Role of Nd3+ and Pb2+ on the RNA Cleavage Reaction by a Small Ribozyme

Leadzyme is a ribozyme that requires Pb2+. We have previously shown that the addition of Nd3+ in the presence of Pb2+ increased significantly the yield of the RNA cleavage reaction by a leadzyme, although other rare earth ions or divalent ions except Pb2+ did not promote the reaction [Sugimoto, N.,...

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Veröffentlicht in:	Biochemistry (Easton) 1997-03, Vol.36 (12), p.3514-3521
Hauptverfasser:	Ohmichi, Tatsuo, Sugimoto, Naoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Electrophoresis, Polyacrylamide Gel Hot Temperature Lead - metabolism Metals - metabolism Models, Chemical Neodymium - metabolism Nucleic Acid Conformation Ribonuclease, Pancreatic - metabolism RNA - metabolism RNA, Catalytic - metabolism Spectrophotometry, Ultraviolet
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