Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor

The effect of the drug SR 48692 on the Ca 2+-activated Cl − current induced by neurotensin on Xenopus oocytes injected with cRNAs encoding rodent high and low affinity neurotensin receptors, was examined. In this receptor expression system, SR 48692 failed to antagonize electrophysiological measurem...

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Veröffentlicht in:	Neuroscience letters 1997-02, Vol.223 (3), p.193-196
Hauptverfasser:	Botto, Jean-Marie, Guillemare, Eric, Vincent, Jean-Pierre, Mazella, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - physiology Central nervous system Chlorides - physiology Electric Conductivity Electrophysiology Female Fundamental and applied biological sciences. Psychology Levocabastine Mice Neurotensin Neurotensin - antagonists & inhibitors Neurotensin - pharmacology Oocytes - drug effects Oocytes - physiology Piperidines - pharmacology Pyrazoles - pharmacology Quinolines - pharmacology Rats Receptor Receptors, Neurotensin - agonists Receptors, Neurotensin - antagonists & inhibitors Receptors, Neurotensin - drug effects SR 48692 Vertebrates: nervous system and sense organs Xenopus oocytes
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