MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes

Positive selection of T cell precursors is an MHC dependent, multistep process by which functionally mature CD4+8- helper and CD4-8+ cytotoxic single positive (SP) T cells are generated from immature CD4+8+ double positive (DP) thymocytes. We investigated the requirement for TCR/MHC class II interac...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-04, Vol.158 (8), p.3730-3737
Hauptverfasser:	Vanhecke, D, Verhasselt, B, De Smedt, M, De Paepe, B, Leclercq, G, Plum, J, Vandekerckhove, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology Cell Differentiation - immunology Child Child, Preschool Flow Cytometry Histocompatibility Antigens Class II - immunology Humans Infant Mice Signal Transduction - immunology Thymus Gland - cytology Thymus Gland - immunology
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