Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: Evidence of diffusion from urine
Following an IV infusion of 2.0 g/m 2 of Etanidazole, the mean tumor concentration 40 min after injection was 126 μg/g in bladder cancer and 65 μg/g in cervical cancer. The tumor/plasma concentration ratio was 1.88 in bladder and 0.85 in cervical cancer. This high tumor concentration in bladder canc...
Gespeichert in:
| Veröffentlicht in: | Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1989-04, Vol.16 (4), p.1083-1084 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1084 |
|---|---|
| container_issue | 4 |
| container_start_page | 1083 |
| container_title | Int. J. Radiat. Oncol., Biol. Phys.; (United States) |
| container_volume | 16 |
| creator | Awwad, Hassan K. El Badawy, Samy Abd El Baki, Hoda Zaghloul, Mohammed Osman, Abd El Moneim Akouh, Hany Fairchild, Karen |
| description | Following an IV infusion of 2.0 g/m
2 of Etanidazole, the mean tumor concentration 40 min after injection was 126 μg/g in bladder cancer and 65 μg/g in cervical cancer. The tumor/plasma concentration ratio was 1.88 in bladder and 0.85 in cervical cancer. This high tumor concentration in bladder cancer could be accounted for by diffusion from a highly concentrated urine. This renders bladder cancer a suitable clinical model for testing this sensitizer. |
| doi_str_mv | 10.1016/0360-3016(89)90921-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_proquest_miscellaneous_78918365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0360301689909218</els_id><sourcerecordid>78918365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-a220c564531ee8eaec3582f5872575b06edb258c1e62ed352fabace0d393062d3</originalsourceid><addsrcrecordid>eNp9kU1LJDEQhsOijKO7_0AheBA9tJuPSXd6D4IMuisILvsB3kI6qWYydidu0j3g_nrTzuDRU71Qb71VPIXQMSWXlNDyK-ElKXhW57K-qEnNaCE_oTmVVV1wIR730PzdcoAOU1oTQiitFjM0Y4Kxmso5Wv9c6dhrE56ch8GZhEOLYdDeWf0_dIDPf_8qmCDyAjuPm05bCxFrb7GBuHFGd9hon_U3fLNxFrKcEqxr2zG54HEbQ4_HmNM_o_1Wdwm-7OoR-nt782f5o7h_-H63vL4vDJeLodCMESPKheAUQIIGw4VkrZAVE5VoSAm2YUIaCiUDywVrdaMNEMtrTkpm-RE63eaGNDiVjBvArEzwHsygSlJXnPBsOtuanmP4N0IaVO-Sga7THsKYVCUzHl6KbFxsjSaGlCK06jm6XscXRYma_qAmyGqCrGSt3v6gZB472eWPTQ_2fWgHPvevtn3IJDYO4nToRM-6ON1pg_t4wSt2YJYA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78918365</pqid></control><display><type>article</type><title>Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: Evidence of diffusion from urine</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Awwad, Hassan K. ; El Badawy, Samy ; Abd El Baki, Hoda ; Zaghloul, Mohammed ; Osman, Abd El Moneim ; Akouh, Hany ; Fairchild, Karen</creator><creatorcontrib>Awwad, Hassan K. ; El Badawy, Samy ; Abd El Baki, Hoda ; Zaghloul, Mohammed ; Osman, Abd El Moneim ; Akouh, Hany ; Fairchild, Karen ; National Cancer Institute, Cairo (Egypt)</creatorcontrib><description>Following an IV infusion of 2.0 g/m
2 of Etanidazole, the mean tumor concentration 40 min after injection was 126 μg/g in bladder cancer and 65 μg/g in cervical cancer. The tumor/plasma concentration ratio was 1.88 in bladder and 0.85 in cervical cancer. This high tumor concentration in bladder cancer could be accounted for by diffusion from a highly concentrated urine. This renders bladder cancer a suitable clinical model for testing this sensitizer.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(89)90921-8</identifier><identifier>PMID: 2522918</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>550603 - Medicine- External Radiation in Therapy- (1980-) ; 560151 - Radiation Effects on Animals- Man ; BLADDER ; Bladder cancer ; BODY ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - urine ; Diffusion ; DISEASES ; DRUGS ; Etanidazole ; EVALUATION ; Female ; FEMALE GENITALS ; Humans ; NEOPLASMS ; Nitroimidazoles - pharmacokinetics ; Nitroimidazoles - urine ; ORGANS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Radiation-Sensitizing Agents - pharmacokinetics ; Radiation-Sensitizing Agents - urine ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOSENSITIZERS ; SR-2508 ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - urine ; URINARY TRACT ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - urine ; UTERUS</subject><ispartof>Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1989-04, Vol.16 (4), p.1083-1084</ispartof><rights>1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-a220c564531ee8eaec3582f5872575b06edb258c1e62ed352fabace0d393062d3</citedby><cites>FETCH-LOGICAL-c384t-a220c564531ee8eaec3582f5872575b06edb258c1e62ed352fabace0d393062d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0360301689909218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2522918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6097303$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Awwad, Hassan K.