Significance of AgNOR counts for distinguishing carcinoma from adenoma and hyperplasia in parathyroid gland
Nucleolar organizer region proteins, which can be stained and visualized by an argyrophil technique (AgNORs), are markers of cell activities, such as DNA transcription and proliferation, and they are useful for differential diagnosis between benign and malignant tumors. We counted both AgNOR numbers...
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| Veröffentlicht in: | Human pathology 1997-04, Vol.28 (4), p.421-427 |
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| creator | Kanematsu, Emiko Matsui, Hiroe Deguchi, Takashi Yamamoto, Osami Korematsu, Motoko Kobayashi, Akira Nezasa, Shin-Ichi Yamamoto, Naoki Takeuchi, Toshimi Tanaka, Takuji Kawada, Yukimichi |
| description | Nucleolar organizer region proteins, which can be stained and visualized by an argyrophil technique (AgNORs), are markers of cell activities, such as DNA transcription and proliferation, and they are useful for differential diagnosis between benign and malignant tumors. We counted both AgNOR numbers in 25 parathyroid lesions (three carcinomas, 11 adenomas, 10 hyperplasias, and one hyperplasia with carcinoma) to determine if the AgNOR number could be useful as a diagnostic aid in parathyroid neoplasms and hyperplasias, because it is often difficult to histopathologically distinguish among these lesions. The AgNOR numbers were significantly higher in carcinomas (3.18 ± 0.05) than in adenomas (1.67 ± 0.30,
P < .001) or hyperplasias (1.85 ± 0.16,
P < .001), but there was no significant difference between adenomas and hyperplasias. These results suggest that AgNORs may be useful as an adjunct to discriminating carcinomas from adenomas or hyperplasias in the parathyroid gland. |
| doi_str_mv | 10.1016/S0046-8177(97)90030-7 |
| format | Article |
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P < .001) or hyperplasias (1.85 ± 0.16,
P < .001), but there was no significant difference between adenomas and hyperplasias. These results suggest that AgNORs may be useful as an adjunct to discriminating carcinomas from adenomas or hyperplasias in the parathyroid gland.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(97)90030-7</identifier><identifier>PMID: 9104941</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>adenoma ; Adenoma - metabolism ; Adenoma - pathology ; AgNORs ; Biological and medical sciences ; carcinoma ; Coloring Agents ; Diagnosis, Differential ; Endocrinopathies ; Humans ; hyperplasia ; Hyperplasia - metabolism ; Hyperplasia - pathology ; Malignant tumors ; Medical sciences ; Nucleolus Organizer Region - metabolism ; Parathyroid Diseases - metabolism ; Parathyroid Diseases - pathology ; parathyroid gland ; Parathyroid Neoplasms - metabolism ; Parathyroid Neoplasms - pathology ; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) ; Retrospective Studies ; Silver</subject><ispartof>Human pathology, 1997-04, Vol.28 (4), p.421-427</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c53dcb53ccc04821f2251b259ee8b8bfe0303781932fa0521d870b8d52bd44a3</citedby><cites>FETCH-LOGICAL-c391t-c53dcb53ccc04821f2251b259ee8b8bfe0303781932fa0521d870b8d52bd44a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(97)90030-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2676813$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9104941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanematsu, Emiko</creatorcontrib><creatorcontrib>Matsui, Hiroe</creatorcontrib><creatorcontrib>Deguchi, Takashi</creatorcontrib><creatorcontrib>Yamamoto, Osami</creatorcontrib><creatorcontrib>Korematsu, Motoko</creatorcontrib><creatorcontrib>Kobayashi, Akira</creatorcontrib><creatorcontrib>Nezasa, Shin-Ichi</creatorcontrib><creatorcontrib>Yamamoto, Naoki</creatorcontrib><creatorcontrib>Takeuchi, Toshimi</creatorcontrib><creatorcontrib>Tanaka, Takuji</creatorcontrib><creatorcontrib>Kawada, Yukimichi</creatorcontrib><title>Significance