Cardiological effects of catecholamine-secreting tumours
Correlations between endocrine and cardiological findings were investigated in 106 patients with catecholamine‐secreting tumours during the florid phase of their illness. Endocrine data showed an elevation of urinary catecholamine or vanillylmandelic acid excretion in all but one subject. Hypertensi...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical investigation 1997-03, Vol.27 (3), p.189-195 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 195 |
|---|---|
| container_issue | 3 |
| container_start_page | 189 |
| container_title | European journal of clinical investigation |
| container_volume | 27 |
| creator | SCHU¨RMEYER, T. H. ENGEROFF, B. DRALLE, H. VON ZUR MU¨HLEN, A. |
| description | Correlations between endocrine and cardiological findings were investigated in 106 patients with catecholamine‐secreting tumours during the florid phase of their illness. Endocrine data showed an elevation of urinary catecholamine or vanillylmandelic acid excretion in all but one subject. Hypertension was found in 78%, symptoms of coronary heart disease in 26% and arrhythmias in 20% of the patients. Twelve per cent of the patients came to the hospital with heart attacks, 7% with acute left heart failure and 6% with myocardial infarction. At admission electrocardiograph (ECG) analysis showed a sinus rhythm in 98%, tachycardia > 100 min−1 in 14% and bradycardia |
| doi_str_mv | 10.1046/j.1365-2362.1997.850646.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78913462</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78913462</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4325-507e898a7bc8f959977a19a3cc3bf64b004ba977f00cf848c820649247a2ba3a3</originalsourceid><addsrcrecordid>eNqNkEtrGzEUhUVISR23PyHgQshupnqNHtBNcRInxTgEGgLdiDuKlMqd8STSDHH-fWTGeN3VBZ1z7rn6EPpGcEkwF9_XJWGiKigTtCRay1JVWHBRbo_Q5KAcownGhBdUS_oZnaa0xhgrwugJOtFYKVWxCVJziE-ha7rnYKGZOe-d7dOs8zMLvbN_uwbasHFFcja6PmyeZ_3QdkNMX9AnD01yX_dzih6ur37Pb4rl3eJ2_nNZWM5oVVRYOqUVyNoqr6t8qwSigVnLai94jTGvIT96jK1XXFlF80805RJoDQzYFF2Me19i9zq41Js2JOuaBjauG5KRShPGBc1GPRpt7FKKzpuXGFqI74Zgs6Nm1mbHxuzYmB01M1Iz25w925cMdeueDsk9pqyf73VIGZOPsLEhHWw01wuss-3HaHsLjXv__35zNb_NNVNUjPGQerc9xCH-M0IyWZnH1cKsLu9_XdM_l2bBPgAUbpZo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78913462</pqid></control><display><type>article</type><title>Cardiological effects of catecholamine-secreting tumours</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>SCHU¨RMEYER, T. H. ; ENGEROFF, B. ; DRALLE, H. ; VON ZUR MU¨HLEN, A.</creator><creatorcontrib>SCHU¨RMEYER, T. H. ; ENGEROFF, B. ; DRALLE, H. ; VON ZUR MU¨HLEN, A.</creatorcontrib><description>Correlations between endocrine and cardiological findings were investigated in 106 patients with catecholamine‐secreting tumours during the florid phase of their illness. Endocrine data showed an elevation of urinary catecholamine or vanillylmandelic acid excretion in all but one subject. Hypertension was found in 78%, symptoms of coronary heart disease in 26% and arrhythmias in 20% of the patients. Twelve per cent of the patients came to the hospital with heart attacks, 7% with acute left heart failure and 6% with myocardial infarction. At admission electrocardiograph (ECG) analysis showed a sinus rhythm in 98%, tachycardia > 100 min−1 in 14% and bradycardia <60 min−1 in 10%. In 16% of the ECGs cQT was increased, in 17% the ST segment was lowered and in 37% abnormal T waves occurred. Indices of myocardial hypertrophy such as the Sokolow index, the modified Romhilt–Estes score and the Murphy score were raised in 29%, 19% and 38% respectively. In 23 of 51 (45%) patients echocardiography showed left ventricular hypertrophy, in 16% mitral valve insufficiency and in 24% disturbances of contractility. Comparison of cardiac and endocrine parameters confirm in vitro and animal studies indicating that, in particular, the α‐mimetic noradrenaline (NA) has deleterious effects on the cardiovascular system. Urinary NA, but not adrenaline or dopamine, excretion was significantly higher in constantly hypertensive than in normotensive patients and associated with an elevation of the Sokolow index and the Romhilt–Estes score. Both indices and plasma NA were higher in patients with myocardial hypertrophy and we found a significant correlation between the Romhilt–Estes score and NA excretion.