Phosphorylation of neurofilament proteins and localization of axonal swellings in motor neuron disease

Seven lumbosacral spinal cords with motor neuron disease were examined immunocytochemically with monoclonal antibodies (MAb) directed against neurofilament proteins (NFP). Each of the 5 MAbs used in this study was monospecific to one of the triplet of NFP. Two of them were specific to the highly pho...

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Veröffentlicht in:	Journal of the neurological sciences 1989-02, Vol.89 (2), p.269-277
Hauptverfasser:	Toyoshima, Itaru, Yamamoto, Akio, Masamune, Osamu, Satake, Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Antibodies, Monoclonal Axonal swellings Axonal transport Axons - pathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Intermediate Filament Proteins - metabolism Male Medical sciences Middle Aged Motor neuron disease Neurofilament Proteins Neurology Neuromuscular Diseases - metabolism Neuromuscular Diseases - pathology Phosphorylation
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