Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca
The authors evaluated the efficacy of all-trans retinoic acid (vitamin A) ointment as a treatment for keratoconjunctivitis sicca (KCS) in a group of 11 patients selected on the basis of clinical history, slit-lamp examination results, rose Bengal staining, and tear film osmolarity. In this open-labe...
Gespeichert in:
| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 1989-02, Vol.96 (2), p.244-246 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 246 |
|---|---|
| container_issue | 2 |
| container_start_page | 244 |
| container_title | Ophthalmology (Rochester, Minn.) |
| container_volume | 96 |
| creator | Gilbard, Jeffrey P. Huang, Andrew J.W. Belldegrun, Rebecka Lee, Julie S. Rossi, Scott R. Gray, Kathleen L. |
| description | The authors evaluated the efficacy of all-trans retinoic acid (vitamin A) ointment as a treatment for keratoconjunctivitis sicca (KCS) in a group of 11 patients selected on the basis of clinical history, slit-lamp examination results, rose Bengal staining, and tear film osmolarity. In this open-label crossover study, vitamin A ointment was no more effective than placebo in increasing tear secretion, as indicated by Schirmer test with proparacaine or tear film osmolarity, or in decreasing ocular surface disease, as indicated by rose Bengal staining. Seven patients stated some pReference for the placebo ointment, two patients for the vitamin A ointment, and two patients had no pReference. |
| doi_str_mv | 10.1016/S0161-6420(89)32909-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78912085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0161642089329095</els_id><sourcerecordid>78912085</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-1a73f8034ceee66c2e5096cb7fb0cd31770d2f9d8a31632c47484b2bf6820f1d3</originalsourceid><addsrcrecordid>eNqFkEtrGzEQgEVpSd2kPyGgQyntYVu9Vo9TCaaPkIAPTnqs0GpHoLCrdSWtIf--69j42suIYb7RzHwIXVPyhRIqv26XQBspGPmkzWfODDFN-wqtaCtMIxTlr9HqjLxF70p5IoRIycUFumCKiFbwFfqz2UFqBtfBgNd5KmXaQ8bbOvfPeAr4d6xujAnf4E1MdYRUsSvY4YcM7piGKeM7yK5OfkpPc_I17mONBW-j9-4KvQluKPD-9F6ixx_fH9a_mvvNz9v1zX3juTa1oU7xoAkXHgCk9AxaYqTvVOiI7zlVivQsmF47TiVnXiihRce6IDUjgfb8En08_rvL098ZSrVjLB6GwSWY5mKVNpQR3S5gewT94dgMwe5yHF1-tpTYg1f74tUepFlt7ItXe-i7Pg2YuxH6c9dJ5FL_cKq74t0Qsks-ljOmKJWL-gX7dsRgkbGPkG3xEZKHPmbw1fZT_M8i_wCyhJRn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78912085</pqid></control><display><type>article</type><title>Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Gilbard, Jeffrey P. ; Huang, Andrew J.W. ; Belldegrun, Rebecka ; Lee, Julie S. ; Rossi, Scott R. ; Gray, Kathleen L.</creator><creatorcontrib>Gilbard, Jeffrey P. ; Huang, Andrew J.W. ; Belldegrun, Rebecka ; Lee, Julie S. ; Rossi, Scott R. ; Gray, Kathleen L.</creatorcontrib><description>The authors evaluated the efficacy of all-trans retinoic acid (vitamin A) ointment as a treatment for keratoconjunctivitis sicca (KCS) in a group of 11 patients selected on the basis of clinical history, slit-lamp examination results, rose Bengal staining, and tear film osmolarity. In this open-label crossover study, vitamin A ointment was no more effective than placebo in increasing tear secretion, as indicated by Schirmer test with proparacaine or tear film osmolarity, or in decreasing ocular surface disease, as indicated by rose Bengal staining. Seven patients stated some pReference for the placebo ointment, two patients for the vitamin A ointment, and two patients had no pReference.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(89)32909-5</identifier><identifier>PMID: 2704543</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Eye ; Female ; Humans ; Keratoconjunctivitis - drug therapy ; Keratoconjunctivitis Sicca - drug therapy ; Medical sciences ; Middle Aged ; Ointments ; Osmolar Concentration ; Pharmacology. Drug treatments ; Tears - analysis ; Tears - metabolism ; Vitamin A - administration & dosage ; Vitamin A - therapeutic use</subject><ispartof>Ophthalmology (Rochester, Minn.), 1989-02, Vol.96 (2), p.244-246</ispartof><rights>1989 American Academy of Ophthalmology, Inc</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-1a73f8034ceee66c2e5096cb7fb0cd31770d2f9d8a31632c47484b2bf6820f1d3</citedby><cites>FETCH-LOGICAL-c389t-1a73f8034ceee66c2e5096cb7fb0cd31770d2f9d8a31632c47484b2bf6820f1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0161-6420(89)32909-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7116663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2704543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilbard, Jeffrey P.</creatorcontrib><creatorcontrib>Huang, Andrew J.W.</creatorcontrib><creatorcontrib>Belldegrun, Rebecka</creatorcontrib><creatorcontrib>Lee, Julie S.</creatorcontrib><creatorcontrib>Rossi, Scott R.</creatorcontrib><creatorcontrib>Gray, Kathleen L.</creatorcontrib><title>Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>The authors evaluated the efficacy of all-trans retinoic acid (vitamin A) ointment as a treatment for keratoconjunctivitis sicca (KCS) in a group of 11 patients selected on the basis of clinical history, slit-lamp examination results, rose Bengal staining, and tear film osmolarity. In this open-label crossover study, vitamin A ointment was no more effective than placebo in increasing tear secretion, as indicated by Schirmer test with proparacaine or tear film osmolarity, or in decreasing ocular surface disease, as indicated by rose Bengal staining. Seven patients stated some pReference for the placebo ointment, two patients for the vitamin A ointment, and two patients had no pReference.