Determinants of Emergence of Antibiotic-Resistant Neisseria gonorrhoeae
Studies were carried out to evaluate the prevalence and risk factors for antibiotic-resistant Neisseria gonorrhoeae infections. Monthly surveillance of gonococcal isolates showed the prevalence of gonococci with high-level, plasmid-mediated tetracycline resistance (TRNG) to be about 15% for three co...
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| Veröffentlicht in: | The Journal of infectious diseases 1989-05, Vol.159 (5), p.900-907 |
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| creator | Hook, Edward W. Brady, William E. Reicbart, Cindy A. Upchurch, Dawn M. Sherman, Linda A. Wasserheit, Judith N. |
| description | Studies were carried out to evaluate the prevalence and risk factors for antibiotic-resistant Neisseria gonorrhoeae infections. Monthly surveillance of gonococcal isolates showed the prevalence of gonococci with high-level, plasmid-mediated tetracycline resistance (TRNG) to be about 15% for three consecutive 6-mo periods. Over the same period, the prevalence of gonococci with chromosomally mediated resistance to penicillin G steadily increased, from 0% to 9% and then to 21%. From April to July 1987, while chromosomally mediated penicillin resistance was rapidly increasing, a more intensive study was conducted. Patients infected with TRNG reported significantly more lifetime sexual partners (P < .05) but otherwise resembled patients infected with antibiotic-sensitive gonococci. Patients infected with chromosomally mediated penicillin-resistant gonococci differed from other patients. In addition to reporting more lifetime partners (P < .05), patients with chromosomally mediated penicillin-resistant gonorrhea were more likely to be older (P < .05) and more often reported past episodes of gonorrhea (P < .05), greater numbers of recent sexual partners (P < .05), new sexual partners (P < .05), prostitute contact (P = .06), and parenteral drug use or sexual partners who were drug users (P = .07). The introduction of antibiotic-resistant N. gonorrhoeae into communities may be attributable to a subset of patients who practice “risky behaviors” and who could be targeted for disease intervention activities. |
| doi_str_mv | 10.1093/infdis/159.5.900 |
| format | Article |
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Monthly surveillance of gonococcal isolates showed the prevalence of gonococci with high-level, plasmid-mediated tetracycline resistance (TRNG) to be about 15% for three consecutive 6-mo periods. Over the same period, the prevalence of gonococci with chromosomally mediated resistance to penicillin G steadily increased, from 0% to 9% and then to 21%. From April to July 1987, while chromosomally mediated penicillin resistance was rapidly increasing, a more intensive study was conducted. Patients infected with TRNG reported significantly more lifetime sexual partners (P < .05) but otherwise resembled patients infected with antibiotic-sensitive gonococci. Patients infected with chromosomally mediated penicillin-resistant gonococci differed from other patients. In addition to reporting more lifetime partners (P < .05), patients with chromosomally mediated penicillin-resistant gonorrhea were more likely to be older (P < .05) and more often reported past episodes of gonorrhea (P < .05), greater numbers of recent sexual partners (P < .05), new sexual partners (P < .05), prostitute contact (P = .06), and parenteral drug use or sexual partners who were drug users (P = .07). The introduction of antibiotic-resistant N. gonorrhoeae into communities may be attributable to a subset of patients who practice “risky behaviors” and who could be targeted for disease intervention activities.]]