</creatorcontrib><creatorcontrib>El Badawy, Samy</creatorcontrib><creatorcontrib>Abd El Baki, Hoda</creatorcontrib><creatorcontrib>Zaghloul, Mohammed</creatorcontrib><creatorcontrib>Osman, Abd El Moneim</creatorcontrib><creatorcontrib>Akouh, Hany</creatorcontrib><creatorcontrib>Fairchild, Karen</creatorcontrib><creatorcontrib>National Cancer Institute, Cairo (Egypt)</creatorcontrib><title>Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: Evidence of diffusion from urine</title><title>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Following an IV infusion of 2.0 g/m
2 of Etanidazole, the mean tumor concentration 40 min after injection was 126 μg/g in bladder cancer and 65 μg/g in cervical cancer. The tumor/plasma concentration ratio was 1.88 in bladder and 0.85 in cervical cancer. This high tumor concentration in bladder cancer could be accounted for by diffusion from a highly concentrated urine. This renders bladder cancer a suitable clinical model for testing this sensitizer.</description><subject>550603 - Medicine- External Radiation in Therapy- (1980-)</subject><subject>560151 - Radiation Effects on Animals- Man</subject><subject>BLADDER</subject><subject>Bladder cancer</subject><subject>BODY</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - urine</subject><subject>Diffusion</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>Etanidazole</subject><subject>EVALUATION</subject><subject>Female</subject><subject>FEMALE GENITALS</subject><subject>Humans</subject><subject>NEOPLASMS</subject><subject>Nitroimidazoles - pharmacokinetics</subject><subject>Nitroimidazoles - urine</subject><subject>ORGANS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Radiation-Sensitizing Agents - pharmacokinetics</subject><subject>Radiation-Sensitizing Agents - urine</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOSENSITIZERS</subject><subject>SR-2508</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - urine</subject><subject>URINARY TRACT</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - urine</subject><subject>UTERUS</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LJDEQhsOijKO7_0AheBA9tJuPSXd6D4IMuisILvsB3kI6qWYydidu0j3g_nrTzuDRU71Qb71VPIXQMSWXlNDyK-ElKXhW57K-qEnNaCE_oTmVVV1wIR730PzdcoAOU1oTQiitFjM0Y4Kxmso5Wv9c6dhrE56ch8GZhEOLYdDeWf0_dIDPf_8qmCDyAjuPm05bCxFrb7GBuHFGd9hon_U3fLNxFrKcEqxr2zG54HEbQ4_HmNM_o_1Wdwm-7OoR-nt782f5o7h_-H63vL4vDJeLodCMESPKheAUQIIGw4VkrZAVE5VoSAm2YUIaCiUDywVrdaMNEMtrTkpm-RE63eaGNDiVjBvArEzwHsygSlJXnPBsOtuanmP4N0IaVO-Sga7THsKYVCUzHl6KbFxsjSaGlCK06jm6XscXRYma_qAmyGqCrGSt3v6gZB472eWPTQ_2fWgHPvevtn3IJDYO4nToRM-6ON1pg_t4wSt2YJYA</recordid><startdate>19890401</startdate><enddate>19890401</enddate><creator>Awwad, Hassan K.</creator><creator>El Badawy, Samy</creator><creator>Abd El Baki, Hoda</creator><creator>Zaghloul, Mohammed</creator><creator>Osman, Abd El Moneim</creator><creator>Akouh, Hany</creator><creator>Fairchild, Karen</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19890401</creationdate><title>Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: Evidence of diffusion from urine</title><author>Awwad, Hassan K. ; El Badawy, Samy ; Abd El Baki, Hoda ; Zaghloul, Mohammed ; Osman, Abd El Moneim ; Akouh, Hany ; Fairchild, Karen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-a220c564531ee8eaec3582f5872575b06edb258c1e62ed352fabace0d393062d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550603 - Medicine- External Radiation in Therapy- (1980-)</topic><topic>560151 - Radiation Effects on Animals- Man</topic><topic>BLADDER</topic><topic>Bladder