Non-insulin dependent diabetes mellitus in Psammomys obesus is independent of changes in tissue fatty acid composition
Recently it has been postulated that membrane fatty acid composition may be involved in the pathogenesis of insulin resistance and non‐insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine whether alterations in tissue phospholipid (PL) fatty acids are present in hyperg...
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| Veröffentlicht in: | Lipids 1997-03, Vol.32 (3), p.317-322 |
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| creator | Collier, G R Collier, F M Sanigorski, A Walder, K Cameron-Smith, D Sinclair, A J |
| description | Recently it has been postulated that membrane fatty acid composition may be involved in the pathogenesis of insulin resistance and non‐insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine whether alterations in tissue phospholipid (PL) fatty acids are present in hyperglycemic and hyperinsulinemic Psammomys obesus. On a native diet of salt bush, P. obesus (Israeli sand rat) remains lean and free of diabetes; however, when placed on a normal laboratory chow, a significant proportion of these animals develops a number of metabolic disorders associated with NIDDM, providing an ideal animal model of obesity and NIDDM. Four groups of mature P. obesus were studied: group A; normoglycemic and normoinsulinemic; group B: normoglycemic and hyperinsulinemic; group C: hyperglycemic and hyperinsulinemic; and group D: hyperglycemic hypoinsulinemic. In liver and red gastrocnemius muscle, there were no significant differences between groups, A, B, and in fatty acid composition of PL. Minor differences in individual fatty acids were demonstrated in group D animals (increased liver 20∶4n‐6 and increased muscle 22∶5n‐3); however, the unsaturation indices in liver and muscle were not significantly different between any of the groups. In considering that the minor changes in group D animals were not demonstrated in hyperinsulinemic group B animals or hyperglycemic, hyperinsulinemic group C animals, it is likely that the differences in group D animals were secondary to the more severe disturbances in glucose homeostasis and hypoinsulinemia present in these animals. The results of this study suggest that in this rodent diabetic model significant disturbances in glucose homeostasis and hyperinsulinemia may develop independently of changes in tissue fatty acid composition. |
| doi_str_mv | 10.1007/s11745-997-0039-7 |
| format | Article |
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(Belgium). Faculteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen</creatorcontrib><description>Recently it has been postulated that membrane fatty acid composition may be involved in the pathogenesis of insulin resistance and non‐insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine whether alterations in tissue phospholipid (PL) fatty acids are present in hyperglycemic and hyperinsulinemic Psammomys obesus. On a native diet of salt bush, P. obesus (Israeli sand rat) remains lean and free of diabetes; however, when placed on a normal laboratory chow, a significant proportion of these animals develops a number of metabolic disorders associated with NIDDM, providing an ideal animal model of obesity and NIDDM. Four groups of mature P. obesus were studied: group A; normoglycemic and normoinsulinemic; group B: normoglycemic and hyperinsulinemic; group C: hyperglycemic and hyperinsulinemic; and group D: hyperglycemic hypoinsulinemic. In liver and red gastrocnemius muscle, there were no significant differences between groups, A, B, and in fatty acid composition of PL. Minor differences in individual fatty acids were demonstrated in group D animals (increased liver 20∶4n‐6 and increased muscle 22∶5n‐3); however, the unsaturation indices in liver and muscle were not significantly different between any of the groups. In considering that the minor changes in group D animals were not demonstrated in hyperinsulinemic group B animals or hyperglycemic, hyperinsulinemic group C animals, it is likely that the differences in group D animals were secondary to the more severe disturbances in glucose homeostasis and hypoinsulinemia present in these animals. The results of this study suggest that in this rodent diabetic model significant disturbances in glucose homeostasis and hyperinsulinemia may develop independently of changes in tissue fatty acid composition.