of AgNOR counts for distinguishing carcinoma from adenoma and hyperplasia in parathyroid gland</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Nucleolar organizer region proteins, which can be stained and visualized by an argyrophil technique (AgNORs), are markers of cell activities, such as DNA transcription and proliferation, and they are useful for differential diagnosis between benign and malignant tumors. We counted both AgNOR numbers in 25 parathyroid lesions (three carcinomas, 11 adenomas, 10 hyperplasias, and one hyperplasia with carcinoma) to determine if the AgNOR number could be useful as a diagnostic aid in parathyroid neoplasms and hyperplasias, because it is often difficult to histopathologically distinguish among these lesions. The AgNOR numbers were significantly higher in carcinomas (3.18 ± 0.05) than in adenomas (1.67 ± 0.30,
P < .001) or hyperplasias (1.85 ± 0.16,
P < .001), but there was no significant difference between adenomas and hyperplasias. These results suggest that AgNORs may be useful as an adjunct to discriminating carcinomas from adenomas or hyperplasias in the parathyroid gland.</description><subject>adenoma</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>AgNORs</subject><subject>Biological and medical sciences</subject><subject>carcinoma</subject><subject>Coloring Agents</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>hyperplasia</subject><subject>Hyperplasia - metabolism</subject><subject>Hyperplasia - pathology</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Nucleolus Organizer Region - metabolism</subject><subject>Parathyroid Diseases - metabolism</subject><subject>Parathyroid Diseases - pathology</subject><subject>parathyroid gland</subject><subject>Parathyroid Neoplasms - metabolism</subject><subject>Parathyroid Neoplasms - pathology</subject><subject>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</subject><subject>Retrospective Studies</subject><subject>Silver</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAQgEVpSbdpf0JAh1LagxM9rJV0KiH0EQgJNLkLWY_daW3LlezA_vtqs8teC4JBzDej0TcIXVBySQldXz0S0q4bRaX8rOUXTQgnjXyFVlRw1iiu2Wu0OiFv0btSfhNCqWjFGTrTlLS6pSv05xE2I0RwdnQBp4ivN_cPv7BLyzgXHFPGHsoM42aBsq0BO5sdjGmwOOY0YOvDy8WOHm93U8hTbwtYDCOebLbzdpcTeLzpK_AevYm2L-HDMZ6jp-_fnm5-NncPP25vru8axzWdGye4d53gzjnSKkYjY4J2TOgQVKe6GOpPuVRUcxYtEYx6JUmnvGCdb1vLz9GnQ9spp79LKLMZoLjQ1xFCWoqRSlMtdVtBcQBdTqXkEM2UYbB5Zygxe8fmxbHZCzS6nr1jI2vdxfGBpRuCP1Udpdb8x2PeFmf7mKtbKCeMreVaUV6xrwcsVBfPELIpDkJdg4cc3Gx8gv8M8g_28pl5</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Kanematsu, Emiko</creator><creator>Matsui, Hiroe</creator><creator>Deguchi, Takashi</creator><creator>Yamamoto, Osami</creator><creator>Korematsu, Motoko</creator><creator>Kobayashi, Akira</creator><creator>Nezasa, Shin-Ichi</creator><creator>Yamamoto, Naoki</creator><creator>Takeuchi, Toshimi</creator><creator>Tanaka, Takuji</creator><creator>Kawada, Yukimichi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>Significance of AgNOR counts for distinguishing carcinoma from adenoma and hyperplasia in parathyroid gland</title><author>Kanematsu, Emiko ; Matsui, Hiroe ; Deguchi, Takashi ; Yamamoto, Osami ; Korematsu, Motoko ; Kobayashi, Akira ; Nezasa, Shin-Ichi ; Yamamoto, Naoki ; Takeuchi, Toshimi ; Tanaka, Takuji ; Kawada, Yukimichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c53dcb53ccc04821f2251b259ee8b8bfe0303781932fa0521d870b8d52bd44a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>adenoma</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>AgNORs</topic><topic>Biological