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1046/j.1365-2362.1997.850646.x</identifier><identifier>PMID: 9088853</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Animals ; Arrhythmias, Cardiac - etiology ; Biological and medical sciences ; Cardiac failure ; Cardiomyopathies - etiology ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; catecholamines ; Catecholamines - metabolism ; Coronary Disease - etiology ; Dopamine - metabolism ; Echocardiography ; Electrocardiography ; Endocrinopathies ; Epinephrine - metabolism ; Female ; Humans ; hypertension ; Hypertension - etiology ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - etiology ; Neoplasms - complications ; Neoplasms - metabolism ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Norepinephrine - metabolism ; Paraneoplastic Endocrine Syndromes - complications ; phaeochromocytoma ; symptoms</subject><ispartof>European journal of clinical investigation, 1997-03, Vol.27 (3), p.189-195</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4325-507e898a7bc8f959977a19a3cc3bf64b004ba977f00cf848c820649247a2ba3a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2362.1997.850646.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2362.1997.850646.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2623609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9088853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHU¨RMEYER, T. H.</creatorcontrib><creatorcontrib>ENGEROFF, B.</creatorcontrib><creatorcontrib>DRALLE, H.</creatorcontrib><creatorcontrib>VON ZUR MU¨HLEN, A.</creatorcontrib><title>Cardiological effects of catecholamine-secreting tumours</title><title>European journal of clinical investigation</title><addtitle>European Journal of Clinical Investigation</addtitle><description>Correlations between endocrine and cardiological findings were investigated in 106 patients with catecholamine‐secreting tumours during the florid phase of their illness. Endocrine data showed an elevation of urinary catecholamine or vanillylmandelic acid excretion in all but one subject. Hypertension was found in 78%, symptoms of coronary heart disease in 26% and arrhythmias in 20% of the patients. Twelve per cent of the patients came to the hospital with heart attacks, 7% with acute left heart failure and 6% with myocardial infarction. At admission electrocardiograph (ECG) analysis showed a sinus rhythm in 98%, tachycardia > 100 min−1 in 14% and bradycardia <60 min−1 in 10%. In 16% of the ECGs cQT was increased, in 17% the ST segment was lowered and in 37% abnormal T waves occurred. Indices of myocardial hypertrophy such as the Sokolow index, the modified Romhilt–Estes score and the Murphy score were raised in 29%, 19% and 38% respectively. In 23 of 51 (45%) patients echocardiography showed left ventricular hypertrophy, in 16% mitral valve insufficiency and in 24% disturbances of contractility. Comparison of cardiac and endocrine parameters confirm in vitro and animal studies indicating that, in particular, the α‐mimetic noradrenaline (NA) has deleterious effects on the cardiovascular system. Urinary NA, but not adrenaline or dopamine, excretion was significantly higher in constantly hypertensive than in normotensive patients and associated with an elevation of the Sokolow index and the Romhilt–Estes score. Both indices and plasma NA were higher in patients with myocardial hypertrophy and we found a significant correlation between the Romhilt–Estes score and NA excretion.</description><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac failure</subject><subject>Cardiomyopathies - etiology</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>catecholamines</subject><subject>Catecholamines - metabolism</subject><subject>Coronary Disease - etiology</subject><subject>Dopamine - metabolism</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Endocrinopathies</subject><subject>Epinephrine - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - etiology</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - metabolism</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Norepinephrine - metabolism</subject><subject>Paraneoplastic Endocrine Syndromes - complications</subject><subject>phaeochromocytoma</subject><subject>symptoms</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtrGzEUhUVISR23PyHgQshupnqNHtBNcRInxTgEGgLdiDuKlMqd8STSDHH-fWTGeN3VBZ1z7rn6EPpGcEkwF9_XJWGiKigTtCRay1JVWHBRbo_Q5KAcownGhBdUS_oZnaa0xhgrwugJOtFYKVWxCVJziE-ha7rnYKGZOe-d7dOs8zMLvbN_uwbasHFFcja6PmyeZ_3QdkNMX9AnD01yX_dzih6ur37Pb4rl3eJ2_nNZWM5oVVRYOqUVyNoqr6t8qwSigVnLai94jTGvIT96jK1XXFlF80805RJoDQzYFF2Me19i9zq41Js2JOuaBjauG5KRShPGBc1GPRpt7FKKzpuXGFqI74Zgs6Nm1mbHxuzYmB01M1Iz25w925cMdeueDsk9pqyf73VIGZOPsLEhHWw01wuss-3HaHsLjXv__35zNb_NNVNUjPGQerc9xCH-M0IyWZnH1cKsLu9_XdM_l2bBPgAUbpZo</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>SCHU¨RMEYER, T. H.</creator><creator>ENGEROFF, B.</creator><creator>DRALLE, H.</creator><creator>VON ZUR MU¨HLEN, A.