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-997-0039-7</identifier><identifier>PMID: 9076669</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Animal models ; Animals ; Blood Glucose - metabolism ; Body Weight ; diabete ; Diabetes ; Diabetes Mellitus, Type 2 - metabolism ; Disease Models, Animal ; Fatty acids ; Fatty Acids - analysis ; Fatty Acids - chemistry ; Fatty Acids - metabolism ; Gerbillinae ; Homeostasis ; Hyperglycemia - metabolism ; Hyperinsulinism - metabolism ; Insulin - blood ; Insulin - metabolism ; Liver - metabolism ; Male ; Membrane Lipids - chemistry ; Membrane Lipids - metabolism ; Metabolic disorders ; Muscle, Skeletal - metabolism ; Phospholipids - chemistry ; Phospholipids - metabolism ; Rodents</subject><ispartof>Lipids, 1997-03, Vol.32 (3), p.317-322</ispartof><rights>1997 American Oil Chemists' Society (AOCS)</rights><rights>AOCS Press 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4607-67853566b6889c7819b8609f8a92103eca10237b65efa9dd0c3f9d2bcc5d7a843</citedby><cites>FETCH-LOGICAL-c4607-67853566b6889c7819b8609f8a92103eca10237b65efa9dd0c3f9d2bcc5d7a843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-997-0039-7$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-997-0039-7$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9076669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collier, G R</creatorcontrib><creatorcontrib>Collier, F M</creatorcontrib><creatorcontrib>Sanigorski, A</creatorcontrib><creatorcontrib>Walder, K</creatorcontrib><creatorcontrib>Cameron-Smith, D</creatorcontrib><creatorcontrib>Sinclair, A J</creatorcontrib><creatorcontrib>Deakin University, Geelong, Australia</creatorcontrib><creatorcontrib>Gent Univ. (Belgium). Faculteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen</creatorcontrib><title>Non-insulin dependent diabetes mellitus in Psammomys obesus is independent of changes in tissue fatty acid composition</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Recently it has been postulated that membrane fatty acid composition may be involved in the pathogenesis of insulin resistance and non‐insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine whether alterations in tissue phospholipid (PL) fatty acids are present in hyperglycemic and hyperinsulinemic Psammomys obesus. On a native diet of salt bush, P. obesus (Israeli sand rat) remains lean and free of diabetes; however, when placed on a normal laboratory chow, a significant proportion of these animals develops a number of metabolic disorders associated with NIDDM, providing an ideal animal model of obesity and NIDDM. Four groups of mature P. obesus were studied: group A; normoglycemic and normoinsulinemic; group B: normoglycemic and hyperinsulinemic; group C: hyperglycemic and hyperinsulinemic; and group D: hyperglycemic hypoinsulinemic. In liver and red gastrocnemius muscle, there were no significant differences between groups, A, B, and in fatty acid composition of PL. Minor differences in individual fatty acids were demonstrated in group D animals (increased liver 20∶4n‐6 and increased muscle 22∶5n‐3); however, the unsaturation indices in liver and muscle were not significantly different between any of the groups. In considering that the minor changes in group D animals were not demonstrated in hyperinsulinemic group B animals or hyperglycemic, hyperinsulinemic group C animals, it is likely that the differences in group D animals were secondary to the more severe disturbances in glucose homeostasis and hypoinsulinemia present in these animals. The results of this study suggest that in this rodent diabetic model significant disturbances in glucose homeostasis and hyperinsulinemia may develop independently of changes in tissue fatty acid composition.</description><subject>Animal models</subject><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>diabete</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Disease Models, Animal</subject><subject>Fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids - chemistry</subject><subject>Fatty Acids - metabolism</subject><subject>Gerbillinae</subject><subject>Homeostasis</subject><subject>Hyperglycemia - metabolism</subject><subject>Hyperinsulinism - metabolism</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Membrane Lipids - chemistry</subject><subject>Membrane Lipids - metabolism</subject><subject>Metabolic disorders</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Phospholipids - chemistry</subject><subject>Phospholipids - metabolism</subject><subject>Rodents</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1TAQhS0EKreFH8ACFLHoLjCO48csUXlVuoJK0LXlOE5xlcSXTAK6_x6HXIHEhtVo5nznyNZh7BmHVxxAvybOdS1LRF0CCCz1A7bjUpoSBeiHbAdQ1WVdAX_Mzonu88prlGfsDEErpXDHfnxKYxlHWvo4Fm04hLEN41y00TVhDlQMoe_jvFCR5Rtyw5CGIxWpCbTe1vNfU-oK_82Nd-E3PUeiJRSdm-dj4XxsC5-GQ6I4xzQ-YY8611N4epoX7Pb9u69XH8v95w_XV2_2pa8V6FJpI4VUqlHGoNeGY2MUYGccVhxE8I5DJXSjZOgcti140WFbNd7LVjtTiwt2ueUepvR9CTTbIZLPf3JjSAtZbZBLBJnBl_-A92mZxvw2a4zhAhBEhvgG-SkRTaGzhykObjpaDnYtxG6F2FyIXQuxOnuen4KXZgjtH8epgazrTf8Z-3D8f6DdX9-8BcHX5Bebs3PJurspkr39wjMJgCgBxS9GZKDr</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>Collier, G R</creator><creator>Collier, F