Small-Cell Carcinoma of the Endometrium: An Immunohistochemical and Ultrastructural Analysis
Small‐cell carcinoma of the endometrium is a rare neoplasm, and its aggressive behavior has been reported. We report a case of small‐cell carcinoma occurring primarily in the endometrium of a 62‐year‐old woman with postmenopausal vaginal bleeding and lower abdominal pain. The excised uterus showed a...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 1997-02, Vol.23 (1), p.9-16 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Tsujioka, Hiroshi Eguchi, F. Emoto, M. Hachisuga, T. Kawarabayashi, T. Shirakawa, K. |
| description | Small‐cell carcinoma of the endometrium is a rare neoplasm, and its aggressive behavior has been reported. We report a case of small‐cell carcinoma occurring primarily in the endometrium of a 62‐year‐old woman with postmenopausal vaginal bleeding and lower abdominal pain. The excised uterus showed a necrotic polypoid mass and histologically displayed an endometrial small‐cell carcinoma. Immuno‐histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron‐specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain. Ultrastructural analysis revealed the presence of dense core granules in the cytoplasm of tumor cells. The patient died 2 months after surgery because of aggressive behavior of the tumor. We wish to distinguish small‐cell carcinoma of the endometrium from conventional epithelial tumors of the endometrium, because of the former's distinctive histopathologic, immunohistochemical, and ultrastructural characteristics. |
| doi_str_mv | 10.1111/j.1447-0756.1997.tb00798.x |
| format | Article |
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We report a case of small‐cell carcinoma occurring primarily in the endometrium of a 62‐year‐old woman with postmenopausal vaginal bleeding and lower abdominal pain. The excised uterus showed a necrotic polypoid mass and histologically displayed an endometrial small‐cell carcinoma. Immuno‐histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron‐specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain. Ultrastructural analysis revealed the presence of dense core granules in the cytoplasm of tumor cells. The patient died 2 months after surgery because of aggressive behavior of the tumor. 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We report a case of small‐cell carcinoma occurring primarily in the endometrium of a 62‐year‐old woman with postmenopausal vaginal bleeding and lower abdominal pain. The excised uterus showed a necrotic polypoid mass and histologically displayed an endometrial small‐cell carcinoma. Immuno‐histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron‐specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain. Ultrastructural analysis revealed the presence of dense core granules in the cytoplasm of tumor cells. The patient died 2 months after surgery because of aggressive behavior of the tumor. We wish to distinguish small‐cell carcinoma of the endometrium from conventional epithelial tumors of the endometrium, because of the former's distinctive histopathologic, immunohistochemical, and ultrastructural characteristics.</description><subject>Carcinoma, Small Cell - chemistry</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Carcinoma, Small Cell - ultrastructure</subject><subject>Chromogranin A</subject><subject>Chromogranins - analysis</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>electron microscopy</subject><subject>endometrial cancer</subject><subject>Endometrial Neoplasms - chemistry</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - ultrastructure</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratins - analysis</subject><subject>Magnetic Resonance Imaging</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Mucin-1 - analysis</subject><subject>Phosphopyruvate Hydratase - analysis</subject><subject>small-cell carcinoma</subject><subject>Tomography, X-Ray Computed</subject><subject>Urography</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFO4zAQhi0EAra7j4AUceCW4ImT2OaAVGW7BVTBYUG9rGS5jqOm2AnYibZ9exy16h1fPPI_81nzIXQNOIFwbjcJZBmNMc2LBDinSb_CmHKWbE_Q5TE6DTXJIGaYFhfoh_cbjIFyYOfonGOeMYBL9O-vlcbEpTYmKqVTTdtZGXV11K91NGurzureNYO9i6Zt9Gjt0HbrxvedWmvbKGki2VbRm-md9L0bVD-48DZtpdn5xv9EZ7U0Xv863BP09mf2Wj7Ei5f5YzldxCoDymKaqjSvaZ5KvGKAARShvM6gyIEohRkrVhUmddiDEKIlqFyxSjImdaXTqijIBN3suR-u-xy074VtvAoryVZ3gxeUccAkHRvv9o3Kdd47XYsP11jpdgKwGNWKjRj9idGfGNWKg1qxDcNXh1-GldXVcfTgMuT3-_x_Y_TuG2Tx9DIPRQDEe0AQrLdHgHTvoqCE5mL5PBdP5ZK_LtO5-E2-AGfjmOI</recordid><startdate>199702</startdate><enddate>199702</enddate><creator>Tsujioka, Hiroshi</creator><creator>Eguchi, F.