and medical sciences</topic><topic>carcinoma</topic><topic>Coloring Agents</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>hyperplasia</topic><topic>Hyperplasia - metabolism</topic><topic>Hyperplasia - pathology</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Nucleolus Organizer Region - metabolism</topic><topic>Parathyroid Diseases - metabolism</topic><topic>Parathyroid Diseases - pathology</topic><topic>parathyroid gland</topic><topic>Parathyroid Neoplasms - metabolism</topic><topic>Parathyroid Neoplasms - pathology</topic><topic>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</topic><topic>Retrospective Studies</topic><topic>Silver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanematsu, Emiko</creatorcontrib><creatorcontrib>Matsui, Hiroe</creatorcontrib><creatorcontrib>Deguchi, Takashi</creatorcontrib><creatorcontrib>Yamamoto, Osami</creatorcontrib><creatorcontrib>Korematsu, Motoko</creatorcontrib><creatorcontrib>Kobayashi, Akira</creatorcontrib><creatorcontrib>Nezasa, Shin-Ichi</creatorcontrib><creatorcontrib>Yamamoto, Naoki</creatorcontrib><creatorcontrib>Takeuchi, Toshimi</creatorcontrib><creatorcontrib>Tanaka, Takuji</creatorcontrib><creatorcontrib>Kawada, Yukimichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanematsu, Emiko</au><au>Matsui, Hiroe</au><au>Deguchi, Takashi</au><au>Yamamoto, Osami</au><au>Korematsu, Motoko</au><au>Kobayashi, Akira</au><au>Nezasa, Shin-Ichi</au><au>Yamamoto, Naoki</au><au>Takeuchi, Toshimi</au><au>Tanaka, Takuji</au><au>Kawada, Yukimichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of AgNOR counts for distinguishing carcinoma from adenoma and hyperplasia in parathyroid gland</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>28</volume><issue>4</issue><spage>421</spage><epage>427</epage><pages>421-427</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Nucleolar organizer region proteins, which can be stained and visualized by an argyrophil technique (AgNORs), are markers of cell activities, such as DNA transcription and proliferation, and they are useful for differential diagnosis between benign and malignant tumors. We counted both AgNOR numbers in 25 parathyroid lesions (three carcinomas, 11 adenomas, 10 hyperplasias, and one hyperplasia with carcinoma) to determine if the AgNOR number could be useful as a diagnostic aid in parathyroid neoplasms and hyperplasias, because it is often difficult to histopathologically distinguish among these lesions. The AgNOR numbers were significantly higher in carcinomas (3.18 ± 0.05) than in adenomas (1.67 ± 0.30,
P < .001) or hyperplasias (1.85 ± 0.16,
P < .001), but there was no significant difference between adenomas and hyperplasias. These results suggest that AgNORs may be useful as an adjunct to discriminating carcinomas from adenomas or hyperplasias in the parathyroid gland.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9104941</pmid><doi>10.1016/S0046-8177(97)90030-7</doi><tpages>7</tpages></addata></record> |
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| subjects | adenoma Adenoma - metabolism Adenoma - pathology AgNORs Biological and medical sciences carcinoma Coloring Agents Diagnosis, Differential Endocrinopathies Humans hyperplasia Hyperplasia - metabolism Hyperplasia - pathology Malignant tumors Medical sciences Nucleolus Organizer Region - metabolism Parathyroid Diseases - metabolism Parathyroid Diseases - pathology parathyroid gland Parathyroid Neoplasms - metabolism Parathyroid Neoplasms - pathology Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Retrospective Studies Silver |
| title | Significance of AgNOR counts for distinguishing carcinoma from adenoma and hyperplasia in parathyroid gland |
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