The Immunomodulator AS-101 Inhibits IL-10 Release and Augments TNFα and IL-1α Release by Mouse and Human Mononuclear Phagocytes

AS-101 is a tellurium-based compound with known immunomodulating properties. The ability of AS-101 to potentiate the effects of chemotherapeutic drugs and augment cytokine productionin vivohas led to clinical trials on AS-101 which are currently being carried out in cancer patients. In the present s...

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Veröffentlicht in:	Cellular immunology 1997-03, Vol.176 (2), p.180-185
Hauptverfasser:	Strassmann, Gideon, Kambayashi, Taku, Jacob, Chaim O., Sredni, Devora
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Cells, Cultured Ethylenes - pharmacology HLA-DR Antigens - biosynthesis Humans Interferon-gamma - pharmacology Interleukin-1 - metabolism Interleukin-10 - antagonists & inhibitors Interleukin-10 - genetics Interleukin-10 - metabolism Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred C57BL Monocytes - drug effects Monocytes - metabolism RNA, Messenger - biosynthesis Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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