Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body
Distribution of somatostatin receptors (SSTR1–5) was determined in the rat eye. Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that SSTR4 and SSTR2 are major subtypes expressed predominantly in the iris/ciliary body and retina, respectively, and that SSTR1, SSTR3 and SSTR...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 1997-02, Vol.223 (3), p.185-188 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 188 |
|---|---|
| container_issue | 3 |
| container_start_page | 185 |
| container_title | Neuroscience letters |
| container_volume | 223 |
| creator | Mori, Mikiro Aihara, Makoto Shimizu, Takao |
| description | Distribution of somatostatin receptors (SSTR1–5) was determined in the rat eye. Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that SSTR4 and SSTR2 are major subtypes expressed predominantly in the iris/ciliary body and retina, respectively, and that SSTR1, SSTR3 and SSTR5 are minor subtypes expressed preferentially in the posterior eye segments including the retina. In situ hybridization showed predominant SSTR4 expression in the posterior iris epithelium and ciliary body, suggesting functional roles of somatostatin in the autonomic nervous system in the anterior segments of the eye. The differential expression of SSTR1–5 may be related to distinct roles of somatostatin in the physiology of different ocular tissues. |
| doi_str_mv | 10.1016/S0304-3940(97)13438-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78912530</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304394097134383</els_id><sourcerecordid>78912530</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-87ceeb42fd813fe567aa78075b086a589cfc340e08cb2b4edc7e57490f0ff13a3</originalsourceid><addsrcrecordid>eNqFkE1vEzEQhi0EKqHwEyr5gBA9LB2vvbHNBaHyKVVCIuVseb1jYbRZB49TyL9n06S5chqN3mc-9DB2IeCNALG8WoEE1Uir4LXVl0IqaRr5iC2E0W2jrW4fs8UJecqeEf0CgE506oydWTCglnLB_nxIMWLBqSY_cvy7KUiU8sRz5JTXvmaqvqaJFwy4qbkQn5v6E3nxleMO3_LV6va74mkfVJwIx93DHhwe4FQSXYU0Jl92vM_D7jl7Ev1I-OJYz9mPTx9vr780N98-f71-f9MEaWxtjA6IvWrjYISM2C2199qA7nowS98ZG2KQChBM6Nte4RA0dlpZiBCjkF6es1eHvZuSf2-RqlsnCjiOfsK8JaeNFW0nYQa7AxhKJioY3aak9fyuE-D2wt29cLe36ax298KdnOcujge2_RqH09TR8Jy_POaegh9j8VNIdMLaJQjR2hl7d8BwlnGXsDgKCaeAQ5rNVzfk9J9H_gHMVp63</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78912530</pqid></control><display><type>article</type><title>Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mori, Mikiro ; Aihara, Makoto ; Shimizu, Takao</creator><creatorcontrib>Mori, Mikiro ; Aihara, Makoto ; Shimizu, Takao</creatorcontrib><description>Distribution of somatostatin receptors (SSTR1–5) was determined in the rat eye. Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that SSTR4 and SSTR2 are major subtypes expressed predominantly in the iris/ciliary body and retina, respectively, and that SSTR1, SSTR3 and SSTR5 are minor subtypes expressed preferentially in the posterior eye segments including the retina. In situ hybridization showed predominant SSTR4 expression in the posterior iris epithelium and ciliary body, suggesting functional roles of somatostatin in the autonomic nervous system in the anterior segments of the eye. The differential expression of SSTR1–5 may be related to distinct roles of somatostatin in the physiology of different ocular tissues.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(97)13438-3</identifier><identifier>PMID: 9080463</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Ciliary body ; Ciliary Body - metabolism ; Eye - metabolism ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; In Situ Hybridization ; Iris ; Iris - metabolism ; Male ; Polymerase Chain Reaction ; Rats ; Rats, Sprague-Dawley ; Receptors, Somatostatin - metabolism ; Retina ; Retina - metabolism ; Reverse transcriptase-polymerase chain reaction ; Somatostatin receptor ; Transcription, Genetic ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1997-02, Vol.223 (3), p.185-188</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-87ceeb42fd813fe567aa78075b086a589cfc340e08cb2b4edc7e57490f0ff13a3</citedby><cites>FETCH-LOGICAL-c389t-87ceeb42fd813fe567aa78075b086a589cfc340e08cb2b4edc7e57490f0ff13a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394097134383$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2601129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9080463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Mikiro</creatorcontrib><creatorcontrib>Aihara, Makoto</creatorcontrib><creatorcontrib>Shimizu, Takao</creatorcontrib><title>Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Distribution of somatostatin receptors (SSTR1–5) was determined in the rat eye. Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that SSTR4 and SSTR2 are major subtypes expressed predominantly in the iris/ciliary body and retina, respectively, and that SSTR1, SSTR3 and SSTR5 are minor subtypes expressed preferentially in the posterior eye segments including the retina. In situ hybridization showed predominant SSTR4 expression in the posterior iris epithelium and ciliary body, suggesting functional roles of somatostatin in the autonomic nervous system in the anterior segments of the eye. The differential expression of SSTR1–5 may be related to distinct roles of somatostatin in the physiology of different ocular tissues.