Analysis of the feline immune response to human myelin-associated glycoprotein
Elucidation of the pathogenesis of demyelinating peripheral neuropathy associated with myelin-associated glycoprotein (MAG) binding IgM paraproteins requires an in vivo animal model of the syndrome. Multiple immunizations of cats with MAG in Freund's adjuvant did not produce an antibody respons...
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| Veröffentlicht in: | Journal of the neurological sciences 1989-02, Vol.89 (2), p.141-148 |
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| container_end_page | 148 |
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| container_title | Journal of the neurological sciences |
| container_volume | 89 |
| creator | Kahn, Sidney N. Stanton, Nancy L. Sumner, Austin J. Brown, Mark J. Spitalnik, Steven L. Morein, Bror |
| description | Elucidation of the pathogenesis of demyelinating peripheral neuropathy associated with myelin-associated glycoprotein (MAG) binding IgM paraproteins requires an in vivo animal model of the syndrome. Multiple immunizations of cats with MAG in Freund's adjuvant did not produce an antibody response but four immunizations with MAG-iscom (Morein, B. et al. (1984)
Nature, 308: 457–460) did induce IgM antibodies which bound to human MAG and cat peripheral nerve myelin. Despite the presence of antibody for a 13-month period, no neuropathy developed. At necropsy, the peripheral nerves were ultrastructurally normal and no antibody was detectable in the endoneurium. A competitive ELISA indicated that the cat and human IgM antibodies recognized different epitopes. |
| doi_str_mv | 10.1016/0022-510X(89)90015-4 |
| format | Article |
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Nature, 308: 457–460) did induce IgM antibodies which bound to human MAG and cat peripheral nerve myelin. Despite the presence of antibody for a 13-month period, no neuropathy developed. At necropsy, the peripheral nerves were ultrastructurally normal and no antibody was detectable in the endoneurium. A competitive ELISA indicated that the cat and human IgM antibodies recognized different epitopes.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(89)90015-4</identifier><identifier>PMID: 2466957</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Autoantibodies - immunology ; Autoimmune polyneuropathy ; Biological and medical sciences ; Cats ; Demyelinating Diseases - immunology ; Disease Models, Animal ; Feline IgM antibodies ; Humans ; Immunoglobulin mu-Chains - immunology ; Iscom immunization ; Medical sciences ; Myelin Proteins - immunology ; Myelin-Associated Glycoprotein ; Nervous system involvement in other diseases. Miscellaneous ; Neurology</subject><ispartof>Journal of the neurological sciences, 1989-02, Vol.89 (2), p.141-148</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-b9e73066304f1d1b413402196bab322c6ae627e9ef40059fc24b5f4e9d7eba103</citedby><cites>FETCH-LOGICAL-c417t-b9e73066304f1d1b413402196bab322c6ae627e9ef40059fc24b5f4e9d7eba103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(89)90015-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6774643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2466957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahn, Sidney N.</creatorcontrib><creatorcontrib>Stanton, Nancy L.</creatorcontrib><creatorcontrib>Sumner, Austin J.</creatorcontrib><creatorcontrib>Brown, Mark J.</creatorcontrib><creatorcontrib>Spitalnik, Steven L.</creatorcontrib><creatorcontrib>Morein, Bror</creatorcontrib><title>Analysis of the feline immune response to human myelin-associated glycoprotein</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Elucidation of the pathogenesis of demyelinating peripheral neuropathy associated with myelin-associated glycoprotein (MAG) binding IgM paraproteins requires an in vivo animal model of the syndrome. Multiple immunizations of cats with MAG in Freund's adjuvant did not produce an antibody response but four immunizations with MAG-iscom (Morein, B. et al. (1984)
Nature, 308: 457–460) did induce IgM antibodies which bound to human MAG and cat peripheral nerve myelin. Despite the presence of antibody for a 13-month period, no neuropathy developed. At necropsy, the peripheral nerves were ultrastructurally normal and no antibody was detectable in the endoneurium. A competitive ELISA indicated that the cat and human IgM antibodies recognized different epitopes.</description><subject>Animals</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmune polyneuropathy</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Demyelinating Diseases - immunology</subject><subject>Disease Models, Animal</subject><subject>Feline IgM antibodies</subject><subject>Humans</subject><subject>Immunoglobulin mu-Chains - immunology</subject><subject>Iscom immunization</subject><subject>Medical sciences</subject><subject>Myelin Proteins - immunology</subject><subject>Myelin-Associated Glycoprotein</subject><subject>Nervous system involvement in other diseases. 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Miscellaneous</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahn, Sidney N.</creatorcontrib><creatorcontrib>Stanton, Nancy L.</creatorcontrib><creatorcontrib>Sumner, Austin J.</creatorcontrib><creatorcontrib>Brown, Mark J.</creatorcontrib><creatorcontrib>Spitalnik, Steven L.</creatorcontrib><creatorcontrib>Morein, Bror</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kahn, Sidney N.</au><au>Stanton, Nancy L.</au><au>Sumner, Austin J.</au><au>Brown, Mark J.</au><au>Spitalnik, Steven L.</au><au>Morein, Bror</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the feline immune response to human myelin-associated glycoprotein</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>89</volume><issue>2</issue><spage>141</spage><epage>148</epage><pages>141-148</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Elucidation of the pathogenesis of demyelinating peripheral neuropathy associated with myelin-associated glycoprotein (MAG) binding IgM paraproteins requires an in vivo animal model of the syndrome. Multiple immunizations of cats with MAG in Freund's adjuvant did not produce an antibody response but four immunizations with MAG-iscom (Morein, B. et al. (1984)
Nature, 308: 457–460) did induce IgM antibodies which bound to human MAG and cat peripheral nerve myelin. Despite the presence of antibody for a 13-month period, no neuropathy developed. At necropsy, the peripheral nerves were ultrastructurally normal and no antibody was detectable in the endoneurium. A competitive ELISA indicated that the cat and human IgM antibodies recognized different epitopes.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>2466957</pmid><doi>10.1016/0022-510X(89)90015-4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1989-02, Vol.89 (2), p.141-148 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoantibodies - immunology Autoimmune polyneuropathy Biological and medical sciences Cats Demyelinating Diseases - immunology Disease Models, Animal Feline IgM antibodies Humans Immunoglobulin mu-Chains - immunology Iscom immunization Medical sciences Myelin Proteins - immunology Myelin-Associated Glycoprotein Nervous system involvement in other diseases. Miscellaneous Neurology |
| title | Analysis of the feline immune response to human myelin-associated glycoprotein |
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