Insulin-like growth factor-II (IGF-II) inhibits both the cellular uptake of β-galactosidase and the binding of β-galactosidase to purified IGF-II/mannose 6-phosphate receptor

The insulin-like growth factor-II/mannose 6-phosphate receptor which targets acid hydrolases to lysosomes, has two different binding sites, one for the mannose 6-phosphate (Man-6-P) recognition marker on lysosomal enzymes and the other for insulin-like growth factor-II (IGF-II). We have asked whethe...

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Veröffentlicht in:	The Journal of biological chemistry 1989-03, Vol.264 (8), p.4710-4714
Hauptverfasser:	Kiess, W, Thomas, C L, Greenstein, L A, Lee, L, Sklar, M M, Rechler, M M, Sahagian, G G, Nissley, S P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta -galactosidase beta-Galactosidase - isolation & purification beta-Galactosidase - metabolism Biological and medical sciences Biological Transport Cell Line Cell receptors Cell structures and functions Chromatography, Affinity Female Fundamental and applied biological sciences. Psychology Galactosidases - metabolism Immunosorbent Techniques insulin-like growth factor II Insulin-Like Growth Factor II - pharmacology Liver - metabolism lysosomes Molecular and cellular biology Neuroglia - metabolism Placenta - analysis Pregnancy Rats Receptor, IGF Type 2 Receptors, Cell Surface - metabolism Receptors, Somatomedin Somatomedins - pharmacology
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