</creator><creator>Emoto, M.</creator><creator>Hachisuga, T.</creator><creator>Kawarabayashi, T.</creator><creator>Shirakawa, K.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199702</creationdate><title>Small-Cell Carcinoma of the Endometrium: An Immunohistochemical and Ultrastructural Analysis</title><author>Tsujioka, Hiroshi ; Eguchi, F. ; Emoto, M. ; Hachisuga, T. ; Kawarabayashi, T. ; Shirakawa, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4178-72c25f752a0b81011c379f416513cc0886bd03f807333ea1c5c8da88aede2d663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Carcinoma, Small Cell - chemistry</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Carcinoma, Small Cell - ultrastructure</topic><topic>Chromogranin A</topic><topic>Chromogranins - analysis</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>electron microscopy</topic><topic>endometrial cancer</topic><topic>Endometrial Neoplasms - chemistry</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - ultrastructure</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratins - analysis</topic><topic>Magnetic Resonance Imaging</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Mucin-1 - analysis</topic><topic>Phosphopyruvate Hydratase - analysis</topic><topic>small-cell carcinoma</topic><topic>Tomography, X-Ray Computed</topic><topic>Urography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsujioka, Hiroshi</creatorcontrib><creatorcontrib>Eguchi, F.</creatorcontrib><creatorcontrib>Emoto, M.</creatorcontrib><creatorcontrib>Hachisuga, T.</creatorcontrib><creatorcontrib>Kawarabayashi, T.</creatorcontrib><creatorcontrib>Shirakawa, K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsujioka, Hiroshi</au><au>Eguchi, F.</au><au>Emoto, M.</au><au>Hachisuga, T.</au><au>Kawarabayashi, T.</au><au>Shirakawa, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-Cell Carcinoma of the Endometrium: An Immunohistochemical and Ultrastructural Analysis</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>1997-02</date><risdate>1997</risdate><volume>23</volume><issue>1</issue><spage>9</spage><epage>16</epage><pages>9-16</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Small‐cell carcinoma of the endometrium is a rare neoplasm, and its aggressive behavior has been reported. We report a case of small‐cell carcinoma occurring primarily in the endometrium of a 62‐year‐old woman with postmenopausal vaginal bleeding and lower abdominal pain. The excised uterus showed a necrotic polypoid mass and histologically displayed an endometrial small‐cell carcinoma. Immuno‐histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron‐specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain. Ultrastructural analysis revealed the presence of dense core granules in the cytoplasm of tumor cells. The patient died 2 months after surgery because of aggressive behavior of the tumor. We wish to distinguish small‐cell carcinoma of the endometrium from conventional epithelial tumors of the endometrium, because of the former's distinctive histopathologic, immunohistochemical, and ultrastructural characteristics.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9094811</pmid><doi>10.1111/j.1447-0756.1997.tb00798.x</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Carcinoma, Small Cell - chemistry Carcinoma, Small Cell - pathology Carcinoma, Small Cell - ultrastructure Chromogranin A Chromogranins - analysis Cytoplasmic Granules - ultrastructure electron microscopy endometrial cancer Endometrial Neoplasms - chemistry Endometrial Neoplasms - pathology Endometrial Neoplasms - ultrastructure Female Humans Immunohistochemistry Keratins - analysis Magnetic Resonance Imaging Microscopy, Electron Middle Aged Mucin-1 - analysis Phosphopyruvate Hydratase - analysis small-cell carcinoma Tomography, X-Ray Computed Urography |
| title | Small-Cell Carcinoma of the Endometrium: An Immunohistochemical and Ultrastructural Analysis |
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