Essential roles of the Fas ligand in the development of hepatitis

The Fas ligand (FasL) is expressed in activated T cells and induces apoptosis in Fas-bearing cells. A cytotoxic T lymphocyte (CTL) clone specific for hepatitis B surface antigen (HBsAg) causes an acute liver disease in HBsAg transgenic mice. Here we observed that the CTL clone killed hepatocytes exp...

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Veröffentlicht in:	Nature medicine 1997-04, Vol.3 (4), p.409-413
Hauptverfasser:	Kondo, Toru, Suda, Takashi, Fukuyama, Hidehiro, Adachi, Masashi, Nagata, Shigekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research Cytotoxicity, Immunologic Endotoxins - pharmacology Fas Ligand Protein fas Receptor - metabolism fas Receptor - pharmacology Hepatic Encephalopathy - etiology Hepatic Encephalopathy - immunology Hepatic Encephalopathy - mortality Hepatic Encephalopathy - prevention & control Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Infectious Diseases Membrane Glycoproteins - metabolism Metabolic Diseases Mice Mice, Transgenic Molecular Medicine Neurosciences Solubility Survival Analysis T-Lymphocytes, Cytotoxic
Online-Zugang:	Volltext
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