cancer</topic><topic>BODY</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - urine</topic><topic>Diffusion</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>Etanidazole</topic><topic>EVALUATION</topic><topic>Female</topic><topic>FEMALE GENITALS</topic><topic>Humans</topic><topic>NEOPLASMS</topic><topic>Nitroimidazoles - pharmacokinetics</topic><topic>Nitroimidazoles - urine</topic><topic>ORGANS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Radiation-Sensitizing Agents - pharmacokinetics</topic><topic>Radiation-Sensitizing Agents - urine</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOSENSITIZERS</topic><topic>SR-2508</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary Bladder Neoplasms - urine</topic><topic>URINARY TRACT</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - urine</topic><topic>UTERUS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awwad, Hassan K.</creatorcontrib><creatorcontrib>El Badawy, Samy</creatorcontrib><creatorcontrib>Abd El Baki, Hoda</creatorcontrib><creatorcontrib>Zaghloul, Mohammed</creatorcontrib><creatorcontrib>Osman, Abd El Moneim</creatorcontrib><creatorcontrib>Akouh, Hany</creatorcontrib><creatorcontrib>Fairchild, Karen</creatorcontrib><creatorcontrib>National Cancer Institute, Cairo (Egypt)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awwad, Hassan K.</au><au>El Badawy, Samy</au><au>Abd El Baki, Hoda</au><au>Zaghloul, Mohammed</au><au>Osman, Abd El Moneim</au><au>Akouh, Hany</au><au>Fairchild, Karen</au><aucorp>National Cancer Institute, Cairo (Egypt)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: Evidence of diffusion from urine</atitle><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1989-04-01</date><risdate>1989</risdate><volume>16</volume><issue>4</issue><spage>1083</spage><epage>1084</epage><pages>1083-1084</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Following an IV infusion of 2.0 g/m
2 of Etanidazole, the mean tumor concentration 40 min after injection was 126 μg/g in bladder cancer and 65 μg/g in cervical cancer. The tumor/plasma concentration ratio was 1.88 in bladder and 0.85 in cervical cancer. This high tumor concentration in bladder cancer could be accounted for by diffusion from a highly concentrated urine. This renders bladder cancer a suitable clinical model for testing this sensitizer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2522918</pmid><doi>10.1016/0360-3016(89)90921-8</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1989-04, Vol.16 (4), p.1083-1084 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78918365 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 550603 - Medicine- External Radiation in Therapy- (1980-) 560151 - Radiation Effects on Animals- Man BLADDER Bladder cancer BODY Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - urine Diffusion DISEASES DRUGS Etanidazole EVALUATION Female FEMALE GENITALS Humans NEOPLASMS Nitroimidazoles - pharmacokinetics Nitroimidazoles - urine ORGANS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-Sensitizing Agents - pharmacokinetics Radiation-Sensitizing Agents - urine RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIZERS SR-2508 Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - urine URINARY TRACT Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - urine UTERUS |
| title | Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: Evidence of diffusion from urine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T07%3A53%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacokinetics%20of%20etanidazole%20(SR-2508)%20in%20bladder%20and%20cervical%20cancer:%20Evidence%20of%20diffusion%20from%20urine&rft.jtitle=Int.%20J.%20Radiat.%20Oncol.,%20Biol.%20Phys.;%20(United%20States)&rft.au=Awwad,%20Hassan%20K.&rft.aucorp=National%20Cancer%20Institute,%20Cairo%20(Egypt)&rft.date=1989-04-01&rft.volume=16&rft.issue=4&rft.spage=1083&rft.epage=1084&rft.pages=1083-1084&rft.issn=0360-3016&rft.eissn=1879-355X&rft_id=info:doi/10.1016/0360-3016(89)90921-8&rft_dat=%3Cproquest_osti_%3E78918365%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78918365&rft_id=info:pmid/2522918&rft_els_id=0360301689909218&rfr_iscdi=true |