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Eye</subject><subject>Female</subject><subject>Humans</subject><subject>Keratoconjunctivitis - drug therapy</subject><subject>Keratoconjunctivitis Sicca - drug therapy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ointments</subject><subject>Osmolar Concentration</subject><subject>Pharmacology. Drug treatments</subject><subject>Tears - analysis</subject><subject>Tears - metabolism</subject><subject>Vitamin A - administration & dosage</subject><subject>Vitamin A - therapeutic use</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrGzEQgEVpSd2kPyGgQyntYVu9Vo9TCaaPkIAPTnqs0GpHoLCrdSWtIf--69j42suIYb7RzHwIXVPyhRIqv26XQBspGPmkzWfODDFN-wqtaCtMIxTlr9HqjLxF70p5IoRIycUFumCKiFbwFfqz2UFqBtfBgNd5KmXaQ8bbOvfPeAr4d6xujAnf4E1MdYRUsSvY4YcM7piGKeM7yK5OfkpPc_I17mONBW-j9-4KvQluKPD-9F6ixx_fH9a_mvvNz9v1zX3juTa1oU7xoAkXHgCk9AxaYqTvVOiI7zlVivQsmF47TiVnXiihRce6IDUjgfb8En08_rvL098ZSrVjLB6GwSWY5mKVNpQR3S5gewT94dgMwe5yHF1-tpTYg1f74tUepFlt7ItXe-i7Pg2YuxH6c9dJ5FL_cKq74t0Qsks-ljOmKJWL-gX7dsRgkbGPkG3xEZKHPmbw1fZT_M8i_wCyhJRn</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>Gilbard, Jeffrey P.</creator><creator>Huang, Andrew J.W.</creator><creator>Belldegrun, Rebecka</creator><creator>Lee, Julie S.</creator><creator>Rossi, Scott R.</creator><creator>Gray, Kathleen L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890201</creationdate><title>Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca</title><author>Gilbard, Jeffrey P. ; Huang, Andrew J.W. ; Belldegrun, Rebecka ; Lee, Julie S. ; Rossi, Scott R. ; Gray, Kathleen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-1a73f8034ceee66c2e5096cb7fb0cd31770d2f9d8a31632c47484b2bf6820f1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Eye</topic><topic>Female</topic><topic>Humans</topic><topic>Keratoconjunctivitis - drug therapy</topic><topic>Keratoconjunctivitis Sicca - drug therapy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ointments</topic><topic>Osmolar Concentration</topic><topic>Pharmacology. Drug treatments</topic><topic>Tears - analysis</topic><topic>Tears - metabolism</topic><topic>Vitamin A - administration & dosage</topic><topic>Vitamin A - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilbard, Jeffrey P.</creatorcontrib><creatorcontrib>Huang, Andrew J.W.</creatorcontrib><creatorcontrib>Belldegrun, Rebecka</creatorcontrib><creatorcontrib>Lee, Julie S.</creatorcontrib><creatorcontrib>Rossi, Scott R.</creatorcontrib><creatorcontrib>Gray, Kathleen L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilbard, Jeffrey P.</au><au>Huang, Andrew J.W.</au><au>Belldegrun, Rebecka</au><au>Lee, Julie S.</au><au>Rossi, Scott R.</au><au>Gray, Kathleen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>96</volume><issue>2</issue><spage>244</spage><epage>246</epage><pages>244-246</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>The authors evaluated the efficacy of all-trans retinoic acid (vitamin A) ointment as a treatment for keratoconjunctivitis sicca (KCS) in a group of 11 patients selected on the basis of clinical history, slit-lamp examination results, rose Bengal staining, and tear film osmolarity. In this open-label crossover study, vitamin A ointment was no more effective than placebo in increasing tear secretion, as indicated by Schirmer test with proparacaine or tear film osmolarity, or in decreasing ocular surface disease, as indicated by rose Bengal staining. Seven patients stated some pReference for the placebo ointment, two patients for the vitamin A ointment, and two patients had no pReference.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2704543</pmid><doi>10.1016/S0161-6420(89)32909-5</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-6420 |
| ispartof | Ophthalmology (Rochester, Minn.), 1989-02, Vol.96 (2), p.244-246 |
| issn | 0161-6420 1549-4713 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78912085 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Biological and medical sciences Eye Female Humans Keratoconjunctivitis - drug therapy Keratoconjunctivitis Sicca - drug therapy Medical sciences Middle Aged Ointments Osmolar Concentration Pharmacology. Drug treatments Tears - analysis Tears - metabolism Vitamin A - administration & dosage Vitamin A - therapeutic use |
| title | Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A47%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Open-label%20Crossover%20Study%20of%20Vitamin%20A%20Ointment%20as%20a%20Treatment%20for%20Keratoconjunctivitis%20Sicca&rft.jtitle=Ophthalmology%20(Rochester,%20Minn.)&rft.au=Gilbard,%20Jeffrey%20P.&rft.date=1989-02-01&rft.volume=96&rft.issue=2&rft.spage=244&rft.epage=246&rft.pages=244-246&rft.issn=0161-6420&rft.eissn=1549-4713&rft.coden=OPHTDG&rft_id=info:doi/10.1016/S0161-6420(89)32909-5&rft_dat=%3Cproquest_cross%3E78912085%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78912085&rft_id=info:pmid/2704543&rft_els_id=S0161642089329095&rfr_iscdi=true |