></description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/159.5.900</identifier><identifier>PMID: 2496174</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University Chicago Press</publisher><subject>Adolescent ; Adult ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotic resistance ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Drug Resistance, Microbial - genetics ; Female ; Gonorrhea ; Gonorrhea - microbiology ; Humans ; Infections ; Male ; Medical sciences ; Men ; Neisseria gonorrhoeae ; Neisseria gonorrhoeae - drug effects ; Neisseria gonorrhoeae - genetics ; Original Articles ; Penicillin ; Penicillin G - pharmacology ; Penicillin resistance ; Penicillin Resistance - genetics ; Pharmacology. Drug treatments ; Prospective Studies ; R Factors ; Retrospective Studies ; Risk Factors ; Sexually transmitted diseases ; Software ; Surveillance</subject><ispartof>The Journal of infectious diseases, 1989-05, Vol.159 (5), p.900-907</ispartof><rights>Copyright 1989 The University of Chicago</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-3a2801fceb3f385ee8c8c99e83b4b4169c62cc8be53683d115e8cb19c239939a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30136470$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30136470$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6954761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2496174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hook, Edward W.</creatorcontrib><creatorcontrib>Brady, William E.</creatorcontrib><creatorcontrib>Reicbart, Cindy A.</creatorcontrib><creatorcontrib>Upchurch, Dawn M.</creatorcontrib><creatorcontrib>Sherman, Linda A.</creatorcontrib><creatorcontrib>Wasserheit, Judith N.</creatorcontrib><title>Determinants of Emergence of Antibiotic-Resistant Neisseria gonorrhoeae</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description><![CDATA[Studies were carried out to evaluate the prevalence and risk factors for antibiotic-resistant Neisseria gonorrhoeae infections. Monthly surveillance of gonococcal isolates showed the prevalence of gonococci with high-level, plasmid-mediated tetracycline resistance (TRNG) to be about 15% for three consecutive 6-mo periods. Over the same period, the prevalence of gonococci with chromosomally mediated resistance to penicillin G steadily increased, from 0% to 9% and then to 21%. From April to July 1987, while chromosomally mediated penicillin resistance was rapidly increasing, a more intensive study was conducted. Patients infected with TRNG reported significantly more lifetime sexual partners (P < .05) but otherwise resembled patients infected with antibiotic-sensitive gonococci. Patients infected with chromosomally mediated penicillin-resistant gonococci differed from other patients. In addition to reporting more lifetime partners (P < .05), patients with chromosomally mediated penicillin-resistant gonorrhea were more likely to be older (P < .05) and more often reported past episodes of gonorrhea (P < .05), greater numbers of recent sexual partners (P < .05), new sexual partners (P < .05), prostitute contact (P = .06), and parenteral drug use or sexual partners who were drug users (P = .07). The introduction of antibiotic-resistant N. gonorrhoeae into communities may be attributable to a subset of patients who practice “risky behaviors” and who could be targeted for disease intervention activities.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Female</subject><subject>Gonorrhea</subject><subject>Gonorrhea - microbiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Neisseria gonorrhoeae</subject><subject>Neisseria gonorrhoeae - drug effects</subject><subject>Neisseria gonorrhoeae - genetics</subject><subject>Original Articles</subject><subject>Penicillin</subject><subject>Penicillin G - pharmacology</subject><subject>Penicillin resistance</subject><subject>Penicillin Resistance - genetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>R Factors</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sexually transmitted diseases</subject><subject>Software</subject><subject>Surveillance</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EKqFw54KUA-K2qWf9Oceq9IMqgIRaqeJieZ3Z4pJdt_ZGgv8eRwm59jSy3u-9GT0z9h74AjiKkzj2q1hOQOFCLZDzF2wGSphGaxAv2Yzztm3AIr5mb0p54JxLoc0RO2olajByxi4_00R5iKMfpzJP_fx8oHxPY6Dt43ScYhfTFEPzg0osU6Xm3yiWQjn6-X0aU86_Enl6y171fl3o3X4es9uL85uzq2b5_fLL2emyCRLk1AjfWg59oE70wioiG2xAJCs62UnQGHQbgu1ICW3FCkBVogMMrUAU6MUx-7TLfczpaUNlckMsgdZrP1LaFGcsAnLZPguCao3iICrId2DIqZRMvXvMcfD5rwPutiW7XcnVgU65WnK1fNhnb7qBVgfDvtWqf9zrvgS_7rMfQw34j2lU0tQPOsQ8lCnlgyzqVVqa7Zpmp9fi6c9B9_m300YY5a7ufjq5vAN1Ya_dV_EPkKyeow</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>Hook, Edward W.</creator><creator>Brady, William E.</creator><creator>Reicbart, Cindy A.</creator><creator>Upchurch, Dawn M.</creator><creator>Sherman, Linda A.</creator><creator>Wasserheit, Judith N.