Embryonic heart mesenchymal cell migration in laminin

Laminin, a large glycoprotein and major component of basement membranes, influences cell adhesion, migration, morphology, and differentiation. A peptide sequence, YIGSR, from the B1 chain of laminin has been found to correspond to an active site for cell adhesion. We report here that cardiac mesench...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Developmental biology 1989-05, Vol.133 (1), p.37-43
Hauptverfasser:	Davis, Lynn A., Ogle, Roy C., Little, Charles D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane Biological and medical sciences Cell Adhesion - drug effects Cell Movement - drug effects Chick Embryo Collagen Culture Techniques Embryology: invertebrates and vertebrates. Teratology embryos Experimental organogenesis Fundamental and applied biological sciences. Psychology Heart - embryology Laminin mesenchyme Mesoderm - cytology Myocardium - cytology Oligopeptides - pharmacology Organogenesis. Physiological fonctions
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Laminin, a large glycoprotein and major component of basement membranes, influences cell adhesion, migration, morphology, and differentiation. A peptide sequence, YIGSR, from the B1 chain of laminin has been found to correspond to an active site for cell adhesion. We report here that cardiac mesenchymal cells migrate vigorously within three-dimensional gels of laminin and that the YIGSR peptide will completely abolish this migratory activity. In contrast, migration of the mesenchymal cells into three-dimensional gels composed of collagen or collagen + laminin is not effected by YIGSR or other peptides (GRGDS, GRGDTP) reported to mediate cellular adhesion.
ISSN:	0012-1606 1095-564X
DOI:	10.1016/0012-1606(89)90294-7