M</creator><creator>Sanigorski, A</creator><creator>Walder, K</creator><creator>Cameron-Smith, D</creator><creator>Sinclair, A J</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>199703</creationdate><title>Non-insulin dependent diabetes mellitus in Psammomys obesus is independent of changes in tissue fatty acid composition</title><author>Collier, G R ; Collier, F M ; Sanigorski, A ; Walder, K ; Cameron-Smith, D ; Sinclair, A J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4607-67853566b6889c7819b8609f8a92103eca10237b65efa9dd0c3f9d2bcc5d7a843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>diabete</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Disease Models, Animal</topic><topic>Fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids - chemistry</topic><topic>Fatty Acids - metabolism</topic><topic>Gerbillinae</topic><topic>Homeostasis</topic><topic>Hyperglycemia - metabolism</topic><topic>Hyperinsulinism - metabolism</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Membrane Lipids - chemistry</topic><topic>Membrane Lipids - metabolism</topic><topic>Metabolic disorders</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Phospholipids - chemistry</topic><topic>Phospholipids - metabolism</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collier, G R</creatorcontrib><creatorcontrib>Collier, F M</creatorcontrib><creatorcontrib>Sanigorski, A</creatorcontrib><creatorcontrib>Walder, K</creatorcontrib><creatorcontrib>Cameron-Smith, D</creatorcontrib><creatorcontrib>Sinclair, A J</creatorcontrib><creatorcontrib>Deakin University, Geelong, Australia</creatorcontrib><creatorcontrib>Gent Univ. 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(Belgium). Faculteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-insulin dependent diabetes mellitus in Psammomys obesus is independent of changes in tissue fatty acid composition</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1997-03</date><risdate>1997</risdate><volume>32</volume><issue>3</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Recently it has been postulated that membrane fatty acid composition may be involved in the pathogenesis of insulin resistance and non‐insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine whether alterations in tissue phospholipid (PL) fatty acids are present in hyperglycemic and hyperinsulinemic Psammomys obesus. On a native diet of salt bush, P. obesus (Israeli sand rat) remains lean and free of diabetes; however, when placed on a normal laboratory chow, a significant proportion of these animals develops a number of metabolic disorders associated with NIDDM, providing an ideal animal model of obesity and NIDDM. Four groups of mature P. obesus were studied: group A; normoglycemic and normoinsulinemic; group B: normoglycemic and hyperinsulinemic; group C: hyperglycemic and hyperinsulinemic; and group D: hyperglycemic hypoinsulinemic. In liver and red gastrocnemius muscle, there were no significant differences between groups, A, B, and in fatty acid composition of PL. Minor differences in individual fatty acids were demonstrated in group D animals (increased liver 20∶4n‐6 and increased muscle 22∶5n‐3); however, the unsaturation indices in liver and muscle were not significantly different between any of the groups. In considering that the minor changes in group D animals were not demonstrated in hyperinsulinemic group B animals or hyperglycemic, hyperinsulinemic group C animals, it is likely that the differences in group D animals were secondary to the more severe disturbances in glucose homeostasis and hypoinsulinemia present in these animals. The results of this study suggest that in this rodent diabetic model significant disturbances in glucose homeostasis and hyperinsulinemia may develop independently of changes in tissue fatty acid composition.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>9076669</pmid><doi>10.1007/s11745-997-0039-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Lipids, 1997-03, Vol.32 (3), p.317-322 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; SpringerLink Journals - AutoHoldings |
| subjects | Animal models Animals Blood Glucose - metabolism Body Weight diabete Diabetes Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Fatty acids Fatty Acids - analysis Fatty Acids - chemistry Fatty Acids - metabolism Gerbillinae Homeostasis Hyperglycemia - metabolism Hyperinsulinism - metabolism Insulin - blood Insulin - metabolism Liver - metabolism Male Membrane Lipids - chemistry Membrane Lipids - metabolism Metabolic disorders Muscle, Skeletal - metabolism Phospholipids - chemistry Phospholipids - metabolism Rodents |
| title | Non-insulin dependent diabetes mellitus in Psammomys obesus is independent of changes in tissue fatty acid composition |
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