</creator><general>The University Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19890501</creationdate><title>Determinants of Emergence of Antibiotic-Resistant Neisseria gonorrhoeae</title><author>Hook, Edward W. ; Brady, William E. ; Reicbart, Cindy A. ; Upchurch, Dawn M. ; Sherman, Linda A. ; Wasserheit, Judith N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-3a2801fceb3f385ee8c8c99e83b4b4169c62cc8be53683d115e8cb19c239939a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Female</topic><topic>Gonorrhea</topic><topic>Gonorrhea - microbiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Neisseria gonorrhoeae</topic><topic>Neisseria gonorrhoeae - drug effects</topic><topic>Neisseria gonorrhoeae - genetics</topic><topic>Original Articles</topic><topic>Penicillin</topic><topic>Penicillin G - pharmacology</topic><topic>Penicillin resistance</topic><topic>Penicillin Resistance - genetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>R Factors</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sexually transmitted diseases</topic><topic>Software</topic><topic>Surveillance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hook, Edward W.</creatorcontrib><creatorcontrib>Brady, William E.</creatorcontrib><creatorcontrib>Reicbart, Cindy A.</creatorcontrib><creatorcontrib>Upchurch, Dawn M.</creatorcontrib><creatorcontrib>Sherman, Linda A.</creatorcontrib><creatorcontrib>Wasserheit, Judith N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hook, Edward W.</au><au>Brady, William E.</au><au>Reicbart, Cindy A.</au><au>Upchurch, Dawn M.</au><au>Sherman, Linda A.</au><au>Wasserheit, Judith N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of Emergence of Antibiotic-Resistant Neisseria gonorrhoeae</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1989-05-01</date><risdate>1989</risdate><volume>159</volume><issue>5</issue><spage>900</spage><epage>907</epage><pages>900-907</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract><![CDATA[Studies were carried out to evaluate the prevalence and risk factors for antibiotic-resistant Neisseria gonorrhoeae infections. Monthly surveillance of gonococcal isolates showed the prevalence of gonococci with high-level, plasmid-mediated tetracycline resistance (TRNG) to be about 15% for three consecutive 6-mo periods. Over the same period, the prevalence of gonococci with chromosomally mediated resistance to penicillin G steadily increased, from 0% to 9% and then to 21%. From April to July 1987, while chromosomally mediated penicillin resistance was rapidly increasing, a more intensive study was conducted. Patients infected with TRNG reported significantly more lifetime sexual partners (P < .05) but otherwise resembled patients infected with antibiotic-sensitive gonococci. Patients infected with chromosomally mediated penicillin-resistant gonococci differed from other patients. In addition to reporting more lifetime partners (P < .05), patients with chromosomally mediated penicillin-resistant gonorrhea were more likely to be older (P < .05) and more often reported past episodes of gonorrhea (P < .05), greater numbers of recent sexual partners (P < .05), new sexual partners (P < .05), prostitute contact (P = .06), and parenteral drug use or sexual partners who were drug users (P = .07). The introduction of antibiotic-resistant N. gonorrhoeae into communities may be attributable to a subset of patients who practice “risky behaviors” and who could be targeted for disease intervention activities.]]></abstract><cop>Chicago, IL</cop><pub>The University Chicago Press</pub><pmid>2496174</pmid><doi>10.1093/infdis/159.5.900</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1989-05, Vol.159 (5), p.900-907 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adolescent Adult Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotic resistance Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Drug Resistance, Microbial - genetics Female Gonorrhea Gonorrhea - microbiology Humans Infections Male Medical sciences Men Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Original Articles Penicillin Penicillin G - pharmacology Penicillin resistance Penicillin Resistance - genetics Pharmacology. Drug treatments Prospective Studies R Factors Retrospective Studies Risk Factors Sexually transmitted diseases Software Surveillance |
| title | Determinants of Emergence of Antibiotic-Resistant Neisseria gonorrhoeae |
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