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199703</creationdate><title>Cardiological effects of catecholamine-secreting tumours</title><author>SCHU¨RMEYER, T. H. ; ENGEROFF, B. ; DRALLE, H. ; VON ZUR MU¨HLEN, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4325-507e898a7bc8f959977a19a3cc3bf64b004ba977f00cf848c820649247a2ba3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Animals</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Biological and medical sciences</topic><topic>Cardiac failure</topic><topic>Cardiomyopathies - etiology</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>catecholamines</topic><topic>Catecholamines - metabolism</topic><topic>Coronary Disease - etiology</topic><topic>Dopamine - metabolism</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Endocrinopathies</topic><topic>Epinephrine - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - etiology</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - metabolism</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Norepinephrine - metabolism</topic><topic>Paraneoplastic Endocrine Syndromes - complications</topic><topic>phaeochromocytoma</topic><topic>symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHU¨RMEYER, T. H.</creatorcontrib><creatorcontrib>ENGEROFF, B.</creatorcontrib><creatorcontrib>DRALLE, H.</creatorcontrib><creatorcontrib>VON ZUR MU¨HLEN, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHU¨RMEYER, T. H.</au><au>ENGEROFF, B.</au><au>DRALLE, H.</au><au>VON ZUR MU¨HLEN, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiological effects of catecholamine-secreting tumours</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>European Journal of Clinical Investigation</addtitle><date>1997-03</date><risdate>1997</risdate><volume>27</volume><issue>3</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Correlations between endocrine and cardiological findings were investigated in 106 patients with catecholamine‐secreting tumours during the florid phase of their illness. Endocrine data showed an elevation of urinary catecholamine or vanillylmandelic acid excretion in all but one subject. Hypertension was found in 78%, symptoms of coronary heart disease in 26% and arrhythmias in 20% of the patients. Twelve per cent of the patients came to the hospital with heart attacks, 7% with acute left heart failure and 6% with myocardial infarction. At admission electrocardiograph (ECG) analysis showed a sinus rhythm in 98%, tachycardia > 100 min−1 in 14% and bradycardia <60 min−1 in 10%. In 16% of the ECGs cQT was increased, in 17% the ST segment was lowered and in 37% abnormal T waves occurred. Indices of myocardial hypertrophy such as the Sokolow index, the modified Romhilt–Estes score and the Murphy score were raised in 29%, 19% and 38% respectively. In 23 of 51 (45%) patients echocardiography showed left ventricular hypertrophy, in 16% mitral valve insufficiency and in 24% disturbances of contractility. Comparison of cardiac and endocrine parameters confirm in vitro and animal studies indicating that, in particular, the α‐mimetic noradrenaline (NA) has deleterious effects on the cardiovascular system. Urinary NA, but not adrenaline or dopamine, excretion was significantly higher in constantly hypertensive than in normotensive patients and associated with an elevation of the Sokolow index and the Romhilt–Estes score. Both indices and plasma NA were higher in patients with myocardial hypertrophy and we found a significant correlation between the Romhilt–Estes score and NA excretion.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>9088853</pmid><doi>10.1046/j.1365-2362.1997.850646.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2972 |
| ispartof | European journal of clinical investigation, 1997-03, Vol.27 (3), p.189-195 |
| issn | 0014-2972 1365-2362 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78913462 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Animals Arrhythmias, Cardiac - etiology Biological and medical sciences Cardiac failure Cardiomyopathies - etiology Cardiovascular Diseases - diagnosis Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology catecholamines Catecholamines - metabolism Coronary Disease - etiology Dopamine - metabolism Echocardiography Electrocardiography Endocrinopathies Epinephrine - metabolism Female Humans hypertension Hypertension - etiology Male Medical sciences Middle Aged Myocardial Infarction - etiology Neoplasms - complications Neoplasms - metabolism Non tumoral diseases. Target tissue resistance. Benign neoplasms Norepinephrine - metabolism Paraneoplastic Endocrine Syndromes - complications phaeochromocytoma symptoms |
| title | Cardiological effects of catecholamine-secreting tumours |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T20%3A04%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiological%20effects%20of%20catecholamine-secreting%20tumours&rft.jtitle=European%20journal%20of%20clinical%20investigation&rft.au=SCHU%C2%A8RMEYER,%20T.%20H.&rft.date=1997-03&rft.volume=27&rft.issue=3&rft.spage=189&rft.epage=195&rft.pages=189-195&rft.issn=0014-2972&rft.eissn=1365-2362&rft_id=info:doi/10.1046/j.1365-2362.1997.850646.x&rft_dat=%3Cproquest_cross%3E78913462%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78913462&rft_id=info:pmid/9088853&rfr_iscdi=true |