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ciliary body</subject><subject>Ciliary Body - metabolism</subject><subject>Eye - metabolism</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Situ Hybridization</subject><subject>Iris</subject><subject>Iris - metabolism</subject><subject>Male</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Somatostatin - metabolism</subject><subject>Retina</subject><subject>Retina - metabolism</subject><subject>Reverse transcriptase-polymerase chain reaction</subject><subject>Somatostatin receptor</subject><subject>Transcription, Genetic</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vEzEQhi0EKqHwEyr5gBA9LB2vvbHNBaHyKVVCIuVseb1jYbRZB49TyL9n06S5chqN3mc-9DB2IeCNALG8WoEE1Uir4LXVl0IqaRr5iC2E0W2jrW4fs8UJecqeEf0CgE506oydWTCglnLB_nxIMWLBqSY_cvy7KUiU8sRz5JTXvmaqvqaJFwy4qbkQn5v6E3nxleMO3_LV6va74mkfVJwIx93DHhwe4FQSXYU0Jl92vM_D7jl7Ev1I-OJYz9mPTx9vr780N98-f71-f9MEaWxtjA6IvWrjYISM2C2199qA7nowS98ZG2KQChBM6Nte4RA0dlpZiBCjkF6es1eHvZuSf2-RqlsnCjiOfsK8JaeNFW0nYQa7AxhKJioY3aak9fyuE-D2wt29cLe36ax298KdnOcujge2_RqH09TR8Jy_POaegh9j8VNIdMLaJQjR2hl7d8BwlnGXsDgKCaeAQ5rNVzfk9J9H_gHMVp63</recordid><startdate>19970228</startdate><enddate>19970228</enddate><creator>Mori, Mikiro</creator><creator>Aihara, Makoto</creator><creator>Shimizu, Takao</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970228</creationdate><title>Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body</title><author>Mori, Mikiro ; Aihara, Makoto ; Shimizu, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-87ceeb42fd813fe567aa78075b086a589cfc340e08cb2b4edc7e57490f0ff13a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Ciliary body</topic><topic>Ciliary Body - metabolism</topic><topic>Eye - metabolism</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Situ Hybridization</topic><topic>Iris</topic><topic>Iris - metabolism</topic><topic>Male</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Somatostatin - metabolism</topic><topic>Retina</topic><topic>Retina - metabolism</topic><topic>Reverse transcriptase-polymerase chain reaction</topic><topic>Somatostatin receptor</topic><topic>Transcription, Genetic</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Mikiro</creatorcontrib><creatorcontrib>Aihara, Makoto</creatorcontrib><creatorcontrib>Shimizu, Takao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Mikiro</au><au>Aihara, Makoto</au><au>Shimizu, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1997-02-28</date><risdate>1997</risdate><volume>223</volume><issue>3</issue><spage>185</spage><epage>188</epage><pages>185-188</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Distribution of somatostatin receptors (SSTR1–5) was determined in the rat eye. Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that SSTR4 and SSTR2 are major subtypes expressed predominantly in the iris/ciliary body and retina, respectively, and that SSTR1, SSTR3 and SSTR5 are minor subtypes expressed preferentially in the posterior eye segments including the retina. In situ hybridization showed predominant SSTR4 expression in the posterior iris epithelium and ciliary body, suggesting functional roles of somatostatin in the autonomic nervous system in the anterior segments of the eye. The differential expression of SSTR1–5 may be related to distinct roles of somatostatin in the physiology of different ocular tissues.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9080463</pmid><doi>10.1016/S0304-3940(97)13438-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1997-02, Vol.223 (3), p.185-188 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78912530 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Ciliary body Ciliary Body - metabolism Eye - metabolism Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology In Situ Hybridization Iris Iris - metabolism Male Polymerase Chain Reaction Rats Rats, Sprague-Dawley Receptors, Somatostatin - metabolism Retina Retina - metabolism Reverse transcriptase-polymerase chain reaction Somatostatin receptor Transcription, Genetic Vertebrates: nervous system and sense organs |
| title | Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T16%3A16%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20expression%20of%20somatostatin%20receptors%20in%20the%20rat%20eye:%20SSTR4%20is%20intensely%20expressed%20in%20the%20iris/ciliary%20body&rft.jtitle=Neuroscience%20letters&rft.au=Mori,%20Mikiro&rft.date=1997-02-28&rft.volume=223&rft.issue=3&rft.spage=185&rft.epage=188&rft.pages=185-188&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/S0304-3940(97)13438-3&rft_dat=%3Cproquest_cross%3E78912530%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78912530&rft_id=info:pmid/9080463&rft_els_id=S0304394097134383&rfr_iscdi=true |