingredients. 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| identifier | ISSN: 0891-3668 |
| ispartof | The Pediatric infectious disease journal, 1989-01, Vol.8 (1 Suppl), p.S54-S61 |
| issn | 0891-3668 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antibodies, Bacterial - immunology Cross Reactions Fimbriae, Bacterial - immunology Fimbriae, Bacterial - ultrastructure Haemophilus Infections - immunology Haemophilus influenzae Haemophilus influenzae - immunology Haemophilus influenzae - ultrastructure Humans Vaccines - immunology Vaccines, Synthetic - immunology |
| title | Design and development of pilus vaccines for Haemophilus influenzae diseases |
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